Patent US2585956A successfully refreshed from Google Patents.
Patent US4620974A successfully refreshed from Google Patents.
US4620974A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical composition containing a liquid lubricant
Assignee: Wyeth LLC
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Filing: 1985-05-03
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Granted: 1986-11-04
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Expires: 2005-05-03
Abstract
Abstract Pharmaceutical compositions produced with liquid, hydrophilic lubricants possessing markedly improved dissolution rates.
Inventors
- 👤 Marvin Hersh
- 👤 Charles W. Lentine
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:22
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/4841; A61K9/4866; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K9/20; A61K9/2004; A61K9/2013
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
72 words
A hard gelatin, telescoping two-piece cap and body capsule filled with a solid pharmaceutical composition free of solid hydrophobic lubricant comprising a dry, powdery, dust-producing therapeutic agent in intimate admixture with a non-solubilizing amount of a pharmaceutically acceptable, liquid, hydrophilic, dust-reducing, lubricant, said lubricant being a polyethylene glycol of molecular weight from about 200 to about 900, present in said admixture in from about 0.5 to about 25 weight percent of composition.
Claim 2
Dependent Claim
72 words
A hard gelatin, telescoping two-piece cap and body capsule filled with a solid pharmaceutical composition free of solid hydrophobic lubricant comprising a dry, powdery, dust-producing therapeutic agent in intimate admixture with a non-solubilizing amount of a pharmaceutically acceptable, liquid, hydrophilic, dust-reducing, lubricant, said lubricant being a polyethylene glycol of molecular weight from about 200 to about 900, present in said admixture in from about 0.5 to about 25 weight percent of composition.
Claim 3
Dependent Claim
27 words
A filled hard gelatin capsule of claim 1 in which said lubricant is a polyethylene glycol which possesses a molecular weight of about 380 to about 420.
Claim 4
Dependent Claim
19 words
A filled hard gelatin capsule of claim 1 in which said admixture contains a pharmaceutically acceptable surface active agent.
Claim 5
Dependent Claim
47 words
A filled hard gelatin capsule of claim 1 in which said surface active agent is a fatty ester of polyoxyethylene sorbitan, a polyoxyethylene condensate of a hydrophobic base formed by polymerization of propylene oxide and propylene glycol, sorbitan monolaurate, octylphenoxypolyethoxy ethanol, cetylpyridinium chloride or dioctyl sodium sulfosuccinate.
Claim 6
Dependent Claim
15 words
A filled hard gelatin capsule of claim 1 in which said therapeutic agent is oxazepam.
Claim 7
Dependent Claim
59 words
A filled hard gelatin capsule of claim 1 in which said solid pharmaceutical composition comprises from about 10 to about 30 milligrams oxazepam, about 0.5 to about 25 weight percent of composition of liquid polyethylene glycol of molecular weight from about 200 to about 900, about 0.1 to about 25 weight percent of composition of surfactant, plus a filler.
Claim 8
Dependent Claim
61 words
A filled hard gelatin capsule of claim 1 in which said solid pharmaceutical composition comprises from about 10 to about 30 milligrams oxazepam, about 3 to about 11 weight percent ratio to active of polyethylene glycol lubricant of molecular weight from about 380 to 420, about 0.5 to about 2.5 weight percent ratio to active of nonionic surfactant, and a filler.
Claim 9
Dependent Claim
54 words
A filled hard gelatin capsule of claim 7 in which said solid pharmaceutical composition comprises about 10 milligrams oxazepam, about 167 milligrams lactose, about 6.6 milligrams croscarmellose sodium, about 1.1 milligram polyethylene glycol of molecular weight from about 380 to about 420 and about 0.22 milligrams of a fatty ester of polyoxyethylene sorbitan surfactant.
Claim 10
Dependent Claim
54 words
A filled hard gelatin capsule of claim 7 in which said solid pharmaceutical composition comprises about 15 milligrams oxazepam, about 162 milligrams lactose, about 6.6 milligrams croscarmellose sodium, about 1.1 milligram polyethylene glycol of molecular weight from about 380 to about 420 and about 0.22 milligrams of a fatty ester of polyoxyethylene sorbitan surfactant.
Claim 11
Dependent Claim
54 words
A filled hard gelatin capsule of claim 7 in which said solid pharmaceutical composition comprises about 30 milligrams oxazepam, about 147 milligrams lactose, about 6.6 milligrams croscarmellose sodium, about 1.1 milligram polyethylene glycol of molecular weight from about 380 to about 420 and about 0.22 milligrams of a fatty ester of polyoxyethylene sorbitan surfactant.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-11-03 | 1990-05-05 | 1990-11-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-11-03 | 1994-05-05 | 1994-11-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-11-03 | 1998-05-05 | 1998-11-04 | $7700.00 | Window Closed / Lapsed |