US4609664A
Expired / Lapsed
US
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Antiasthmatic piperidylidene derivatives
Assignee: Sandoz AG
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Filing: 1984-07-16
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Granted: 1986-09-02
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Expires: 2004-07-16
Abstract
Abstract Piperidylidene derivatives of formula <IMAGE> wherein n is 2 or 3, R1 comprises a tricyclic nucleus and R2 is hydrogen or an acid residue, useful in the treatment and prophylaxis of asthmatic conditions.
Inventors
- 👤 Klaus Hasspacher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 05:16
CPC Classifications
C; C07; C07D; C07D495/00; C07D495/02; C07D495/04; A; A61; A61P; A61P11/00; A61P11/14; A61P37/00; A61P37/08; C07D211/00; C07D211/04; C07D211/68; C07D211/70
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
37 words
A compound of formula I ##STR20## wherein n is 3, R 1 is ##STR21## and R 2 is hydrogen or a physiologically acceptable and-hydroloysable acid residue, in free base or in pharmaceutically acceptable acid addition salt form.
Claim 2
Dependent Claim
37 words
A compound of formula I ##STR20## wherein n is 3, R 1 is ##STR21## and R 2 is hydrogen or a physiologically acceptable and-hydroloysable acid residue, in free base or in pharmaceutically acceptable acid addition salt form.
Claim 3
Dependent Claim
11 words
A compound according to claim 1 wherein R 2 is hydrogen.
Claim 4
Dependent Claim
33 words
A compound according to claim 1 of the formula ##STR22## where R 2 is hydrogen or a physiologically-acceptable and hydrolysable acid residue, in free base or in pharmaceutically acceptable acid addition salt form.
Claim 5
Dependent Claim
33 words
A compound according to claim 1 of the formula ##STR23## where R 2 is hydrogen or a physiologically-acceptable and hydrolysable acid residue, in free base or in pharmaceutically acceptable acid addition salt form.
Claim 6
Dependent Claim
10 words
A compound according to claim 3, which is 4-{2-[2-[2-[4-(5H-dibenzo[a,d]cyclohept-5-ylidene)piperidin-1-yl]ethoxy]ethoxy]ethoxy}-4-oxo-butanoic acid.
Claim 7
Dependent Claim
18 words
A compound according to claim 4 which is 4-{1-[2-[2-(2-hydroxy-ethoxy)ethoxy]ethyl]piperidin-4-yliden}-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-(9H)-one, in free base or in acid addition salt form.
Claim 8
Dependent Claim
18 words
A compound according to claim 3 which is 2-{2-[2-[4-(5H-dibenzo[a,d]cyclohept-5-yliden)piperidin-1-yl]-ethoxy]ethoxy}ethanol, in free base or in acid addition salt form.
Claim 9
Dependent Claim
56 words
A pharmaceutical composition useful in the treatment or prophylaxis of asthma, allergic conditions, and allergic asthma comprising a compound according to claim 1 in free base or pharmaceutically acceptable acid addition salt form, in an amount effective for the treatment of asthma, allergic conditions, and allergic asthma together with a pharmaceutically acceptable diluent or carrier therefor.
Claim 10
Dependent Claim
44 words
A method for the treatment or prophylaxis of asthma in a subject in need of such treatment, which method comprises administering to said subject an effective amount of a compound according to claim 1 in free base or pharmaceutically acceptable acid addition salt form.
Claim 11
Dependent Claim
45 words
A method for the treatment or prophylaxis of allergic conditions in a subject in need of such treatment, which method comprises administering to said subject an effective amount of a compound according to claim 1 in free base or pharmaceutically acceptable acid addition salt form.
Claim 12
Dependent Claim
45 words
A method for the treatment or prophylaxis of allergic asthma in a subject in need of such treatment, which method comprises administering to said subject an effective amount of a compound according to claim 1 in free base or pharmaceutically acceptable acid addition salt form.
References Cited (Backward Citations)
CA746508A
Cited
CA780441A
Cited
FR1488972A
Cited
GB1117259A
Cited
DE2256392A1
Cited
US4273780A
Cited
US4128549A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1989-09-01 | 1990-03-03 | 1990-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-01 | 1994-03-03 | 1994-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-01 | 1998-03-03 | 1998-09-02 | $7700.00 | Window Closed / Lapsed |