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US4639424A
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Determination of alkali metals
Assignee: Abbott Laboratories
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Filing: 1984-07-27
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Granted: 1987-01-27
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Expires: 2004-07-27
Abstract
Abstract A method for determining the alkali metal content of a liquid such as protein-containing liquids wherein a liquid containing alkali metal cation is contacted with a monocyclic crown ether capable of forming a complex with the alkali metal cation in a substantially inert solvent and an anionic dye, is disclosed. The alkali metal forms a complex with the ether and the dye in the solvent, the presence of which is a measure of the alkali metal content of the liquid.
Inventors
- 👤 Sie-Ting Wong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 18:28
CPC Classifications
G; G01; G01N; G01N21/00; G01N33/00; G01N33/48; G01N33/50; G01N33/84; G01N31/00; G01N31/22; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
145 words
A method for determining the alkali metal content of a protein-containing liquid which has not been treated to remove proteins, which method comprises the steps of: (a) contacting the protein-containing liquid containing an alkali metal cation with (1) a monocyclic crown ether capable of forming a complex with the alkali metal cation, (2) a solvent selected from the group consisting of diphenyl ether, p-chlorobenzotrifluoride, 3,4-dichlorobenzotrifluoride, 1,2,4-trichlorobenzene, trichlorotrifluoroethane and mixtures thereof, and (3) an anionic dye to form a reaction mixture having an aqueous phase and a phase containing said solvent; (b) separating from the mixture of step (a) the solvent phase, said phase containing said solvent containing a complex of the alkali metal cation, the crown ether and the anionic dye; and (c) determining the concentration of the dye in the solvent phase as a measure of the alkali metal content of the protein-containing liquid.
Claim 2
Independent Claim
145 words
A method for determining the alkali metal content of a protein-containing liquid which has not been treated to remove proteins, which method comprises the steps of: (a) contacting the protein-containing liquid containing an alkali metal cation with (1) a monocyclic crown ether capable of forming a complex with the alkali metal cation, (2) a solvent selected from the group consisting of diphenyl ether, p-chlorobenzotrifluoride, 3,4-dichlorobenzotrifluoride, 1,2,4-trichlorobenzene, trichlorotrifluoroethane and mixtures thereof, and (3) an anionic dye to form a reaction mixture having an aqueous phase and a phase containing said solvent; (b) separating from the mixture of step (a) the solvent phase, said phase containing said solvent containing a complex of the alkali metal cation, the crown ether and the anionic dye; and (c) determining the concentration of the dye in the solvent phase as a measure of the alkali metal content of the protein-containing liquid.
Claim 3
Dependent Claim
15 words
A method as defined in claim 1, wherein the protein-containing liquid is a blood serum.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-01-26 | 1990-07-28 | 1991-01-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-01-26 | 1994-07-28 | 1995-01-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-01-26 | 1998-07-28 | 1999-01-27 | $7700.00 | Window Closed / Lapsed |