Patent US4602909A successfully refreshed from Google Patents.
US4602909A
Expired / Lapsed
US
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Iontophoresis intermediary material and contact solution for the treatment of chronic pain syndromes
Assignee: Richter Gedeon Vegyeszeti Gyar Nyrt
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Filing: 1983-02-07
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Granted: 1986-07-29
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Expires: 2003-02-07
Abstract
Abstract A method of treating chronic pain is disclosed which comprises the step of topically administering to the skin of a human patient, 1 to 100 mu g/cm2 of body surface of a compound of the Formula (I) <IMAGE> (I) in which R is -CH3 or -CHO R1 is methoxy or amino; R2 is hydrogen, hydroxyl or acetoxy; R3 is hydrogen or ethyl; R4 and R5 together form a valency bond or an epoxy bridge, or R4 is hydroxy or ethyl; and R5 is hydrogen; or a pharmaceutically acceptable acid addition salt thereof, by iontophoresis.
Inventors
- 👤 Bertalan Csillik
- 👤 Erzsebet Knyihar
- 👤 Attila Szucs
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:20
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/475; A61K9/00; A61K9/0002; A61K9/0009; A61P; A61P25/00; A61P25/02
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
103 words
A method of treating a chronic pain syndrome in a human, which comprises the step of topically administering to the skin of the human 1 to 100 μg/cm 2 of body surface of a compound of the Formula (I) ##STR3## in which R is --CH 3 or --CHO; R 1 is methoxy or amino; R 2 is hydrogen, hydroxyl or acetoxy; R 3 is hydrogen or ethyl; R 4 and R 5 together form a valency bond or an epoxy bridge, or R 4 is hydroxyl or ethyl; and R 5 is hydrogen; or a pharmaceutically acceptable acid addition salt thereof, by iontophoresis.
Claim 2
Independent Claim
103 words
A method of treating a chronic pain syndrome in a human, which comprises the step of topically administering to the skin of the human 1 to 100 μg/cm 2 of body surface of a compound of the Formula (I) ##STR3## in which R is --CH 3 or --CHO; R 1 is methoxy or amino; R 2 is hydrogen, hydroxyl or acetoxy; R 3 is hydrogen or ethyl; R 4 and R 5 together form a valency bond or an epoxy bridge, or R 4 is hydroxyl or ethyl; and R 5 is hydrogen; or a pharmaceutically acceptable acid addition salt thereof, by iontophoresis.
Claim 3
Dependent Claim
30 words
The method of treating a chronic pain syndrome defined in claim 1 wherein the compound of the Formula (I) is vinblastine in the form of its sulfate acid addition salt.
Claim 4
Dependent Claim
30 words
The method of treating a chronic pain syndrome defined in claim 1 wherein the compound of the Formula (I) is vincristine in the form of its sulfate acid addition salt.
Claim 5
Dependent Claim
20 words
The method of treating a chronic pain syndrome defined in claim 1 wherein the chronic pain syndrome is postherpetic neuralgia.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-28 | 1990-01-27 | 1990-07-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-28 | 1994-01-27 | 1994-07-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-28 | 1998-01-27 | 1998-07-29 | $7700.00 | Window Closed / Lapsed |