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US4640833A
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Use of perfluorobromoalkyl ethers as X-ray contrast agents
Assignee: Childrens Hospital Research Foundation
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Filing: 1985-03-11
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Granted: 1987-02-03
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Expires: 2005-03-11
Abstract
Abstract Method of X-raying animals using as a contrast agent a perfluorobromoalkyl ether of the formula CmF2m+1OCnF2nBr where m and n independently are integers of from 2 to 6, wherein the ether is used either neat or in an aqueous dispersion such as an emulsion.
Inventors
- 👤 Christ Tamborski
- 👤 Leland C. Clark, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:51
CPC Classifications
C; C07; C07C; C07C43/00; C07C43/02; C07C43/03; C07C43/04; C07C43/12; C07C43/123; A; A61; A61K; A61K49/00; A61K49/04
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
63 words
In a method of radioimaging an internal region of an animal wherein a radiopaque agent is introduced into the region and the region is X-rayed while perfused with the radiopaque agent, the improvement which comprises employing as the radiopaque agent a perfluorobromoalkyl ether of the formula: C.sub.m F.sub.2m+1 OC.sub.n F.sub.2n Br where m and n independently are integers of from 2 to 6.
Claim 2
Dependent Claim
63 words
In a method of radioimaging an internal region of an animal wherein a radiopaque agent is introduced into the region and the region is X-rayed while perfused with the radiopaque agent, the improvement which comprises employing as the radiopaque agent a perfluorobromoalkyl ether of the formula: C.sub.m F.sub.2m+1 OC.sub.n F.sub.2n Br where m and n independently are integers of from 2 to 6.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein the ether is F-1-bromobutylisopropyl ether.
Claim 4
Dependent Claim
16 words
The method of claim 1 wherein the radiopaque agent comprises an aqueous dispersion of the ether.
Claim 5
Dependent Claim
36 words
The method of claim 3 wherein the aqueous dispersion contains about 50-90% by volume of water, about 0.5-10% by weight of a dispersant based on the water content, and about 5-20% by volume of the ether.
Claim 6
Dependent Claim
13 words
The method of claim 1 wherein the agent is introduced into a lung.
Claim 7
Dependent Claim
10 words
The method of claim 5 wherein the agent is F-1-bromobutylisopropylether.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-02 | 1990-08-04 | 1991-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-02 | 1994-08-04 | 1995-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-02 | 1998-08-04 | 1999-02-03 | $7700.00 | Window Closed / Lapsed |