US4112115A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapy of leg muscle cramps
Assignee: Individual
•
Filing: 1976-11-08
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Granted: 1978-09-05
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Expires: 1996-11-08
Abstract
Abstract Spasms in flexor and extensor muscles such as calf muscles are alleviated by topically administering to the surface of the adjacent skin a nitrite vasodilator agent, such as glyceryl trinitrate, in a suitable carrier.
Inventors
- 👤 Charles C. Coghlan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 05:09
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K9/00; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
42 words
A method of alleviating spasms in flexor and extensor muscles comprising the step of topically administering to the surface of the skin adjacent said muscle a spasms alleviating amount of a solution of a nitrite vasodilator agent in a pharmacologically acceptable carrier.
Claim 2
Independent Claim
42 words
A method of alleviating spasms in flexor and extensor muscles comprising the step of topically administering to the surface of the skin adjacent said muscle a spasms alleviating amount of a solution of a nitrite vasodilator agent in a pharmacologically acceptable carrier.
Claim 3
Dependent Claim
38 words
The method in accordance with claim 1 wherein said nitrite vasodilator agent is selected from the group consisting of glyceryl trinitrate, amyl nitrite, glycol dinitrate, mannitol hexanitrate, erythrityl tetranitrate, pentaerythritol tetranitrate, isosorbide dinitrate, triethanolamine trinitrate and mixtures thereof.
Claim 4
Dependent Claim
22 words
The method in accordance with claim 1 wherein said carrier is selected from the group consisting of aqueous ethanol and aqueous isopropanol.
Claim 5
Dependent Claim
28 words
The method in accordance with claim 3 in which said carrier liquid consists from about 50% by volume to about 85% by volume of said ethanol or isopropanol.
Claim 6
Dependent Claim
15 words
The method in accordance with claim 1 wherein said nitrite vasodilator agent is glyceryl trinitrate.
Claim 7
Dependent Claim
31 words
The method in accordance with claim 1 wherein said nitrite vasodilator agent is present in said carrier at a concentration of from about 0.5 to about 5 grams per 100 cc.
Claim 8
Dependent Claim
14 words
The method in accordance with claim 4 wherein the nitrite vasodilator is glyceryl trinitrate.
Claim 9
Dependent Claim
38 words
The method in accordance with claim 6 wherein the nitrite vasodilator is glyceryl trinitrate and the carrier liquid consists of from about 50% by volume to about 85% by volume of alcohol in aqueous ethanol or aqueous isopropanol.
Claim 10
Dependent Claim
34 words
The method in accordance with claim 1 wherein the solution of a nitrite vasodilator consists of 1 gram glyceryl trinitrate, 1 gram methylsalicylate and enough 70% aqueous ethanol to make 100 cc. of solution.
Claim 11
Dependent Claim
21 words
The method in accordance with claim 1 wherein the nitrite vasodilator agent is present at a concentration of 1 gram/100 cc.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-04 | 1982-03-06 | 1982-09-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-04 | 1986-03-06 | 1986-09-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-04 | 1990-03-06 | 1990-09-05 | $7700.00 | Window Closed / Lapsed |