US4623651A
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Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1985-10-15
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Granted: 1986-11-18
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Expires: 2005-10-15
Abstract
Abstract Heterocyclocarbonyl- and acetyl-thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
Inventors
- 👤 J. Martin Grisar
- 👤 Richard C. Dage
- 👤 Richard A. Schnettler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:18
CPC Classifications
C; C07; C07D; C07D407/00; C07D407/02; C07D417/00; C07D417/02; C07D417/06; A; A61; A61P; A61P9/00; A61P9/04
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
84 words
A thiazolone of the formula ##STR5## wherein is a hydrogen or (C 1 -C 4 )alkyl group and R 2 is a pyridyl or pyridylmethyl group optionally substituted with a member of the group consisting of a (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkylthio, (C 1 -C 4 )alkylsulfinyl, (C 1 -C 4 )alkylsulfonyl, carboxy, carb (C 1 -C 4 )alkoxy, halogen, trifluoromethyl and cyano, or R 2 is a furanyl, furanylmethyl, thienyl or thienylmethyl group.
Claim 2
Dependent Claim
84 words
A thiazolone of the formula ##STR5## wherein is a hydrogen or (C 1 -C 4 )alkyl group and R 2 is a pyridyl or pyridylmethyl group optionally substituted with a member of the group consisting of a (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )alkylthio, (C 1 -C 4 )alkylsulfinyl, (C 1 -C 4 )alkylsulfonyl, carboxy, carb (C 1 -C 4 )alkoxy, halogen, trifluoromethyl and cyano, or R 2 is a furanyl, furanylmethyl, thienyl or thienylmethyl group.
Claim 3
Dependent Claim
15 words
A thiazolone of claim 1 wherein R 1 is a hydrogen, methyl, or ethyl group.
Claim 4
Dependent Claim
15 words
A thiazolone of claim 1 wherein R 2 is a pyridyl or substituted pyridyl group.
Claim 5
Dependent Claim
15 words
A thiazolone of claim 2 wherein R 2 is a pyridyl or substituted pyridyl group.
Claim 6
Dependent Claim
12 words
A thiazolone of claim 1 wherein R 2 is a 4-pyridyl group.
Claim 7
Dependent Claim
12 words
A thiazolone of claim 2 wherein R 2 is a 4-pyridyl group.
Claim 8
Dependent Claim
19 words
A thiazolone of claim 1 wherein R 1 is a methyl group and R 2 is a 4-pyridyl group.
Claim 9
Dependent Claim
28 words
A method of enhancing myocardial contractile force in a patient in need thereof which comprises administering to the patient an effective amount of a thiazolone of claim 1.
Claim 10
Dependent Claim
15 words
A method of claim 8 wherein R 1 is a hydrogen, methyl, or ethyl group.
Claim 11
Dependent Claim
15 words
A method of claim 8 wherein R 2 is a pyridyl or substituted pyridyl group.
Claim 12
Dependent Claim
15 words
A method of claim 9 wherein R 2 is a pyridyl or substituted pyridyl group.
Claim 13
Dependent Claim
12 words
A method of claim 8 wherein R 2 is a 4-pyridyl group.
Claim 14
Dependent Claim
12 words
A method of claim 9 wherein R 2 is a 4-pyridyl group.
Claim 15
Dependent Claim
19 words
A method of claim 8 wherein R 1 is a methyl group and R 2 is a 4-pyridyl group.
Claim 16
Dependent Claim
28 words
A method of treating heart disfunction in a patient in need thereof which comprises administering to the patient a cardiotonically effective amount of a thiazolone of claim 1.
Claim 17
Dependent Claim
15 words
A method of claim 15 wherein R 1 is a hydrogen, methyl, or ethyl group.
Claim 18
Dependent Claim
15 words
A method of claim 15 wherein R 2 is a pyridyl or substituted pyridyl group.
Claim 19
Dependent Claim
15 words
A method of claim 16 wherein R 2 is a pyridyl or substituted pyridyl group.
Claim 20
Dependent Claim
12 words
A method of claim 15 wherein R 2 is a pyridyl group.
Claim 21
Dependent Claim
12 words
A method of claim 16 wherein R 2 is a pyridyl group.
Claim 22
Dependent Claim
20 words
A method of claim 15 wherein R 1 is a methyl group and wherein R 2 is a 4-pyridyl group.
References Cited (Backward Citations)
US4405635A
Cited
US4405638A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-11-17 | 1990-05-19 | 1990-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-11-17 | 1994-05-19 | 1994-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-11-17 | 1998-05-19 | 1998-11-18 | $7700.00 | Window Closed / Lapsed |