US4614732A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N6 -acenaphthyl adenosines and analogs thereof
Assignee: Warner Lambert Co LLC
•
Filing: 1985-09-05
•
Granted: 1986-09-30
•
Expires: 2005-09-05
Abstract
Abstract N 6 -acenaphthyl adenosines and analogs thereof and pharmaceutically acceptable acid addition salts having highly desirable blood pressure lowering properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
Inventors
- 👤 Harriet W. Hamilton
- 👤 William C. Patt
- 👤 Bharat K. Trivedi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 06:26
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
95 words
A compound of the formula ##STR7## wherein: is optionally a double or single bond; n=0-4; X, X', Y, Y' are each independently H, OH, halogen, amino, nitro, lower alkyl, trifluoromethyl or lower alkoxy; R 1 is H, alkyl, OH or lower alkoxy; R 2 is H or halogen; R 2 ', R 3 ', and R 5 ' are each independently hydrogen, alkanoyl, benzoyl, benzoyl substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R 2 ' and R 3 ' together may be 2', 3'-isopropylidene, or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
95 words
A compound of the formula ##STR7## wherein: is optionally a double or single bond; n=0-4; X, X', Y, Y' are each independently H, OH, halogen, amino, nitro, lower alkyl, trifluoromethyl or lower alkoxy; R 1 is H, alkyl, OH or lower alkoxy; R 2 is H or halogen; R 2 ', R 3 ', and R 5 ' are each independently hydrogen, alkanoyl, benzoyl, benzoyl substituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl, or R 2 ' and R 3 ' together may be 2', 3'-isopropylidene, or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
14 words
A compound according to claim 1, wherein X, X', Y, and Y' are hydrogen.
Claim 4
Dependent Claim
15 words
A compound according to claim 2, wherein R 1 is hydrogen and n is zero.
Claim 5
Dependent Claim
15 words
A compound according to claim 2 wherein R 1 is hydrogen and n is one.
Claim 6
Dependent Claim
11 words
A compound according to claim 3, wherein R 2 is hydrogen.
Claim 7
Dependent Claim
37 words
A compound according to claim 5, wherein R 2 ', R 3 ', and R 5 ' are each independently hydrogen, acetyl or benzoyl, or R 2 ' and R 3 ' when taken together are isopropylidene.
Claim 8
Dependent Claim
11 words
A compound according to claim 6 and being N 6 -(acenaphthyl)adenosine.
Claim 9
Dependent Claim
37 words
A compound according to claim 4 wherein R 2 ', R 3 ', and R 5 ' are each independently hydrogen, acetyl or benzoyl, or R 2 ' and R 3 ' when taken together are isopropylidene.
Claim 10
Dependent Claim
11 words
A compound according to claim 8 and being N 6 -(1-acenaphthylenylmethyl)adenosine.
Claim 11
Dependent Claim
11 words
A compound according to claim 9 and being N 6 -[(1,2-dihydro-1-acenaphthylenyl)methyl]adenosine.
Claim 12
Dependent Claim
25 words
A pharmaceutical composition for treating hypertension comprising an antihypertensive effective amount of a compound as claimed in claim 1 together with a pharmaceutically acceptable carrier.
Claim 13
Dependent Claim
32 words
A method for treating hypertension in a mammal suffering therefrom, which comprises administering to such mammals an antihypertensive effective amount of a compound as claimed in claim 1 in unit dosage form.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-29 | 1990-03-31 | 1990-09-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-29 | 1994-03-31 | 1994-09-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-29 | 1998-03-31 | 1998-09-30 | $7700.00 | Window Closed / Lapsed |