US4128549A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Precursors of 4-(1-alkyl-4-piperidylidene-4H-benzo[4,5]cyclohepta-[1,2-b]thiophen-10(9H)-ones
Assignee: Sandoz AG
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Filing: 1977-02-03
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Granted: 1978-12-05
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Expires: 1997-02-03
Abstract
Abstract The present invention concerns a novel process for the production of known benzocycloheptathiophene derivatives of the formula: ##STR1## wherein R 1 is hydrogen, chlorine, bromine or alkoxy, and R 2 is alkyl. The compounds are useful as specific histaminolytics for use in the treatment of allergic conditions.
Inventors
- 👤 Jean-Pierre Bourquin
- 👤 Gustav Schwarb
- 👤 Erwin Waldvogel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 17:22
CPC Classifications
C; C07; C07D; C07D333/00; C07D333/50; C07D333/78; C07D333/80
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
44 words
A compound of the formula: ##STR11## wherein R 1 is in the 6 or 7 position of the benzocycloheptathiophene nucleus and is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms, and R 2 is alkyl of 1 to 4 carbon atoms.
Claim 2
Dependent Claim
44 words
A compound of the formula: ##STR11## wherein R 1 is in the 6 or 7 position of the benzocycloheptathiophene nucleus and is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms, and R 2 is alkyl of 1 to 4 carbon atoms.
Claim 3
Dependent Claim
54 words
A compound of the formula: ##STR12## wherein R 1 is in the 6 or 7 position of the cycloheptathiophene nucleus and is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms, R 2 is alkyl of 1 to 4 carbon atoms, and R 3 is alkyl of 1 to 4 carbon atoms.
Claim 4
Dependent Claim
54 words
A compound of the formula: ##STR12## wherein R 1 is in the 6 or 7 position of the cycloheptathiophene nucleus and is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms, R 2 is alkyl of 1 to 4 carbon atoms, and R 3 is alkyl of 1 to 4 carbon atoms.
Claim 5
Dependent Claim
8 words
The compound of claim 2, which is 10-methoxy-4-(1-methyl-4-piperidyl)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ol.
Claim 6
Dependent Claim
44 words
A compound of the formula: ##STR13## wherein R 1 is in the 6 or 7 position of the cycloheptathiophene nucleus and is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms, and R 3 is alkyl of 1 to 4 carbon atoms.
Claim 7
Dependent Claim
44 words
A compound of the formula: ##STR13## wherein R 1 is in the 6 or 7 position of the cycloheptathiophene nucleus and is hydrogen, chlorine, bromine or alkoxy of 1 to 4 carbon atoms, and R 3 is alkyl of 1 to 4 carbon atoms.
Claim 8
Dependent Claim
9 words
The compound of claim 4, which is 10-methoxy-4H-benzo[4,5]cyclohepta[1,2-b] thiophen-4-one.
Claim 9
Dependent Claim
8 words
The compound of claim 4 which is 6-chloro-10-methoxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one.
Claim 10
Dependent Claim
9 words
The compound of claim 4 which is 7-chloro-10-methoxy-4H-benzo[4,5]cyclohepta[1,2-b] thiophen-4-one.
Claim 11
Dependent Claim
9 words
The compound of claim 4 which is 6-bromo-10-methoxy-4H-benzo[4,5]cyclohepta[1,2-b] thiophen-4-one.
Claim 12
Dependent Claim
9 words
The compound of claim 4 which is 7,10-dimethoxy-4H-benzo[4,5]cyclohepta[1,2-b] thiophen-4-one.
Claim 13
Dependent Claim
9 words
The compound of claim 4 which is 10-butoxy-4H-benzo[4,5]cyclohepta[1,2-b] thiophen-4-one.
Claim 14
Dependent Claim
9 words
The compound of claim 4 which is 10-ethoxy-4H-benzo[4,5]cyclohepta[1,2-b] thiophen-4-one.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-12-04 | 1982-06-05 | 1982-12-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-12-04 | 1986-06-05 | 1986-12-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-12-04 | 1990-06-05 | 1990-12-05 | $7700.00 | Window Closed / Lapsed |