Patent US4645660A successfully refreshed from Google Patents.
US4645660A
Expired / Lapsed
US
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Increasing labeling efficiency by forming diagnostic agent in the presence of ascorbic acid or the like
Assignee: Nihon Medi Physics Co Ltd
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Filing: 1984-04-26
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Granted: 1987-02-24
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Expires: 2004-04-26
Abstract
Abstract A radioactive diagnostic agent having high labeling efficiency, prepared by bringing an aqueous solution of a radioactive metallic element contaminated with a non-radioactive metallic ions into contact with a non-radioactive carrier comprising a carrier substance having a chelate-forming property and optionally a physiologically active substance chemically bonded thereto, at least one of said aqueous solution and said non-radioactive carrier comprising at least one reductive material chosen from ascorbic acid and erythrobic acid, and their salts and esters.
Inventors
- 👤 Keietsu Takahashi
- 👤 Nobuo Ueda
- 👤 Masaaki Hazue
- 👤 Akira Yokoyama
- 👤 Yoshiro Ohmomo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:59
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/088; A61K51/081; A61K51/12; A61K51/121; A61K2123/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
85 words
A method for enhancing the labeling efficiency of a non-radioactive carrier with a radioactive metallic element other than technetium-99m in the presence of a non-radioactive metallic element as an impurity, said non-radioactive carrier comprising deferoxamine or its combined product with a physiologically active substance, said method comprising the step of contacting the non-radioactive carrier with the radioactive metallic element in the presence of a non-toxic amount of a reductive material selected from the group consisting of ascorbic acid, erythorbic acid, and their salts and esters.
Claim 2
Independent Claim
85 words
A method for enhancing the labeling efficiency of a non-radioactive carrier with a radioactive metallic element other than technetium-99m in the presence of a non-radioactive metallic element as an impurity, said non-radioactive carrier comprising deferoxamine or its combined product with a physiologically active substance, said method comprising the step of contacting the non-radioactive carrier with the radioactive metallic element in the presence of a non-toxic amount of a reductive material selected from the group consisting of ascorbic acid, erythorbic acid, and their salts and esters.
Claim 3
Dependent Claim
20 words
A method as recited in claim 1 wherein the non-radioactive carrier comprises deferoxamine chemically combined with a physiologically active substance.
Claim 4
Dependent Claim
14 words
A method as recited in claim 2 wherein the physiologically active substance is fibrinogen.
Claim 5
Dependent Claim
48 words
A method as recited in claim 3 wherein the non-radioactive carrier is brought into contact with an aqueous solution comprising the radioactive metallic element with non-radioactive metallic ions as impurity, at least one of said non-radioactive carrier or said aqueous solution being in combination with said reductive material.
Claim 6
Dependent Claim
48 words
A method as recited in claim 2 wherein the non-radioactive carrier is brought into contact with an aqueous solution comprising the radioactive metallic element with non-radioactive metallic ions as impurity, at least one of said non-radioactive carrier or said aqueous solution being in combination with said reductive material.
Claim 7
Dependent Claim
33 words
A method as recited in claim 5 wherein said non-radioactive carrier is in combination with said reductive material when said carrier is brought into contact with said aqueous solution comprising radioactive metallic element.
Claim 8
Dependent Claim
35 words
A method as recited in claim 6 wherein the amount of reductive material is sufficient to reduce the contaminating non-radioactive metallic ions so as to assure a high radioactivity as well as high labeling efficiency.
Claim 9
Dependent Claim
26 words
A method as recited in claim 1 wherein the radioactive metallic element is selected from the group consisting of gallium-67, gallium-68, indium-111, indium-113m, thallium-201, and cobalt-55.
References Cited (Backward Citations)
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US4489053A
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US4455291A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-23 | 1990-08-25 | 1991-02-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-23 | 1994-08-25 | 1995-02-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-23 | 1998-08-25 | 1999-02-24 | $7700.00 | Window Closed / Lapsed |