US4485093A
Expired / Lapsed
US
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Immunotoxin conjugate which comprises arsanilic acid, useful for treating malignant tumors, particularly pancreatic cancer
Assignee: Individual
•
Filing: 1982-08-13
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Granted: 1984-11-27
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Expires: 2002-08-13
Abstract
Abstract An immunotoxin conjugate, useful for treating malignant tumors in mammals, which consists of arsanilic acid and tumor specific antibodies covalently bound to a polyglutamic acid linking agent is taught. The conjugate selectively delivers arsanilic acid to a tumor, killing the tumor cells and exhibiting little or no toxicity to normal cells. The conjugate is effective in treating human pancreatic cancer.
Inventors
- 👤 Richard G. Runge
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 16:35
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6835; A61K47/6883
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
57 words
A water soluble immunotoxin conjugate consisting of arsanilic acid, polyglutamic acid, and a tumor specific antibody wherein: (1) polyglutamic acid having a molecular weight from about 2,000 to about 35,000 covalently binds the antibody and the arsanilic acid via carboxyl groups on the polyglutamic acid: and (2) the arsanilic acid is present in a tumor toxic amount.
Claim 2
Dependent Claim
57 words
A water soluble immunotoxin conjugate consisting of arsanilic acid, polyglutamic acid, and a tumor specific antibody wherein: (1) polyglutamic acid having a molecular weight from about 2,000 to about 35,000 covalently binds the antibody and the arsanilic acid via carboxyl groups on the polyglutamic acid: and (2) the arsanilic acid is present in a tumor toxic amount.
Claim 3
Dependent Claim
20 words
The immunotoxin conjugate of claim 1 wherein the polyglutamic acid has a molecular weight from about 4,000 to about 15,000.
Claim 4
Dependent Claim
37 words
The immunotoxin conjugate of claim 1 wherein said carboxyl groups on the polyglutamic acid are activated by reaction with a carbodiimide prior to binding with arsanilic acid and prior to binding with the tumor specific antibody respectively.
Claim 5
Dependent Claim
13 words
The immunotoxin conjugate of claim 3 wherein the carbodiimide is 1-ethyl-3(3-dimethyl aminopropyl) carbodiimide.
Claim 6
Independent Claim
75 words
A method of treating tumors in mammals comprising parenterally administering to the mammal a tumor toxic effective amount of a watersoluble immunotoxin conjugate consisting of arsanilic acid, polyglutamic acid, and a tumor specific antibody wherein: (1) polyglutamic acid having a molecular weight from about 2,000 to about 35,000 covalently binds the antibody and the arsanilic acid via carboxyl groups on the polyglutamic acid and (2) the arsanilic acid is present in a tumor toxic amount.
Claim 7
Independent Claim
75 words
A method of treating tumors in mammals comprising parenterally administering to the mammal a tumor toxic effective amount of a watersoluble immunotoxin conjugate consisting of arsanilic acid, polyglutamic acid, and a tumor specific antibody wherein: (1) polyglutamic acid having a molecular weight from about 2,000 to about 35,000 covalently binds the antibody and the arsanilic acid via carboxyl groups on the polyglutamic acid and (2) the arsanilic acid is present in a tumor toxic amount.
Claim 8
Dependent Claim
19 words
The method of claim 5 wherein the polyglutamic acid has a molecular weight from about 4,000 to about 15,000.
Claim 9
Dependent Claim
37 words
The method of claim 5 wherein said carboxyl groups on the polyglutamic acid are activated by reaction with a carbodiimide prior to binding with the arsanilic acid and prior to binding with the tumor specific antibody respectively.
Claim 10
Dependent Claim
12 words
The method of claim 7 wherein the carbodiimide is 1-ethyl-3(3-dimethyl aminopropyl) carbodiimide.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-11-27 | 1988-05-28 | 1988-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-11-27 | 1992-05-28 | 1992-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-11-27 | 1996-05-28 | 1996-11-27 | $7700.00 | Window Closed / Lapsed |