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US4605652A
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Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
Assignee: AH Robins Co Inc
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Filing: 1985-02-04
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Granted: 1986-08-12
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Expires: 2005-02-04
Abstract
Abstract A pharmaceutical method for improving memory or correcting memory deficiency is disclosed, utilizing compounds having the formula: ##STR1## wherein n 1 , n 2 , n 3 , and n 4 =0 to 3; R 1 , R 2 , R 3 , and R 4 =H, loweralkyl or phenyl; R 5 =H or loweralkyl; X=O or S; Ar=phenyl, substituted phenyl, pyridinyl, furanyl, thienyl, methoxy-1H-benzotriazolyl, indolinyl, methoxyindolinyl, methoxypyrimidinyl, amino-methoxypyrimadinyl, 1,3-benzodioxolyl, or naphthalenyl, and the pharmaceutically acceptable acid addition salts, hydrates and alcoholates thereof.
Inventors
- 👤 William J. Welstead, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 19:01
CPC Classifications
C; C07; C07D; C07D453/00; C07D453/02; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/445; A61K31/495; A61P; A61P25/00; A61P25/28
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
131 words
A method for enhancing learning or memory in living animals in need thereof which comprises administering thereto an effective amount for enhancing learning or memory in said animal of a compound selected from the group having the formula: ##STR8## wherein n 1 , n 2 , n 3 , and n 4 are zero to three inclusive; R 1 , R 2 , R 3 , and R 4 are hydrogen, loweralkyl or phenyl; R 5 is hydrogen or loweralkyl; X is oxygen or sulfur; Ar is selected from ##STR9## Y is hydrogen, loweralkoxy, loweralkylthio, halo, trifluoromethyl, amino, loweralkylamino, diloweralkylamino, arylamino, acyl, aminosulfonyl, nitro, or aminocarbonyl; m is one to three inclusive; and a pharmaceutically acceptable acid addition salt and a hydrate and an alcoholate thereof and an optical isomer thereof.
Claim 2
Independent Claim
131 words
A method for enhancing learning or memory in living animals in need thereof which comprises administering thereto an effective amount for enhancing learning or memory in said animal of a compound selected from the group having the formula: ##STR8## wherein n 1 , n 2 , n 3 , and n 4 are zero to three inclusive; R 1 , R 2 , R 3 , and R 4 are hydrogen, loweralkyl or phenyl; R 5 is hydrogen or loweralkyl; X is oxygen or sulfur; Ar is selected from ##STR9## Y is hydrogen, loweralkoxy, loweralkylthio, halo, trifluoromethyl, amino, loweralkylamino, diloweralkylamino, arylamino, acyl, aminosulfonyl, nitro, or aminocarbonyl; m is one to three inclusive; and a pharmaceutically acceptable acid addition salt and a hydrate and an alcoholate thereof and an optical isomer thereof.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein the compound used is 4-amino-N-(azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxybenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 5
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-2-methoxybenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-2,4-dimethoxybenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-2-propoxybenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-3-methoxy-2-naphthalenecarboxamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 9
Dependent Claim
19 words
The method of claim 1 wherein the compound used is 4-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxythiobenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-4-nitrobenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Dependent Claim
19 words
The method of claim 1 wherein the compound used is 4-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 12
Dependent Claim
19 words
The method of claim 1 wherein the compound used is 5-aminosulfonyl-N-(1-azabicyclo[2.2.2]oct-3-yl-2-methoxybenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 13
Dependent Claim
19 words
The method of claim 1 wherein the compound used is 2-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 14
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 15
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-2-fluorobenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 16
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-2,6-dimethoxybenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 17
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-2-methoxy-5-(methylsulfonyl)benzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 18
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-5-bromo-2,4-dimethoxybenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 19
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-3-methoxybenzamide or a pharmaceutically acceptable acid addition salt thereof.
Claim 20
Dependent Claim
19 words
The method of claim 1 wherein the compound used is N-(1-azabicyclo[2.2.2]oct-3-yl)-3-fluorobenzamide or a pharmaceutically acceptable acid addition salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-11 | 1990-02-10 | 1990-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-11 | 1994-02-10 | 1994-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-11 | 1998-02-10 | 1998-08-12 | $7700.00 | Window Closed / Lapsed |