6-(acylaminoaryl)-3(2H)-pyridazinone derivatives and their use

Claim 1

A 6-(alkanoylaminoaryl)-3(2H)-pyridazinone derivative of the formula I ##STR558## wherein the substituents on the phenylene radical are para to one another, A and B are each hydrogen or together form a bond, R 1 is hydrogen or methyl, R 2 is hydrogen or, where A and B are each hydrogen R 1 and R 2 together form a C 1 -C 2 -alkylene radical, R 3 is a straight-chain C 1 -C 4 -alkylene group which can be substituted by C 1 -C 3 -alkyl group or by two methyl groups, and R 4 is (b) a group of the formula II ##STR559## where the broken line can be an additional bond, R 5 is C 1 -C 4 -alkyl which is unsubstituted or substituted by phenyl, or phenyl which is unsubstituted or substituted by 1 or 2 halogen atoms, or is a group of the formula R 7 R 8 N, where R 7 is hydrogen or phenyl, and R 8 is C 1 -C 4 -acyl or benzoyl, or R 7 and R 8 , together with the nitrogen atom, form a benzimidazol-2-on-1-yl group, R 6 is C 1 -C 4 -alkyl, hydroxyl, C 1 -C 4 -acyl, (C 1 -C 5 -alkoxy)-carbonyl or cyano, or R 5 and R 6 together form a C 1 -C 4 -alkylene chain, and m is 0, 1 or 2, or (c) a group of the formula III ##STR560## `where R 9 is a C 1 -C 3 -hydrocarbon radical which may be substituted by phenyl or a C 3 -C 8 -cycloalkyl (in which case a C 5 -C 8 -cycloalkyl group can be benzofused) or C 6 -C 10 -aryl which can contain 1 to 3 C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, trifluoromethyl, nitro, hydroxyl, C 1 -C 4 -acyl, carboxyl, (C 1 -C 5 -alkoxy)-carbonyl, amido, N-(C 1 -C 4 -alkyl)amido, N,N-di-(C 1 -C 4 -alkyl)amido, tri(C 1 -C 4 -alkyl)-silyl, cyano, amino, C 1 -C 4 -alkylamino, di-(C 1 -C 4 -alkyl)amino, C 1 -C 4 -alkanoyl amino groups and/or halogen atoms; a C 6 -C 10 -aroyl group which is unsubstituted or substituted by 1 to 3 C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, trifluoromethyl, nitro, hydroxyl, C 1 -C 4 -alkanoyl, carboxyl, C 1 -C 5 -alkoxy-carbonyl, N,N-di-(C 1 -C 4 -alkyl)-amido, cyano, di-(C 1 -C 4 -alkyl)-amino groups and/or halogen atoms; or a hetaroyl group having 5 to 6 ring members, which can contain 1 to 3 hetero atoms and may be benzofused; a C 3 -C 12 -cycloalkyl, C 1 -C 8 -acyl or (C 1 -C 5 -alkoxy)-carbonyl group or a C 6 -C 10 -aryl radical which is unsubstituted or monosubstituted, disubstituted or trisubstituted by halogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, hydroxyl, trifluoromethyl, C 1 -C 4 -acyl, carboxyl, (C 1 -C 5 -alkoxy)-carbonyl, cyano, nitro, amino, C 1 -C 4 -alkylamino, di-C 1 -C 4 -alkylamino, arylamino or C 1 -C 4 -acylamino; or a 5-membered or 6-membered hetaryl radical which may be benzofused, contains 1 to 3 nitrogen atoms and may or may not contain an oxygen atom or sulfur atom, and p is 2 or 3, or (e) a group of the formula V ##STR561## where R 12 and R 13 are each hydrogen, halogen, C 1 -C 4 -alkyl or C 1 -C 4 -alkoxy, and n is 1, 2, or 3.