Patent US4642242A successfully refreshed from Google Patents.
US4642242A
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US
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Permanently bonded antithrombogenic polyurethane surface
Assignee: Becton Dickinson and Co
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Filing: 1986-03-19
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Granted: 1987-02-10
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Expires: 2006-03-19
Abstract
Abstract An antithrombogenic polyurethane polymer being bound to a support substrate wherein the antithrombogenic agent is reacted through an aldehyde group with an amine functionality of a polyurethane-urea to form the covalently bonded antithrombogenic material.
Inventors
- 👤 Donald D. Solomon
- 👤 Charles W. McGary
- 👤 Vincent J. Pascarella
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:59
CPC Classifications
C; C08; C08G; C08G18/00; C08G18/06; C08G18/83; C08G18/84; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0023; A61L33/0029; C08G18/08; C08G18/0804; C08G18/0809; C08G18/0814
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
103 words
A process for imparting antithrombogenic activity to polyurethane polymer materials, which comprises: a. treating the surface of a solid support with a solution of a protonated amine rich polyurethane-urea so that the polyurethane-urea is bonded to the support substrate; b. removing solvent from the treated substrate to form a layer of the polyurethane-urea upon the support substrate; c. activating the amine functionality on the polyurethane-urea with an alkaline buffer to form free amine groups; and d. reacting the free amine groups with an aldehyde containing antithrombogenic agent to covalently bond the antithrombogenic agent to the polyurethane-urea in the presence of a reducing agent.
Claim 2
Dependent Claim
103 words
A process for imparting antithrombogenic activity to polyurethane polymer materials, which comprises: a. treating the surface of a solid support with a solution of a protonated amine rich polyurethane-urea so that the polyurethane-urea is bonded to the support substrate; b. removing solvent from the treated substrate to form a layer of the polyurethane-urea upon the support substrate; c. activating the amine functionality on the polyurethane-urea with an alkaline buffer to form free amine groups; and d. reacting the free amine groups with an aldehyde containing antithrombogenic agent to covalently bond the antithrombogenic agent to the polyurethane-urea in the presence of a reducing agent.
Claim 3
Dependent Claim
20 words
The process of claim 1 wherein the protonated amine rich polyurethane-urea is prepared from a polyurethane prepolymer and a diamine.
Claim 4
Dependent Claim
24 words
The process of claim 2 wherein the mole ratio of diamine to free isocyanate groups in the prepolymer is from about 0.6:1 to 1:1.
Claim 5
Dependent Claim
24 words
The process of claim 1 wherein the antithrombogenic agent is heparin which is reacted with an aldehyde inducing compound to form aldehyde modified heparin.
Claim 6
Dependent Claim
22 words
The process of claim 1 wherein the aldehyde inducing compound is selected from the group consisting of sodium periodate and nitrous acid.
Claim 7
Dependent Claim
16 words
The process of claim 1 wherein the alkaline buffer has a pH greater than about 8.0.
Claim 8
Dependent Claim
19 words
The process of claim 1 wherein the polyurethane polymer is selected from thermosetting polyurethane polymer and thermoplastic polyurethane polymers.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-09 | 1990-08-11 | 1991-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-09 | 1994-08-11 | 1995-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-09 | 1998-08-11 | 1999-02-10 | $7700.00 | Window Closed / Lapsed |