Patent US4597961A successfully refreshed from Google Patents.
US4597961A
Expired / Lapsed
US
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Transcutaneous application of nicotine
Assignee: New Mexico Tech Research Foundation
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Filing: 1985-01-23
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Granted: 1986-07-01
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Expires: 2005-01-23
Abstract
Abstract Percutaneous administration of nicotine in a dose approximating the dose delivered by a variety of nicotine-containing products, such as cigarettes, cigars, snuff and chewing tobacco, is carried out using an occlusive pad. The nicotine is delivered so as to mimic the pharmacological effects of nicotine provided by the conventional use of tobacco, and a therapeutic function is achieved by reducing or eliminating the need for the tobacco product. A suitable transdermal application pad comprises a reservoir for liquid nicotine base to be affixed to the skin in a variety of places. Due to the high lipid solubility and resultant high skin permeability of nicotine, vehicles or solvents are not generally needed to enhance dermal absorption.
Inventors
- 👤 Frank T. Etscorn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 04:19
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/465
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
85 words
A method of administering nicotine for the purpose of satisfying a nicotine habit while minimizing or eliminating side effects caused by absorbing nicotine through the lungs along with products of combustion of tobacco, comprising transdermally administering nicotine via an occlusive pad adhered to the skin at a dosage rate sufficient to satisfy said nicotine habit, said occlusive pad comprising a nicotine-impermeable backing and nicotine-permeable, porous, inert membrane, said nicotine impermeable backing and said nicotine-permeable membrane defining a cavity therebetween, said cavity containing liquid nicotine therein.
Claim 2
Independent Claim
85 words
A method of administering nicotine for the purpose of satisfying a nicotine habit while minimizing or eliminating side effects caused by absorbing nicotine through the lungs along with products of combustion of tobacco, comprising transdermally administering nicotine via an occlusive pad adhered to the skin at a dosage rate sufficient to satisfy said nicotine habit, said occlusive pad comprising a nicotine-impermeable backing and nicotine-permeable, porous, inert membrane, said nicotine impermeable backing and said nicotine-permeable membrane defining a cavity therebetween, said cavity containing liquid nicotine therein.
Claim 3
Dependent Claim
22 words
A method according to claim 1 wherein said nicotine is in the form of nicotine base without a solvent, vehicle or carrier.
Claim 4
Dependent Claim
35 words
A method according to claim 1 wherein said nicotine is in the form of nicotine base diluted with a pharmaceutically acceptable carrier, solvent or vehicle which reduces penetration of the nicotine base through the skin.
Claim 5
Dependent Claim
19 words
A method according to claim 1 wherein said nicotine is administered by application to the skin behind the ear.
Claim 6
Dependent Claim
15 words
A method according to claim 1 wherein said pad comprises 1-4 microliters of nicotine base.
Claim 7
Dependent Claim
23 words
A method according to claim 1 wherein said nicotine is transdermally administered at a dosage rate of 15-25 nanograms per liter of blood.
Claim 8
Dependent Claim
31 words
A method of administering nicotine for the purpose of satisfying a nicotine habit in accordance with claim 1, wherein said nicotine is transdermally administered to a patient physically addicted to nicotine.
Claim 9
Independent Claim
65 words
A method of assisting a person to quit smoking, comprising transdermally administering nicotine via an occlusive pad adhered to the skin at at a dosage rate approximately the same as provided when absorbing nicotine by smoking, said occlusive pad comprising a nicotine-impermeable backing and nicotine-permeable, porous, inert membrane, said nicotine-impermeable backing and said nicotine-permeable membrane defining a cavity therebetween, said cavity containing liquid nicotine therein.
Claim 10
Independent Claim
65 words
A method of assisting a person to quit smoking, comprising transdermally administering nicotine via an occlusive pad adhered to the skin at at a dosage rate approximately the same as provided when absorbing nicotine by smoking, said occlusive pad comprising a nicotine-impermeable backing and nicotine-permeable, porous, inert membrane, said nicotine-impermeable backing and said nicotine-permeable membrane defining a cavity therebetween, said cavity containing liquid nicotine therein.
Claim 11
Dependent Claim
31 words
A method according to claim 8 comprising carrying out a series of said transdermal administrations and interspercing said transdermal administrations with cigarettes to slowly extinguish the reinforcing properties of non-pharmacological factors.
Claim 12
Dependent Claim
15 words
A method according to claim 8 wherein said pad comprises 1-4 microliters of nicotine base.
Claim 13
Dependent Claim
22 words
A method according to claim 10 wherein said nicotine is in the form of nicotine base without a solvent, vehicle or carrier.
Claim 14
Dependent Claim
35 words
A method according to claim 10 wherein said nicotine is in the form of nicotine base diluted with a pharmaceutically acceptable carrier, solvent or vehicle which reduces penetration of the nicotine base through the skin.
Claim 15
Dependent Claim
19 words
A method according to claim 10 wherein said nicotine is administered by application to the skin behind the ear.
Claim 16
Dependent Claim
23 words
A method according to claim 8 wherein said nicotine is transdermally administered at a dosage level of 15-25 nanograms per liter of blood.
Claim 17
Dependent Claim
31 words
A method of administering nicotine for the purpose of satisfying a nicotine habit in accordance with claim 8, wherein said nicotine is transdermally administered to a patient physically addicted to nicotine.
Claim 18
Independent Claim
78 words
A method of administering nicotine for the purpose of satisfying a nicotine habit while minimizing or eliminating side effects caused by absorbing nicotine through the lungs along with products of combustion of tobacco, comprising transdermally administering nicotine via an occlusive pad adhered to the skin at a dosage rate sufficient to satisfy said nicotine habit, said occlusive pad comprising a nicotine impermeable backing defining a cavity therein, and an absorbant material having absorbed nicotine therein, within said cavity.
Claim 19
Independent Claim
78 words
A method of administering nicotine for the purpose of satisfying a nicotine habit while minimizing or eliminating side effects caused by absorbing nicotine through the lungs along with products of combustion of tobacco, comprising transdermally administering nicotine via an occlusive pad adhered to the skin at a dosage rate sufficient to satisfy said nicotine habit, said occlusive pad comprising a nicotine impermeable backing defining a cavity therein, and an absorbant material having absorbed nicotine therein, within said cavity.
Claim 20
Dependent Claim
15 words
A method according to claim 16 wherein said pad comprises 1-4 microliters of nicotine base.
Claim 21
Independent Claim
58 words
A method of assisting a person to quit smoking, comprising transdermally administering nicotine via an occlusive pad adhered to the skin at a dosage rate approximately the same as provided when absorbing nicotine by smoking, said occlusive pad comprising a nicotine impermeable backing defining a cavity therein, and an absorbant material having absorbed nicotine therein within said cavity.
Claim 22
Independent Claim
58 words
A method of assisting a person to quit smoking, comprising transdermally administering nicotine via an occlusive pad adhered to the skin at a dosage rate approximately the same as provided when absorbing nicotine by smoking, said occlusive pad comprising a nicotine impermeable backing defining a cavity therein, and an absorbant material having absorbed nicotine therein within said cavity.
Claim 23
Dependent Claim
15 words
A method according to claim 18 wherein said pad comprises 1-4 microliters of nicotine base.
References Cited (Backward Citations)
US1775998A
Cited
US3598122A
Cited
US3598123A
Cited
US3598122B1
Cited
US3731683A
Cited
US3742951A
Cited
US3742951B1
Cited
US3948254A
Cited
US4292299A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-30 | 1989-12-30 | 1990-07-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-30 | 1993-12-30 | 1994-07-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-30 | 1997-12-30 | 1998-07-01 | $7700.00 | Window Closed / Lapsed |