US4603204A
Expired / Lapsed
US
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Theophylline derivatives
Assignee: Siegfried AG
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Filing: 1983-03-11
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Granted: 1986-07-29
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Expires: 2003-03-11
Abstract
Abstract New derivatives of theophylline having the formula ##STR1## in which R denotes hydrogen or OH, n the numbers 0 or 1, X either >CH-- or >N--, Y either --O-- or --CO-- and R a five membered or six membered aryl ring or hetero-aryl ring, that is substituted in given cases with halogen, short chain alkyl groups, alkoxy groups or halogen-alkyl, and exhibit in addition to other properties, histamine-, serotinine- bradykynine- antagonistic, anti-anaphylactic and -adrenergic stimulating effects.
Inventors
- 👤 Kurt Thiele
- 👤 Felix Geissmann
- 👤 Ludwig Zirngibl
- 👤 Ulrich Jahn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 05:47
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/08; A; A61; A61P; A61P25/00; A61P25/02; A61P29/00; A61P37/00; A61P37/08; A61P43/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
51 words
A theophylline derivative of the formula ##STR12## wherein R is hydrogen or a hydroxy group n is 0 or 1, Y is --O-- or ##STR13## and Ar is a phenyl, pyridyl, furyl, thienyl, pyrrolyl or imidazolyl ring which is unsubstituted or substituted with a methyl group, fluorine, chlorine, bromine, or trifluoromethyl.
Claim 2
Dependent Claim
51 words
A theophylline derivative of the formula ##STR12## wherein R is hydrogen or a hydroxy group n is 0 or 1, Y is --O-- or ##STR13## and Ar is a phenyl, pyridyl, furyl, thienyl, pyrrolyl or imidazolyl ring which is unsubstituted or substituted with a methyl group, fluorine, chlorine, bromine, or trifluoromethyl.
Claim 3
Dependent Claim
24 words
The compound of claim 1 wherein Ar is a furyl ring, or a phenyl ring which is substituted with a methyl group or fluorine.
Claim 4
Dependent Claim
8 words
The compound of claim 1 which is 7-(2-(4-(p-tolyloxy)piperidino)-ethyl)theophylline.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-28 | 1990-01-27 | 1990-07-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-28 | 1994-01-27 | 1994-07-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-28 | 1998-01-27 | 1998-07-29 | $7700.00 | Window Closed / Lapsed |