US4596790A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Peptides for the treatment of hyperglycaemia
Assignee: REICHELT KARL LUDVIG
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Filing: 1984-10-18
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Granted: 1986-06-24
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Expires: 2004-10-18
Abstract
Abstract Peptides of formula I pGlu-X-Asp-Gly (I) (where X is Glu, Asp or Gln, and Gly, pGlu, Glu, Gln and Asp represent residues of glycine and L-forms of pyroglutamic acid, glutamic acid, glutamine and aspartic acid respectively) and/or physiologically acceptable salts thereof are disclosed together with a process for their preparation. The compounds may be used in the treatment of hyperglycaemia, and pharmaceutical compositions comprising as active ingredient at least one compound of formula I are also disclosed.
Inventors
- 👤 Olav E. Trygstad
- 👤 Karl-Ludwig Reichelt
- 👤 Kirsten Titlestad
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 13:36
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1024; A; A61; A61P; A61P3/00; A61P3/08; A61P5/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
42 words
A peptide of formula I pGlu-X-Asp-Gly (I) (where X is Glu, Asp or GLn, and Gly, pGlu, Glu, Gln and Asp represent residues of glycine and L-forms of pyroglutamic acid, glutamic acid, glutamine and aspartic acid respectively) and/or physiologically acceptable salts thereof.
Claim 2
Dependent Claim
42 words
A peptide of formula I pGlu-X-Asp-Gly (I) (where X is Glu, Asp or GLn, and Gly, pGlu, Glu, Gln and Asp represent residues of glycine and L-forms of pyroglutamic acid, glutamic acid, glutamine and aspartic acid respectively) and/or physiologically acceptable salts thereof.
Claim 3
Dependent Claim
10 words
A peptide as claimed in claim 1 in crystalline form.
Claim 4
Dependent Claim
44 words
Pharmaceutical compositions for the treatment of hyperglycaemia in warm-blooded animals comprising an effective amount of an active ingredient for treating hyperglycaemia, and wherein said active ingredient is at least one compound as defined in claim 1 in association with a pharmaceutical carrier or excipient.
Claim 5
Dependent Claim
20 words
Compositions as claimed in claim 3 containing 100 mg to 500 mg of a compound as claimed in claim 1.
Claim 6
Dependent Claim
38 words
A method of combatting hyperglycaemia in warm-blooded animals including humans which comprises administering an effective amount of a pharmaceutical composition as defined in claim 3 to a subject suffering from hyperglycaemia whereby extra cellular glucose levels are reduced.
Claim 7
Dependent Claim
14 words
A pharmaceutical composition as claimed in claim 3, wherein the warm-blooded animals are humans.
Claim 8
Dependent Claim
16 words
A method of combatting hyperglycaemia as claimed in claim 5 wherein the warm-blooded animals are humans.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-23 | 1989-12-23 | 1990-06-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-23 | 1993-12-23 | 1994-06-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-23 | 1997-12-23 | 1998-06-24 | $7700.00 | Window Closed / Lapsed |