Patent US4642340A successfully refreshed from Google Patents.
US4642340A
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Stable compounds of glucosamine sulphate
Assignee: Rottapharm SpA
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Filing: 1982-04-30
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Granted: 1987-02-10
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Expires: 2002-04-30
Abstract
Abstract The compound consists of a mixed salt of glucosamine sulphate and sodium chloride corresponding to the formula: ##STR1## and is in the form of a crystalline powder with a melting point above 300° C. The salt is stable at ambient temperatures and humidities and has pharmacological properties practically identical to those of glucosamine sulphate.
Inventors
- 👤 Paolo Senin
- 👤 Francesco Makovec
- 👤 Luigi Rovati
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 15:50
CPC Classifications
C; C07; C07H; C07H5/00; C07H5/04; C07H5/06; A; A61; A61P; A61P29/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
31 words
Mixed salt of glucosamine sulphate and sodium chloride corresponding to the formula: ##STR3## said mixed salt being in the form of a crystalline powder having a melting point above 300° C.
Claim 2
Dependent Claim
31 words
Mixed salt of glucosamine sulphate and sodium chloride corresponding to the formula: ##STR3## said mixed salt being in the form of a crystalline powder having a melting point above 300° C.
Claim 3
Dependent Claim
145 words
Process for the preparation of the mixed salt of glucosamine sulphate and sodium chloride according to claim 1, characterised by the steps of: (a) dissolving dry sodium chloride in 5.5 to 7.5 parts by weight of distilled water for every part of sodium chloride at a temperature of from 50° to 70° C. under agitation; (b) dissolving in the solution obtained in step (a) the stoichiometric quantity of glucosamine sulphate at a temperature of from 35° to 45° C., under agitation; (c) precipitating the mixed salt by the addition of a liquid precipitant which is miscible with water and in which the said mixed salt has a solubility not greater than 0.1% (w/v) while operating under agitation at a temperature of from 40° C. to 50° C.; (d) completing the precipitation by lowering the temperature of the mixture; and (e) recovering the precipitated mixed salt.
Claim 4
Dependent Claim
16 words
The process of claim 2, wherein the liquid precipitant is acetone, ethanol, acetonitrile, tetrahydrofuran or dioxan.
Claim 5
Dependent Claim
41 words
The process of claim 2 or 3, wherein the liquid precipitant is added in a proportion of 5 to 7 parts by volume with respect to the water used in step (a) over a period of from 2.5 to 3.5 hours.
Claim 6
Dependent Claim
20 words
The process of claim 2 or 3, wherein the recovered mixed salt is dried in air-circulation oven at 45°-65° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-09 | 1990-08-11 | 1991-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-09 | 1994-08-11 | 1995-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-09 | 1998-08-11 | 1999-02-10 | $7700.00 | Window Closed / Lapsed |