US4308181A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polypeptide compositions
Assignee: Wyeth LLC
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Filing: 1980-12-08
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Granted: 1981-12-29
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Expires: 2000-12-08
Abstract
Abstract There are disclosed tetrapeptides having the formula: R.sub.1 -Ser-His-Leu-R.sub.2 wherein R 1 is N-lower alkanoyl or N-lower alkanoylGly; R 2 is NH 2 or Val-NH 2 ; the fully protected peptide-resin intermediates thereof and pharmaceutically acceptable salts thereof. These tetrapeptides have the capability of inducing the proliferation of T-cell populations and thus are useful in a number of therapeutic areas.
Inventors
- 👤 William H. McGregor
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 19:27
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; C07K5/1008; C07K5/1013; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/28
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
37 words
A tetrapeptide having the following formula: R.sub.1 -Ser-His-Leu-R.sub.2 wherein R 1 is N-lower alkanoyl or N-lower alkanoyGly; R 2 is NH 2 or Val-NH 2 ; the fully protected peptide-resin intermediates thereof, and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
37 words
A tetrapeptide having the following formula: R.sub.1 -Ser-His-Leu-R.sub.2 wherein R 1 is N-lower alkanoyl or N-lower alkanoyGly; R 2 is NH 2 or Val-NH 2 ; the fully protected peptide-resin intermediates thereof, and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
15 words
The compound of claim 1, which is acetyl-Gly-Ser-His-Leu-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
15 words
The compound of claim 1, which is acetyl-Ser-His-Leu-Val-NH 2 or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
38 words
A compound of the formula: ##STR2## wherein R 1 is N-lower alkanoyl or N-lower alkanoylGly; R 2 is NH 2 or Val-NH 2 ; A is a hydroxy protecting group; and B is an imidazole nitrogen protecting group.
Claim 6
Dependent Claim
38 words
A compound of the formula: ##STR2## wherein R 1 is N-lower alkanoyl or N-lower alkanoylGly; R 2 is NH 2 or Val-NH 2 ; A is a hydroxy protecting group; and B is an imidazole nitrogen protecting group.
Claim 7
Dependent Claim
17 words
The compound of claim 4, having the formula: ##STR3## wherein A is benzyl; and B is tosyl.
References Cited (Backward Citations)
US4171299A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-28 | 1985-06-29 | 1985-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-28 | 1989-06-29 | 1989-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-28 | 1993-06-29 | 1993-12-29 | $7700.00 | Window Closed / Lapsed |