US4600526A
Expired / Lapsed
US
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Lipopeptides, their preparation and their application as emulsifiers
Assignee: Centre National de la Recherche Scientifique
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Filing: 1983-09-16
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Granted: 1986-07-15
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Expires: 2003-09-16
Abstract
Abstract The lipopeptides according to the invention are amphiphatic and consist of a hydrophobic chain containing from about 8 to 24 carbon atoms and of a peptide chain which is hydrophilic or has been rendered hydrophilic. They are applied, in particular, to emulsions of immiscible media and to the preparation of lyotropic liquid crystals.
Inventors
- 👤 Bernard Gallot
- 👤 Andre Douy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 07:49
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/02; A61K8/0295; A61K8/04; A61K8/06; A61K8/18; A61K8/30; A61K8/64; A61K8/72; A61K8/84; A61K8/88; A61Q; A61Q19/00; C; C07; C07K; C07K1/00; C07K1/107; C07K1/1072; C07K1/1077; C08; C08G; C08G69/00; C08G69/02; C08G69/08; C09; C09K; C09K19/00; C09K19/04; C09K19/38; C09K19/3833; C09K19/389; Y; Y10; Y10S; Y10S516/00; Y10S516/90
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
66 words
An amphiphatic lipopeptide of the formula CnSar.sub.p wherein Cn is a hydrophobic aliphatic amine having n carbon atoms, n is a whole number from 8 to 24, inclusive, Sar is a unit which has the structure of sarcosine linked through a peptide linkage to Cn or to another Sar, and p defines the degree of polymerization and is a positive whole number of at least one.
Claim 2
Dependent Claim
66 words
An amphiphatic lipopeptide of the formula CnSar.sub.p wherein Cn is a hydrophobic aliphatic amine having n carbon atoms, n is a whole number from 8 to 24, inclusive, Sar is a unit which has the structure of sarcosine linked through a peptide linkage to Cn or to another Sar, and p defines the degree of polymerization and is a positive whole number of at least one.
Claim 3
Dependent Claim
19 words
An emulsion of immiscible media, which contains at least about 1% of a lipopeptide as claimed in claim 1.
Claim 4
Dependent Claim
11 words
A lipopeptide as claimed in claim 1 having a lamellar structure.
Claim 5
Dependent Claim
11 words
A lipopeptide as claimed in claim 1 having a hexagonal structure.
Claim 6
Dependent Claim
12 words
A lipopeptide as claimed in claim 1 having a centered cubic structure.
Claim 7
Dependent Claim
12 words
The lipopeptide as claimed in claim 1 which is C17Sar 20 .
Claim 8
Dependent Claim
23 words
An amphiphatic lipopeptide CnSar p according to claim 26, wherein n is 16, 17 or 18 and p is 1, 2 or 3.
Claim 9
Dependent Claim
12 words
A lipopeptide as claimed in claim 7 which is C16Sar 1-3 .
Claim 10
Dependent Claim
12 words
A lipopeptide as claimed in claim 7 which is C17Sar 1-3 .
Claim 11
Dependent Claim
12 words
A lipopeptide as claimed in claim 7 which is C18Sar 1 .
Claim 12
Dependent Claim
12 words
A lipopeptide as claimed in claim 7 which is C18Sar 2 .
Claim 13
Dependent Claim
12 words
A lipopeptide as claimed in claim 7 which is C18Sar 3 .
Claim 14
Dependent Claim
38 words
A process of preparing a lyotropic liquid crystal which comprises dissolving in water a lipopeptide as claimed in claim 1 in an amount of at least about 60 percent and, optionally, evaporating water slowly from the resulting solution.
Claim 15
Dependent Claim
23 words
In emulification of immiscible liquids with an emulsifying agent, the improvement wherein the emulsifying agent is a lipopeptide as claimed in claim 1.
Claim 16
Dependent Claim
20 words
A liquid crystal the essential components of which are at least one lipopeptide as claimed in claim 1 and water.
References Cited (Backward Citations)
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Cited
US3064047A
Cited
JPS5266885A
Cited
US4310517A
Cited
US4301045A
Cited
US4299821A
Cited
US4308181A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-14 | 1990-01-13 | 1990-07-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-14 | 1994-01-13 | 1994-07-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-14 | 1998-01-13 | 1998-07-15 | $7700.00 | Window Closed / Lapsed |