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US4640931A
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3-(indian-5-yloxy (or thio)) cyclopentanecarboxylic acid analogues
Assignee: Ono Pharmaceutical Co Ltd
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Filing: 1985-10-29
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Granted: 1987-02-03
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Expires: 2005-10-29
Abstract
Abstract The present invention relates to novel compounds of the general formula: <IMAGE> (I) wherein X represent an oxygen atom or a sulfur atom and R represents a hydrogen atom or an alkyl group of 1-4 carbon atoms, and non-toxic salts thereof when R represents a hydrogen atom, possessing an inhibitory effect on cerebral edema.
Inventors
- 👤 Katsuhiro Imaki
- 👤 Tadao Okegawa
- 👤 Yoshinobu Arai
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 09:15
CPC Classifications
C; C07; C07C; C07C323/00; A; A61; A61P; A61P7/00; A61P7/10; C07C309/00; C07C327/00; C07C62/00; C07C62/18; C07C62/26
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
46 words
A 3-(indan-5-yloxy (or thio))cyclopentanecarboxylic acid analogue of the general formula: ##STR21## wherein X represents an oxygen atom or a sulfur atom and R represents a hydrogen atom or an alkyl group of 1-4 carbon atoms; or a non-toxic salt thereof when R represents a hydrogen atom.
Claim 2
Dependent Claim
46 words
A 3-(indan-5-yloxy (or thio))cyclopentanecarboxylic acid analogue of the general formula: ##STR21## wherein X represents an oxygen atom or a sulfur atom and R represents a hydrogen atom or an alkyl group of 1-4 carbon atoms; or a non-toxic salt thereof when R represents a hydrogen atom.
Claim 3
Dependent Claim
12 words
An analogue according to claim 1, wherein X represents an oxygen atom.
Claim 4
Dependent Claim
12 words
An analogue according to claim 1, wherein X represents a sulfur atom.
Claim 5
Dependent Claim
16 words
An analogue according to claim 1, wherein R represents an alkyl group of 1-4 carbon atoms.
Claim 6
Dependent Claim
12 words
An analogue according to claim 1, wherein R represents a hydrogen atom.
Claim 7
Dependent Claim
36 words
An analogue according to claim 1, which is 1,3-trans-3-[((2RS)-2-cyclopentyl-2-methyl-6,7-dichloro-1-oxoindan-5-yl)oxy]cyclopentanecarboxylic acid or its methyl ester, (1S, 3S)-3-[((2RS)-2-cyclopentyl-2-methyl-6,7-dichloro-1-oxoindan-5-yl)oxy]cyclopentanecarboxylic acid or its methyl ester, (1S, 3S)-3-[((2RS)-2-cyclopentyl-2-methyl-6,7-dichloro-1-oxoindan-5-yl)thio]cyclopentanecarboxylic acid or its methyl ester, or (1S, 3S)-3-[((2S)-2-cyclopentyl-2-methyl-6,7-dichloro-1-oxoindan-5-yl)oxy]cyclopentanecarboxylic acid or its methyl ester.
Claim 8
Dependent Claim
63 words
A composition for treating cerebral edema which comprises an effective amount of a 3-(indan-5-yloxy (or thio)cyclopentanecarboxylic acid analogue of the general formula: ##STR22## wherein X represents an oxygen atom or a sulfur atom and R represents a hydrogen atom or an alkyl group of 1-4 carbon atoms; or a non-toxic salt thereof when R represents a hydrogen atom and a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
63 words
A composition for treating cerebral edema which comprises an effective amount of a 3-(indan-5-yloxy (or thio)cyclopentanecarboxylic acid analogue of the general formula: ##STR22## wherein X represents an oxygen atom or a sulfur atom and R represents a hydrogen atom or an alkyl group of 1-4 carbon atoms; or a non-toxic salt thereof when R represents a hydrogen atom and a pharmaceutically acceptable carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-02 | 1990-08-04 | 1991-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-02 | 1994-08-04 | 1995-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-02 | 1998-08-04 | 1999-02-03 | $7700.00 | Window Closed / Lapsed |