US4405638A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Methoxyphenyl esters of N-substituted amino acids, a process for their preparation and pharmaceutical compositions containing them
Assignee: Sigma Tau Industrie Farmaceutiche Riunite SpA
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Filing: 1982-04-29
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Granted: 1983-09-20
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Expires: 2002-04-29
Abstract
Abstract The invention provides 2-methoxyphenyl esters of N-substituted amino acids, which have mucolytic, antitussive and antiinflammatory activity.
Inventors
- 👤 Claudio Cavazza
- 👤 Massimo Carloni
- 👤 Maria T. Ramacci
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:18
CPC Classifications
C; C07; C07C; C07C231/00; C07C231/12; C07D; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/38
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
33 words
2-methoxyphenyl esters of formula I ##STR9## in which: R is hydrogen, --CH 3 or --CH 2 SR", wherein R" represents hydrogen, --COCH 3 or --CH 2 COOH; R' is --CH 3 or ##STR10##
Claim 2
Dependent Claim
33 words
2-methoxyphenyl esters of formula I ##STR9## in which: R is hydrogen, --CH 3 or --CH 2 SR", wherein R" represents hydrogen, --COCH 3 or --CH 2 COOH; R' is --CH 3 or ##STR10##
Claim 3
Dependent Claim
12 words
As a new compound according to claim 1, the 2-methoxyphenylester of N-acetylglycine.
Claim 4
Dependent Claim
12 words
As a new compound according to claim 1, the 2-methoxyphenylester of N-[2-(2-thenoylthio)propionyl]glycine.
Claim 5
Dependent Claim
12 words
As a new compound according to claim 1, the 2-methoxyphenylester of N-acetylalanine.
Claim 6
Dependent Claim
12 words
As a new compound according to claim 1, the 2-methoxyphenylester of N-[2-(2-thenoylthio)propionyl]alanine.
Claim 7
Dependent Claim
12 words
As a new compound according to claim 1, the 2-methoxyphenylester of N-acetylcysteine.
Claim 8
Dependent Claim
12 words
As a new compound according to claim 1, the 2-methoxyphenylester of N,S-diacetylcysteine.
Claim 9
Dependent Claim
12 words
As a new compound according to claim 1, the 2-methoxyphenylester of N-acetyl-S-carboxymethylcysteine.
Claim 10
Dependent Claim
12 words
As a new compound according to claim 1, the 2-methoxyphenylester of N-[2-(2-thenoylthio)propionyl]cysteine.
Claim 11
Dependent Claim
12 words
As a new compound according to claim 1, the 2-methoxyphenylester of N-[2-(2-thenoylthio)propionyl]-S-acetylcysteine.
Claim 12
Dependent Claim
12 words
As a new compound according to claim 1, the 2-methoxyphenylester of N-[2-(2-thenoylthio)propionyl]-S-carboxymethylcysteine.
Claim 13
Dependent Claim
33 words
Pharmaceutical compositions with mucolytic, bronchosecretogogic and antitussive activity, characterized by the fact that an ester of formula I ##STR11## wherein R and R' are as above indicated, is contained as the active ingredient.
Claim 14
Dependent Claim
33 words
Pharmaceutical compositions with mucolytic, bronchosecretogogic and antitussive activity, characterized by the fact that an ester of formula I ##STR11## wherein R and R' are as above indicated, is contained as the active ingredient.
Claim 15
Dependent Claim
13 words
Pharmaceutical compositions according to claim 12, in the pharmaceutical dosage form of suppositoires.
Claim 16
Dependent Claim
13 words
Pharmaceutical compositions according to claim 12, in the pharmaceutical dosage form of aerosol.
Claim 17
Dependent Claim
14 words
Pharmaceutical compositions according to claim 12, in the pharmaceutical dosage form of injectable ampuls.
Claim 18
Dependent Claim
13 words
Pharmaceutical compositions according to claim 12, in the pharmaceutical dosage form of syrups.
References Cited (Backward Citations)
US4108886A
Cited
US4279842A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-19 | 1987-03-21 | 1987-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-19 | 1991-03-21 | 1991-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-19 | 1995-03-21 | 1995-09-20 | $7700.00 | Window Closed / Lapsed |