US4611008A
Expired / Lapsed
US
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Preparation of nitroesters for coronary artery therapy
Assignee: Dynamit Nobel AG
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Filing: 1984-09-14
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Granted: 1986-09-09
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Expires: 2004-09-14
Abstract
Abstract A gel or gel preparation of improved stability and shelf life having an action on the coronary arteries comprising nitroesters, an oil base and finely disperse silica, wherein the finely disperse silica contains hydrophilic and hydrophobic, finely disperse silica is disclosed. A method for making the gel preparation is also disclosed.
Inventors
- 👤 Walter Heinzelmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 00:02
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K47/00; A61K47/02; A61K47/06; A61K47/08; A61K47/14; A61K9/00; A61K9/0012; A61K9/0014; A61P; A61P9/00; A61P9/08; A61P9/10
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
84 words
A gel-containing preparation comprising a coronary-active nitroester selected from the group consisting of nitroglycerin, pentaerythritol tetranitrate and nitroesters of 1,4,3,6-dianhydrosorbide, a pharmaceutically acceptable oil base, and finely disperse silica in the ratio of: (a) 0.5 to 25.0 wt.-parts of the nitroester, to (b) 55.0 to 90.0 wt.-parts of the oil base, to (c) 5.0 to 40.0 wt.-parts of the finely disperse silica, wherein the finely disperse silica consists of 95.0 to 60.0 wt.-% of hydrophilic silica and 5.0 to 40.0 wt.-% of hydrophobic silica.
Claim 2
Dependent Claim
84 words
A gel-containing preparation comprising a coronary-active nitroester selected from the group consisting of nitroglycerin, pentaerythritol tetranitrate and nitroesters of 1,4,3,6-dianhydrosorbide, a pharmaceutically acceptable oil base, and finely disperse silica in the ratio of: (a) 0.5 to 25.0 wt.-parts of the nitroester, to (b) 55.0 to 90.0 wt.-parts of the oil base, to (c) 5.0 to 40.0 wt.-parts of the finely disperse silica, wherein the finely disperse silica consists of 95.0 to 60.0 wt.-% of hydrophilic silica and 5.0 to 40.0 wt.-% of hydrophobic silica.
Claim 3
Dependent Claim
29 words
The preparation of claim 1, wherein the finely disperse silica consits of 80 to 60 wt.-% of a hydrophilic silica and 20 to 40 wt.-% of a hydrophobic silica.
Claim 4
Dependent Claim
13 words
The preparation of claim 1, containing 1.0 to 10.0 wt.-% of dissolved nitroesters.
Claim 5
Dependent Claim
13 words
The preparation of claim 2, containing 1.0 to 10.0 wt.-% of dissolved nitroesters.
Claim 6
Dependent Claim
13 words
The preparation of claim 1, containing 2.0 to 5.0 wt.-% of dissolved nitroesters.
Claim 7
Dependent Claim
13 words
The preparation of claim 2, containing 2.0 to 5.0 wt.-% of dissolved nitroesters.
Claim 8
Dependent Claim
24 words
The preparation of claim 1, further comprising a solid carrier substance for the nitroesters, in amounts of up to 85 wt.-% of the preparation.
Claim 9
Dependent Claim
26 words
The preparation of claim 1, wherein the oil base consists of a pharmaceutically acceptable oily liquid substance which is fluid between -10° C. and +30° C.
Claim 10
Dependent Claim
28 words
The preparation of claim 7, wherein the oil base consists of a triglyceride of a saturated straight-chain fatty acid of chain length C 8 to C 10 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-08 | 1990-03-10 | 1990-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-08 | 1994-03-10 | 1994-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-08 | 1998-03-10 | 1998-09-09 | $7700.00 | Window Closed / Lapsed |