US4614650A
Expired / Lapsed
US
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Cytotoxic composition including at least an immunotoxine and an amine
Assignee: Elf Sanofi SA
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Filing: 1983-03-07
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Granted: 1986-09-30
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Expires: 2003-03-07
Abstract
Abstract PCT No. PCT/FR83/00043 Sec. 371 Date Nov. 9, 1983 Sec. 102(e) Date Nov. 9, 1983 PCT Filed Mar. 7, 1983 PCT Pub. No. WO83/03200 PCT Pub. Date Sep. 29, 1983.The present invention relates to cytotoxic medicines characterized in that they contain in association at least an immunotoxine and an amine or a pharmaceutically acceptable salt of said amine.
Inventors
- 👤 Franz Jansen
- 👤 Pierre Gros
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 16:30
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6811; A61K47/6817; A61P; A61P35/00
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
93 words
A cytotoxic composition comprising a cytotoxic amount of an immunotoxin and 10 mg to 2 g of an amine of the formula R 1 NHR 2 in which R 1 designates hydrogen or lower alkyl and R 2 designates lower alkyl, or the formula R 1 NHR 2 represents 1-aminoadmantane, said amine being used in the form of the amine or a pharmcentically acceptable amine scale, said immunotixin comprising the A chain of ricin covalently bonded to an antibody or an antibody fragment directed against an antigen in the cell to be destroyed.
Claim 2
Dependent Claim
93 words
A cytotoxic composition comprising a cytotoxic amount of an immunotoxin and 10 mg to 2 g of an amine of the formula R 1 NHR 2 in which R 1 designates hydrogen or lower alkyl and R 2 designates lower alkyl, or the formula R 1 NHR 2 represents 1-aminoadmantane, said amine being used in the form of the amine or a pharmcentically acceptable amine scale, said immunotixin comprising the A chain of ricin covalently bonded to an antibody or an antibody fragment directed against an antigen in the cell to be destroyed.
Claim 3
Dependent Claim
20 words
A pharmaceutical composition according to claim 1, characterized in that the amine used is methylamine or one of its salts.
Claim 4
Dependent Claim
19 words
A pharmaceutical composition according to claim 1, characterized in that it is packaged for administration by the injectable route.
Claim 5
Dependent Claim
19 words
A pharmaceutical composition according to claim 1, characterized in that it is packaged for administration by the intravenous route.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-29 | 1990-03-31 | 1990-09-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-29 | 1994-03-31 | 1994-09-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-29 | 1998-03-31 | 1998-09-30 | $7700.00 | Window Closed / Lapsed |