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Patent US4634720A successfully refreshed from Google Patents.
US4634720A
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Process for the preparation of hard tissue prosthetics
Assignee: Dow Chemical Co
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Filing: 1985-02-19
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Granted: 1987-01-06
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Expires: 2005-02-19
Abstract
Abstract An in situ polymerization process is disclosed whereby an α-amino acid N-carboxyanhydride is blended intimately and efficiently with one or more calcium phosphate biomaterials. The polymerization proceeds at ambient temperature and pressure without the need for initiators or surface modification of the calcium phosphate biomaterials. The resulting composite material may subsequently be ground and blended with a compatible water soluble pore-forming agent and then molded to form dense, shaped objects which may be made porous be leaching out said water soluble pore-forming agent. The resulting shaped objects may then be used as hard tissue prosthetics either alone or in conjunction with conventional prostheses.
Inventors
- 👤 Linneaus C. Dorman
- 👤 Paul A. Meyers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:52
CPC Classifications
C; C08; C08G; C08G69/00; C08G69/02; C08G69/08; C08G69/10; A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46; A61L27/50; A61L27/56; A61F; A61F2210/00; A61F2210/0004
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
88 words
A process for the preparation of a composite material containing from about 25 to about 75 percent by weight of a calcium phosphate biomaterial and about 75 to about 25 percent by weight of an α-amino acid polymer which comprises polymerizing in situ an N-carboxyanhydride of an α-amino acid in the presence of a powdered calcium phosphate biomaterial, said polymerization taking place in an inert organic solvent, said process including the additional step of adding a pore-forming agent to the composite material prepared by said in situ polymerization.
Claim 2
Dependent Claim
88 words
A process for the preparation of a composite material containing from about 25 to about 75 percent by weight of a calcium phosphate biomaterial and about 75 to about 25 percent by weight of an α-amino acid polymer which comprises polymerizing in situ an N-carboxyanhydride of an α-amino acid in the presence of a powdered calcium phosphate biomaterial, said polymerization taking place in an inert organic solvent, said process including the additional step of adding a pore-forming agent to the composite material prepared by said in situ polymerization.
Claim 3
Dependent Claim
89 words
A process for the preparation of a composite material containing from about 40 to about 60 percent by weight of a calcium phosphate biomaterial and from about 60 to about 40 percent by weight of an α-amino acid polymer which comprises polymerizing in situ an N-carboxyanhydride of an α-amino acid in the presence of a powdered calcium phosphate biomaterial, said polymerization taking place in an inert organic solvent, said process including the additional step of adding a pore-forming agent to the composite material prepared by said in situ polymerization.
Claim 4
Dependent Claim
89 words
A process for the preparation of a composite material containing from about 40 to about 60 percent by weight of a calcium phosphate biomaterial and from about 60 to about 40 percent by weight of an α-amino acid polymer which comprises polymerizing in situ an N-carboxyanhydride of an α-amino acid in the presence of a powdered calcium phosphate biomaterial, said polymerization taking place in an inert organic solvent, said process including the additional step of adding a pore-forming agent to the composite material prepared by said in situ polymerization.
Claim 5
Dependent Claim
24 words
The process of claim 1 wherein said N-carboxyanhydride is glutamic acid N-carboxyanhydride and said calcium phosphate biomaterial is hydroxyapatite, tricalcium phosphate, or mixtures thereof.
Claim 6
Dependent Claim
24 words
The process of claim 2 wherein said N-carboxyanhydride is glutamic acid N-carboxyanhydride and said calcium phosphate biomaterial is hydroxyapatite, tricalcium phosphate, or mixtures thereof.
Claim 7
Dependent Claim
14 words
The process of claim 3 wherein said glutamic acid N-carboxyanhydride has a γ-ester residue.
Claim 8
Dependent Claim
14 words
The process of claim 4 wherein said glutamic acid N-carboxyanhydride has a γ-ester residue.
Claim 9
Dependent Claim
18 words
The process of claim 5 wherein said γ-ester residue is a methyl or benzyl ester of glutamic acid.
Claim 10
Dependent Claim
18 words
The process of claim 6 wherein said γ-ester residue is a methyl or benzyl ester of glutamic acid.
Claim 11
Dependent Claim
12 words
The process of claim 1 carried out at ambient temperature and pressure.
Claim 12
Dependent Claim
12 words
The process of claim 2 carried out at ambient temperature and pressure.
Claim 13
Dependent Claim
27 words
The process of claim 1 wherein said pore-forming agent is selected from the group consisting of poly(2-ethyl-2-oxazoline), polyvinyl pyrrolidone, polyvinyl alcohol, methylcellulose, sodium chloride, and potassium chloride.
Claim 14
Dependent Claim
27 words
The process of claim 2 wherein said pore-forming agent is selected from the group consisting of poly(2-ethyl-2-oxazoline), polyvinyl pyrrolidone, polyvinyl alcohol, methylcellulose, sodium chloride, and potassium chloride.
Claim 15
Dependent Claim
14 words
The process of claim 1 wherein said pore-forming agent is poly(2-ethyl-2-oxazoline) or sodium chloride.
Claim 16
Dependent Claim
14 words
The process of claim 2 wherein said pore-forming agent is poly(2-ethyl-2-oxazoline) or sodium chloride.
Claim 17
Dependent Claim
39 words
The process of claim 1 wherein said pore-forming agent is present in an amount of about 5 to about 30 percent by weight, said percent by weight being based upon the total weight of the composite plus poreforming agent.
Claim 18
Dependent Claim
39 words
The process of claim 2 wherein said pore-forming agent is present in an amount of about 5 to about 30 percent by weight, said percent by weight being based upon the total weight of the composite plus poreforming agent.
Claim 19
Dependent Claim
25 words
The process of claim 1 wherein said inert organic solvent is selected from the group consisting of chloroform, dioxane, tetrahydrofuran, methylene chloride, and mixtures thereof.
Claim 20
Dependent Claim
25 words
The process of claim 2 wherein said inert organic solvent is selected from the group consisting of chloroform, dioxane, tetrahydrofuran, methylene chloride, and mixtures thereof.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1990-01-05 | 1990-07-07 | 1991-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-01-05 | 1994-07-07 | 1995-01-06 | $3760.00 | Window Closed / Lapsed |
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