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US4626512A
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Standard solution for simultaneously calibrating a plurality of ion electrodes
Assignee: Horiba Ltd
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Filing: 1985-05-22
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Granted: 1986-12-02
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Expires: 2005-05-22
Abstract
Abstract A standard solution for simultaneously calibrating a plurality of ion electrodes for determining a plurality of ion electrodes for determining a plurality of ions including at least potassium ions and calcium ions in blood, the improvement wherein the concentration of the standard solution for a potassium ion electrode and a calcium ion electrode is adjusted in accordance with the following equations: ##EQU1## As for potassium ion, C=C.sub.o ·10.sup.-ΔE/60 As for calcium ion, C=C.sub.o ·10.sup.-ΔE/30 As for potassium ion, A=-0.130 to -0.065 As for calcium ion, A=-0.240 to -0.172 wherein E: is the potential difference when an ionic strength of 150 mM is used as the standard; μ: is the ionic strength; C o : is the calibrated concentration; C: is the concentration of reagent added; and A: is the correction factor.
Inventors
- 👤 Narihiro Oku
- 👤 Seiji Usui
- 👤 Hiroaki Uematsu
- 👤 Takeshi Kohno
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 17:45
CPC Classifications
G; G01; G01N; G01N27/00; G01N27/26; G01N27/416; G01N27/4163; G01N27/4165; G01N33/00; G01N33/48; G01N33/50; G01N33/84; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/108331
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
135 words
A standard solution for simultaneously calibrating a plurality of ion electrodes for determining a plurality of ions, which includes at least potassium ions and calcium ions in blood, said standard solution consisting essentially of an aqueous solution of sodium chloride, potassium chloride, calcium carbonate, Tris(hydroxy)aminomethane and hydrochloric acid, wherein the concentration of the standard solution for the potassium ion electrode and the calcium ion electrode is adjusted in accordance with the following equations: ##EQU4## potassium ions: C=C.sub.o ·10.sup.-ΔE/60 calcium ions: C=C.sub.o ·10.sup.-ΔE/30 potassium ions: A=-0.130 to -0.065 calcium ions: A=-0.240 to -0.172 wherein ΔE: is the potential difference when an ionic strength of 150 mM is used as the standard; μ: is the ionic strength; C o : is the calibrated concentration; C: is the concentration of reagent added; and A: is the correction factor.
Claim 2
Dependent Claim
135 words
A standard solution for simultaneously calibrating a plurality of ion electrodes for determining a plurality of ions, which includes at least potassium ions and calcium ions in blood, said standard solution consisting essentially of an aqueous solution of sodium chloride, potassium chloride, calcium carbonate, Tris(hydroxy)aminomethane and hydrochloric acid, wherein the concentration of the standard solution for the potassium ion electrode and the calcium ion electrode is adjusted in accordance with the following equations: ##EQU4## potassium ions: C=C.sub.o ·10.sup.-ΔE/60 calcium ions: C=C.sub.o ·10.sup.-ΔE/30 potassium ions: A=-0.130 to -0.065 calcium ions: A=-0.240 to -0.172 wherein ΔE: is the potential difference when an ionic strength of 150 mM is used as the standard; μ: is the ionic strength; C o : is the calibrated concentration; C: is the concentration of reagent added; and A: is the correction factor.
Claim 3
Dependent Claim
17 words
A standard solution according to claim 1 wherein the solution also contains a polyethylene glycol mono-p-nonylphenyl ether.
Claim 4
Dependent Claim
17 words
A standard solution according to claim 2 wherein the hydrochloric acid is present as a 1 N-solution.
Claim 5
Dependent Claim
27 words
A standard solution according to claim 1 used for simultaneously calibrating an Na + electrode, a K + electrode, a Ca ++ electrode, and a pH electrode.
References Cited (Backward Citations)
JPS5635052A
Cited
US4363633A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-12-01 | 1990-06-02 | 1990-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-12-01 | 1994-06-02 | 1994-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-12-01 | 1998-06-02 | 1998-12-02 | $7700.00 | Window Closed / Lapsed |