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US4609547A
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Anti-allergic compositions and their use
Assignee: Beecham Group PLC
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Filing: 1984-04-26
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Granted: 1986-09-02
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Expires: 2004-04-26
Abstract
Abstract Pharmaceutical compositions are described for anti-allergy therapy comprising an allergen or allergen extract, polysarcosine having an average molecular weight in the range of 2,000 to 12,000 and a chemical linking group connecting a reactive site on the polysarcosine to an amino group on the allergen or allergen extract, the reactive site on the polysarcosine being a H(CH 3 )N--, the allergen extract being an extract from an allergen selected from pollens, weeds, house dust mites and venoms, and the chemical linking group having the formula --CO--B--CO where B is a hydrocarbon chain of 1-4 carbon atoms. The disclosure also describes the analogous conjugates.
Inventors
- 👤 Andrew J. Garman
- 👤 Alan Wheeler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:05
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/35; Y; Y10; Y10S; Y10S424/00; Y10S424/805
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
62 words
A pharmaceutical composition for anti-allergy therapy comprising an anti-allergic amount of a material which comprises (1) an allergen or allergen extract, (2) polysarcosine of a number average molecular weight from 2,000 to 12,000, and (3) a chemical linking group linking a reactive site on the polysarcosine to an amino group on the allergen or allergen extract, together with a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
62 words
A pharmaceutical composition for anti-allergy therapy comprising an anti-allergic amount of a material which comprises (1) an allergen or allergen extract, (2) polysarcosine of a number average molecular weight from 2,000 to 12,000, and (3) a chemical linking group linking a reactive site on the polysarcosine to an amino group on the allergen or allergen extract, together with a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
19 words
A composition according to claim 1 wherein the reactive site on the polysarcosine is a H(CH 3 )N-- group.
Claim 4
Dependent Claim
29 words
A composition according to claim 1 wherein the allergen extract is an extract from an allergen selected from the group consisting of pollens, weeds, house dust mites and venoms.
Claim 5
Dependent Claim
27 words
A composition according to claim 1 wherein the chemical linking group is of formula --CO--B--CO where B is a hydrocarbon chain of 1 to 4 carbon atoms.
Claim 6
Dependent Claim
19 words
A composition according to claim 4 wherein B is --CH 2 --, --CH 2 --CH 2 --, or --CH═CH--.
Claim 7
Dependent Claim
16 words
A composition according to claim 1 wherein the chemical linking group is of the formula ##STR5##
Claim 8
Dependent Claim
22 words
A composition according to claim 1 wherein the polysarcosine has a number average molecular weight in the range of 3,000 to 9,000.
Claim 9
Dependent Claim
19 words
A composition according to claim 1 wherein from 4 to 40% of available amino groups are linked to polysarcosine.
Claim 10
Dependent Claim
11 words
A composition according to claim 1 which is a liquid vaccine.
Claim 11
Dependent Claim
14 words
A composition according to claim 1 which is a liquid spray or dry powder.
Claim 12
Dependent Claim
27 words
A method for the therapeutic treatment of allergic conditions which comprises administering to an allergy sufferer an anti-allergic effective amount of a composition according to claim 1.
Claim 13
Dependent Claim
63 words
An allergen-polysarcosine conjugate which comprises (1) an allergen or allergen extract (2) polysarcosine of a number average molecular weight from 2,000 to 12,000, (3) a chemical linking group of formula ##STR6## where B is a hydrocarbon chain of 1 to 4 carbon atoms, said linking group linking a reactive site on said polysarcosine to an amino grop on said allergen or allergen extract.
Claim 14
Dependent Claim
63 words
An allergen-polysarcosine conjugate which comprises (1) an allergen or allergen extract (2) polysarcosine of a number average molecular weight from 2,000 to 12,000, (3) a chemical linking group of formula ##STR6## where B is a hydrocarbon chain of 1 to 4 carbon atoms, said linking group linking a reactive site on said polysarcosine to an amino grop on said allergen or allergen extract.
Claim 15
Dependent Claim
18 words
A conjugate according to claim 12 wherein B is --CH 2 --, --CH 2 --CH 2 or --CH═CH--.
Claim 16
Dependent Claim
29 words
A conjugate according to claim 12 wherein the allergen extract is an extract from an allergen selected from the group consisting of pollens, weeds, house dust mites and venoms.
Claim 17
Dependent Claim
19 words
A conjugate according to claim 12 wherein the active site on the polysarcosine is a H(CH 3 )N-- group.
References Cited (Backward Citations)
US3619371A
Cited
US4152411A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-01 | 1990-03-03 | 1990-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-01 | 1994-03-03 | 1994-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-01 | 1998-03-03 | 1998-09-02 | $7700.00 | Window Closed / Lapsed |