US4596804A
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Dibenz[b,e]oxepin compounds
Assignee: KH Neochem Co Ltd
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Filing: 1984-06-26
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Granted: 1986-06-24
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Expires: 2004-06-26
Abstract
Abstract A dibenz[b,e]oxepin compound having an antiallergic activity is represented by the following general formula: <IMAGE> wherein R1 represents a cyano group, a 5-tetrazolyl group, a carbamoyl group or -CO2R3 wherein R3 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or a 1-(ethoxycarbonyloxy)ethyl group, and R2 represents a 4-alkylpiperazino group wherein the alkyl group has 1 to 5 carbon atoms, a 3-quinuclidinylamino group or -X-(CH2)n-NR4R5 wherein X represents -NH-, -S - or -O-, R4 and R5 are same or different and each represents an alkyl group having 1 to 5 carbon atoms and n represents 2 or 3; and the pharmaceutically acceptable acid addition salts or metal salts thereof.
Inventors
- 👤 Hiroshi Takizawa
- 👤 Yoshimasa Oiji
- 👤 Kenji Ohmori
- 👤 Katsuichi Shuto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 17:40
CPC Classifications
C; C07; C07D; C07D405/00; C07D405/02; C07D405/04; A; A61; A61P; A61P37/00; A61P37/08; C07D313/00; C07D313/02; C07D313/06; C07D313/10; C07D313/12; C07D453/00; C07D453/02
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
120 words
A dibenz[b,e]oxepin compound of the formula (I): ##STR17## wherein R 1 represents a cyano group, a 5-tetrazolyl group, a carbamoyl group or --CO 2 R 3 wherein R 3 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or a 1-(ethoxycarbonyloxy)ethyl group, and R 2 represents a 4-alkylpiperazino group wherein the alkyl group has 1 to 5 carbon atoms, a 3-quinuclidinylamino group or --X--(CH 2 ) n --NR 4 R 5 wherein X represents --NH--, --S-- or --O--, R 4 and R 5 are same or different and each represents an alkyl group having 1 to 5 carbon atoms and n represents 2 or 3; and the pharmaceutically acceptable acid addition salts or metal salts thereof.
Claim 2
Dependent Claim
120 words
A dibenz[b,e]oxepin compound of the formula (I): ##STR17## wherein R 1 represents a cyano group, a 5-tetrazolyl group, a carbamoyl group or --CO 2 R 3 wherein R 3 represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or a 1-(ethoxycarbonyloxy)ethyl group, and R 2 represents a 4-alkylpiperazino group wherein the alkyl group has 1 to 5 carbon atoms, a 3-quinuclidinylamino group or --X--(CH 2 ) n --NR 4 R 5 wherein X represents --NH--, --S-- or --O--, R 4 and R 5 are same or different and each represents an alkyl group having 1 to 5 carbon atoms and n represents 2 or 3; and the pharmaceutically acceptable acid addition salts or metal salts thereof.
Claim 3
Dependent Claim
11 words
A compound of claim 1; namely, 11-(4-methylpiperazino)-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid dihydrochloride.1/4H 2 O.
Claim 4
Dependent Claim
10 words
A compound of claim 1; namely, 11-(N,N-dimethylaminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid ethyl ester.
Claim 5
Dependent Claim
11 words
A compound of claim 1; namely, 11-(N,N-dimethylaminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid hydrochloride.1/2H 2 O.
Claim 6
Dependent Claim
7 words
A compound of claim 1; namely, 11-(N,N-dimethylaminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-carbonitrile.
Claim 7
Dependent Claim
10 words
A compound of claim 1; namely, 11-(N,N-dimethylaminoethyl)oxy-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid ethyl ester.
Claim 8
Dependent Claim
7 words
A compound of claim 1; namely, 11-(N,N-dimethylaminoethyl)amino-6,11-dihydrodibenz[b,e]oxepin-2-carboamide.
Claim 9
Dependent Claim
10 words
A compound of claim 1; namely, 11-(3-quinuclidinyl)amino-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid ethyl ester.
Claim 10
Dependent Claim
10 words
A compound of claim 1; namely, 11-(4-methylpiperazino)-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid (1-ethoxycarbonyloxy)ethyl ester.
Claim 11
Dependent Claim
10 words
A compound of claim 1; namely, 11-(N,N-dimethylaminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid (1-ethoxycarbonyloxy)ethyl ester.
Claim 12
Dependent Claim
23 words
A pharmaceutical composition comprising a pharmaceutical carrier and, as an active ingredient, an effective amount of a dibenz[b,e]oxepin compound defined in claim 1.
Claim 13
Dependent Claim
17 words
A pharmaceutical composition according to claim 11, wherein said dibenz[b,e]oxepin compound is 11-(4-methylpiperazino)-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid dihydrochloride.1/4H 2 O.
Claim 14
Dependent Claim
16 words
A pharmaceutical composition according to claim 11, wherein said dibenz[b,e]oxepin compound is 11-(N,N-dimethylaminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid ethyl ester.
Claim 15
Dependent Claim
17 words
A pharmaceutical composition according to claim 11, wherein said dibenz[b,e]oxepin compound is 11-(N,N-dimethylaminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid hydrochloride.1/2H 2 O.
Claim 16
Dependent Claim
13 words
A pharmaceutical composition according to claim 11, wherein said dibenz[b,e]oxepin compound is 11-(N,N-dimethylaminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-carbonitrile.
Claim 17
Dependent Claim
16 words
A pharmaceutical composition according to claim 11, wherein said dibenz[b,e]oxepin compound is 11-(N,N-dimethylaminoethyl)oxy-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid ethyl ester.
Claim 18
Dependent Claim
13 words
A pharmaceutical composition according to claim 11, wherein said dibenz[b,e]oxepin compound is 11-(N,N-dimethylaminoethyl)amino-6,11-dihydrodibenz[b,e]oxepin-2-carboamide.
Claim 19
Dependent Claim
16 words
A pharmaceutical composition according to claim 11, wherein said dibenz[b,e]oxepin compound is 11-(3-quinuclidinyl)amino-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid ethyl ester.
Claim 20
Dependent Claim
16 words
A pharmaceutical composition according to claim 11, wherein said dibenz[b,e]oxepin compound is 11-(4-methylpiperazino)-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid (1-ethoxycarbonyloxy)ethyl ester.
Claim 21
Dependent Claim
16 words
A pharmaceutical composition according to claim 11, wherein said dibenz[b,e]oxepin compound is 11-(N,N-dimethylaminoethyl)thio-6,11-dihydrodibenz[b,e]oxepin-2-carboxylic acid (1-ethoxycarbonyloxy)ethyl ester.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-23 | 1989-12-23 | 1990-06-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-23 | 1993-12-23 | 1994-06-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-23 | 1997-12-23 | 1998-06-24 | $7700.00 | Window Closed / Lapsed |