Liquid delivery system particularly useful as an implantable micropump for delivering insulin or other drugs

Claim 2

A liquid delivery system comprising: a collapsible reservoir for a feed liquid to be delivered; a first rigid housing enclosing said collapsible reservoir; a collapsible container for a drive liquid; a second rigid housing enclosing said collapsible container for the drive liquid; a refill container; and pumping means for selectively pumping said drive liquid either from the drive liquid container into said first rigid housing between its inner face and the collapsible reservoir for pumping the feed liquid therefrom, or out of said first rigid housing into the drive liquid container for refilling said collapsible reservoir with feed liquid from said refill container; the interior of said second rigid housing being maintained under sub-ambient pressure so that in the event of malfunction of the pumping means, said sub-ambient pressure tends to draw the drive liquid into its collapsible container, and thereby provides fail-safe protection against the pumping out of the feed liquid from its reservoir.

Claim 3

The system according to claim 1, wherein said refill container is selectively connectible to said feed liquid reservoir for refilling same.

Claim 4

The system according to claim 2, further including means, effective upon connection of said refill container to the inlet of the feed liquid reservoir, for automatically actuating said pumping means to pump the drive liquid into its container, and thereby to cause the supply of feed liquid to be drawn into its reservoir from the refill container.

Claim 5

The system according to claim 3, wherein said pumping means are electrically energized and are controlled by a control system including an electrical switch actuated upon the connection of said refill container to the inlet of the feed liquid reservoir.

Claim 6

The system according to claim 4, wherein all of said recited elements, except for said refill container, are incorporated within a self-contained unit implantable into a living body.

Claim 7

The system according to claim 4, wherein said inlet is normally sealed closed, said refill container including an outlet tube adapted to penetrate said seal and at the same time to actuate said electric switch.

Claim 8

The system according to claim 4, wherein said control system includes a memory which continuously stores a value representing the quantity of feed liquid delivered by said pumping means, said pumping means being actuated by said electrical switch to cause a quantity of feed liquid to be drawn into its collapsible reservoir from the refill container corresponding to said stored quantity of feed liquid previously delivered by said pumping means, and thereupon to automatically terminate the operation of the pumping means.

Claim 9

The system according to claim 1, wherein said pumping means comprises: a chamber having at least one wall including a membrane deflectable to expand and contract said chamber and thereby to pump the feed liquid; a drive for deflecting said membrane to expand and contract said chamber; and a sensor sensing the deflections of said membrane to provide a measurement of the quantity of feed liquid pumped by said pumping chamber.

Claim 10

A liquid delivery system, comprising: a pumping chamber having at least one wall including a membrane deflectable to expand and contract said chamber and thereby to pump a liquid therefrom; a drive for deflecting said membrane to expand and contract said chamber; and a sensor sensing the deflections of said membrane to provide a measurement of the quantity of the liquid pumped by the pumping chamber.

Claim 11

A liquid delivery system, comprising: a pumping chamber having at least one wall including a membrane deflectable to expand and contract said chamber and thereby to pump a liquid therefrom; a drive for deflecting said membrane to expand and contract said chamber; and a sensor sensing the deflections of said membrane to provide a measurement of the quantity of the liquid pumped by the pumping chamber.

Claim 12

The system according to claim 9, wherein said deflectable membrane includes a piezoelectric wafer.

Claim 13

The system according to claim 10, wherein said piezoelectric wafer includes a driving electrode for driving the wafer, and a sensing electrode for sensing the magnitude and frequency of the deflections of the wafer.

Claim 14

A liquid delivery system comprising a feed liquid reservoir for a feed liquid to be delivered; a refill container for containing a supply of refill feed liquid, which refill container is selectively connectable to the feed liquid reservoir for refilling same; pumping means for selectively pumping the feed liquid either out from its reservoir for delivering same to another location, or into its reservoir from the refill container for refillling same; and a control system for controlling said pumping means; said control system including a memory which continuously stores a value representing the quantity of feed liquid delivered by said pumping means from said feed liquid reservoir; and control means, effective upon the connection of said refill container to the inlet of the feed liquid reservoir, for automatically operating said pumping means to cause a quantity of feed liquid to be drawn into the feed liquid reservoir from the refill container corresponding to the stored quantity of feed liquid previously delivered by said pumping means, and thereupon to automatically terminate the operation of the pumping means.

Claim 15

A liquid delivery system comprising a feed liquid reservoir for a feed liquid to be delivered; a refill container for containing a supply of refill feed liquid, which refill container is selectively connectable to the feed liquid reservoir for refilling same; pumping means for selectively pumping the feed liquid either out from its reservoir for delivering same to another location, or into its reservoir from the refill container for refillling same; and a control system for controlling said pumping means; said control system including a memory which continuously stores a value representing the quantity of feed liquid delivered by said pumping means from said feed liquid reservoir; and control means, effective upon the connection of said refill container to the inlet of the feed liquid reservoir, for automatically operating said pumping means to cause a quantity of feed liquid to be drawn into the feed liquid reservoir from the refill container corresponding to the stored quantity of feed liquid previously delivered by said pumping means, and thereupon to automatically terminate the operation of the pumping means.

Claim 16

The system according to claim 12, wherein said pumping means are electrically energized, and said control means includes an electrical switch which is automatically actuated upon the connection of said refill container to the inlet of the feed liquid reservoir.

Claim 17

The system according to claim 13, wherein the inlet of the feed liquid reservoir is normally sealed closed, said refill container including an outlet tube adapted to penetrate said seal and at the same time to actuate said electric switch.

Claim 18

The system according to claim 12, wherein said feed liquid reservoir is collapsible and is enclosed within a rigid housing, said system further including a container for a drive liquid which is pumped by said pumping means into said rigid housing between its inner face and the outer face of said collapsible reservoir for the feed liquid.

Claim 19

The system according to claim 15, wherein said drive liquid container is also collapsible, and is also disposed within a rigid housing; the space in said latter rigid housing being maintained under sub-ambient pressure, such that in the event of malfunction of the pump means, the sub-ambient pressure tends to draw the drive liquid into its collapsible reservoir, and thereby provides fail-safe protection against the pumping out of feed liquid from its collapsible reservoir.

Claim 20

The system according to claim 15, wherein said collapsible reservoir for the feed liquid including its rigid housing, the drive liquid container, and the pumping means including its control system, are all incorporated in a self-contained unit implantable in a living body.

Claim 21

The system according to claim 15, wherein said feed liquid reservoir is in a feed liquid unit which also includes a drive chamber separated from the feed liquid reservoir by a displaceable separator wall; said pumping means including an expansible and contractable pumping chamber; a first valve connecting said drive chamber to one end of said pumping chamber; a second valve connecting the opposite end of said pumping chamber to the drive liquid container; drive means for expanding and contracting said pumping chamber; and means for selectively controlling said first and second valves so as either to cause the pumping chamber to pump the drive liquid from said drive liquid container into said drive chamber of the feed liquid unit and thereby to deliver feed liquid from said feed liquid reservoir, or to pump the drive liquid from said drive chamber of the feed liquid unit to the drive liquid container and thereby to draw refill feed liquid into said feed liquid reservoir.

Claim 22

The system according to claim 18, wherein a wall of said expansible and contractible chamber includes a piezoelectric wafer driven under the control of said control means.

Claim 23

The system according to claim 18, wherein said first valve connects said drive liquid container directly to one end of said pumping chamber, and said second valve connects the opposite end of said pumping chamber to said drive chamber of the feed liquid unit.

Claim 24

A liquid delivery system, comprising: a feed liquid unit including a feed liquid reservoir, and a drive chamber separated therefrom by a displaceable separator wall; a drive liquid unit including a drive liquid reservoir; an expansible and contractable pumping chamber; a first valve connecting said drive chamber of the feed liquid unit to one end of said pumping chamber; a second valve connecting the opposite end of said pumping chamber to the drive liquid reservoir of the drive liquid unit; drive means for expanding and contracting said pumping chamber; a refill container connectible to said feed liquid reservoir for refilling it; and means for selectively controlling said first and second valves so as either to cause the pumping chamber to pump the drive liquid from said drive liquid reservoir into said drive chamber of the feed liquid unit and thereby to deliver feed liquid from said feed liquid reservoir, or to pump the drive liquid from said drive chamber of the feed liquid unit to the drive liquid reservoir and thereby to draw refill feed liquid from said refill container into said feed liquid reservoir; said feed liquid reservoir being collapsible and being enclosed within a first rigid housing, and said drive liquid reservoir being also collapsible and also enclosed within a second rigid housing; the interior of said second rigid housing being maintained under sub-ambient pressure such that in the event of malfunction, the sub-ambient pressure in said second rigid housing tends to draw the drive liquid into its collapsible reservoir, and thereby prevents pumping out the feed liquid from its reservoir malfunction.

Claim 25

A liquid delivery system, comprising: a feed liquid unit including a feed liquid reservoir, and a drive chamber separated therefrom by a displaceable separator wall; a drive liquid unit including a drive liquid reservoir; an expansible and contractable pumping chamber; a first valve connecting said drive chamber of the feed liquid unit to one end of said pumping chamber; a second valve connecting the opposite end of said pumping chamber to the drive liquid reservoir of the drive liquid unit; drive means for expanding and contracting said pumping chamber; a refill container connectible to said feed liquid reservoir for refilling it; and means for selectively controlling said first and second valves so as either to cause the pumping chamber to pump the drive liquid from said drive liquid reservoir into said drive chamber of the feed liquid unit and thereby to deliver feed liquid from said feed liquid reservoir, or to pump the drive liquid from said drive chamber of the feed liquid unit to the drive liquid reservoir and thereby to draw refill feed liquid from said refill container into said feed liquid reservoir; said feed liquid reservoir being collapsible and being enclosed within a first rigid housing, and said drive liquid reservoir being also collapsible and also enclosed within a second rigid housing; the interior of said second rigid housing being maintained under sub-ambient pressure such that in the event of malfunction, the sub-ambient pressure in said second rigid housing tends to draw the drive liquid into its collapsible reservoir, and thereby prevents pumping out the feed liquid from its reservoir malfunction.

Claim 26

The system according to claim 21, wherein a wall of said pumping chamber includes a piezoelectric wafer driven to expand and contract said chamber.

Claim 27

The system according to claim 21, further including means, effective upon connection of the refill container to the feed liquid reservoir, for automatically actuating the drive to expand and contract said pumping chamber with said first and second valves controlled so as to cause feed liquid to be drawn from the refill container into the feed liquid reservoir.

Claim 28

The system according to claim 23, wherein said drive is controlled by a control system which includes a memory continuously storing the quantity of feed liquid delivered by the system, said drive being automatically actuated upon the insertion of the refill container to cause a quantity of feed liquid to be drawn into its feed liquid reservoir corresponding to the quantity stored in said memory as previously delivered by the system, and thereupon to be automatically terminated.

Claim 29

The system according to claim 21, wherein all the recited elements of the system, except for the refill container, are incorporated in a self-contained unit implantable in a living body.