Patent US4605413A successfully refreshed from Google Patents.
US4605413A
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Stimulation of chemotaxis by chemotactic peptides
Assignee: UAB RESEARCH FOUNDATION NON-PROFIT CORP
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Filing: 1983-09-19
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Granted: 1986-08-12
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Expires: 2003-09-19
Abstract
Abstract A method of stimulating chemotaxis toward a prosthetic device is disclosed, which method comprises incorporating a chemotactic peptide of the formula B1-X-(APGVGV)n-Y-B2 wherein A is a peptide-forming residue of L-alanine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; B1 is H or a biocompatible N-terminal group; B2 is OH, OB3 where B3 is a non-toxic metal ion, or a biocompatible C-terminal group; X is PGVGV, GVGV, VGV, GV, V, or a covalent bond; Y is APGVG, APGV, APG, AP, A, or a covalent bond; and n is an integer from 1 to 100; into a surface of the prosthetic device. Prosthetic devices which have the property of enhancing invasion of elastic fiber synthesizing fibroblasts as a result of the chemotactic peptide are also disclosed.
Inventors
- 👤 Dan W. Urry
- 👤 Robert M. Senior
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:47
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/29
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
111 words
A prosthetic device wherein a surface of said device has a chemotactic peptide of the formula B.sup.1 --X--(APGVGV).sub.n --Y--B.sup.2 wherein A is a peptide-forming residue of L-alanine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; B 1 is H or a biocompatible N-terminal group; B 2 is OH, OB 3 where B 3 is a non-toxic metal ion, or a biocompatible C-terminal group; X is PGVGV, GVGV, VGV, GV, V, or a covalent bond; Y is APGVG, APGV, APG, AP, A, or a covalent bond; and n is an integer from 1 to 100; incorporated into said surface.
Claim 2
Dependent Claim
111 words
A prosthetic device wherein a surface of said device has a chemotactic peptide of the formula B.sup.1 --X--(APGVGV).sub.n --Y--B.sup.2 wherein A is a peptide-forming residue of L-alanine; P is a peptide-forming residue of L-proline; G is a peptide-forming residue of glycine; V is a peptide-forming residue of L-valine; B 1 is H or a biocompatible N-terminal group; B 2 is OH, OB 3 where B 3 is a non-toxic metal ion, or a biocompatible C-terminal group; X is PGVGV, GVGV, VGV, GV, V, or a covalent bond; Y is APGVG, APGV, APG, AP, A, or a covalent bond; and n is an integer from 1 to 100; incorporated into said surface.
Claim 3
Dependent Claim
12 words
The device of claim 12, wherein n is from 1 to 10.
Claim 4
Dependent Claim
10 words
The device of claim 1, wherein n is about 5.
Claim 5
Dependent Claim
9 words
The device of claim 1, wherein n is 1.
Claim 6
Dependent Claim
19 words
The device of claim 1, wherein said peptide is H--VGVAPG--OH, H--GVAPGV--OH, H--VAPGVG--OH, H--APGVGV--OH, H--PGVGVA--OH, H--GVGVAP--OH, or a salt thereof.
Claim 7
Dependent Claim
26 words
The device of claim 1, wherein B 1 is H and B 2 is OH or OB 3 where B 3 is an alkali metal ion.
Claim 8
Dependent Claim
28 words
The device of claim 1, wherein said amount is from 10 -9 to 10 -3 millimoles of hexamer or repeating unit per 100 cm 2 of said surface.
Claim 9
Dependent Claim
12 words
The device claim 1, wherein said prosthetic device comprises a structural polypeptide.
Claim 10
Dependent Claim
21 words
The device of claim 1, wherein said chemotactic peptide is incorporated using non-covalent bonding between said chemotactic peptide and said surface.
Claim 11
Dependent Claim
21 words
The device of claim 1, wherein said chemotactic peptide is incorporated using covalent bonding between said chemotactic peptide and said surface.
Claim 12
Dependent Claim
12 words
The device of claim 10, wherein said surface comprises a structural peptide.
References Cited (Backward Citations)
US4132746A
Cited
US4273873A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-11 | 1990-02-10 | 1990-08-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-11 | 1994-02-10 | 1994-08-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-11 | 1998-02-10 | 1998-08-12 | $7700.00 | Window Closed / Lapsed |