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US4604391A
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Treatment of osteitis and osteomyelitis employing thiadiazine compounds
Assignee: Ed Geistlich Soehne AG fuer Chemische Industrie
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Filing: 1984-10-19
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Granted: 1986-08-05
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Expires: 2004-10-19
Abstract
Abstract Compounds of formula (I) ##STR1## [wherein R 1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R 2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula (II) ##STR2## in which R 1 is as defined above] and pharmaceutical compositions thereof may be administered prophylactically to humans or warm-blooded animals to combat the occurrence of osteitis or osteomyelitis, especially in patients suffering from bone injuries of traumatic origin.
Inventors
- 👤 Rolf W. Pfirrmann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 12:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/54; A61P; A61P43/00; C; C07; C07D; C07D285/00; C07D285/15; C07D285/16; C07D285/18
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
91 words
A method of treating a human or warm-blooded animal patient suffering from bone injury to prevent the occurrence of osteitis or osteomyelitis, said method comprising administering systemically to said patient a therapeutically effective amount of a compound of formula (I) ##STR5## wherein R 1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R 2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula (II) ##STR6## in which R 1 is as defined above.
Claim 2
Independent Claim
91 words
A method of treating a human or warm-blooded animal patient suffering from bone injury to prevent the occurrence of osteitis or osteomyelitis, said method comprising administering systemically to said patient a therapeutically effective amount of a compound of formula (I) ##STR5## wherein R 1 represents a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms and R 2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms or a group of formula (II) ##STR6## in which R 1 is as defined above.
Claim 3
Dependent Claim
28 words
A method as claimed in claim 1 wherein there is administered to said patient a compound of formula (I) selected from the group consisting of taurolidine and taurultam.
Claim 4
Dependent Claim
19 words
A method as claimed in claim 1 wherein said compound of formula (I) is administered to said patient intravenously.
Claim 5
Dependent Claim
22 words
A method as claimed in claim 3 wherein from 10 to 40 g of said compound of formula (I) is administered daily.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-04 | 1990-02-03 | 1990-08-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-04 | 1994-02-03 | 1994-08-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-04 | 1998-02-03 | 1998-08-05 | $7700.00 | Window Closed / Lapsed |