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US4598094A
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Method and composition for enhancing the effect of indirect-acting sympathomimetic amines
Assignee: Massachusetts Institute of Technology
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Filing: 1985-09-25
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Granted: 1986-07-01
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Expires: 2005-09-25
Abstract
Abstract Tyrosine or a tyrosine precursor is administered concomitantly with an indirect-acting sympathomimetic amine drug to increase the level of norepinephrine that can be released in sympathetic neuron synapses.
Inventors
- 👤 Richard J. Wurtman
- 👤 Timothy J. Maher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 20:58
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
56 words
The process for preventing tachyphylaxis of amphetamine administered to a patient which comprises administering to said patient concomitantly with said amphetamine a catecholamine precursor selected from the group consisting of tyrosine, a tyrosine precursor or a mixture of tyrosine and a tyrosine precursor to obtain a tyrosine blood plasma concentration between about 15 and 100 μg/ml.
Claim 2
Dependent Claim
56 words
The process for preventing tachyphylaxis of amphetamine administered to a patient which comprises administering to said patient concomitantly with said amphetamine a catecholamine precursor selected from the group consisting of tyrosine, a tyrosine precursor or a mixture of tyrosine and a tyrosine precursor to obtain a tyrosine blood plasma concentration between about 15 and 100 μg/ml.
Claim 3
Dependent Claim
11 words
The process of claim 1 wherein said catecholamine precursor is tyrosine.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-30 | 1989-12-30 | 1990-07-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-30 | 1993-12-30 | 1994-07-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-30 | 1997-12-30 | 1998-07-01 | $7700.00 | Window Closed / Lapsed |