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US4594450A
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Process for producing an α-halogeno-β-phenylpropionic acid
Assignee: Tosoh Corp
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Filing: 1984-10-12
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Granted: 1986-06-10
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Expires: 2004-10-12
Abstract
Abstract A process for producing an α-halogeno-β-phenylpropionic acid represented by the general formula: ##STR1## where X is a halogen atom, which comprises hydrolyzing under heating a halogen-containing ethylbenzene derivative represented by the general formula: ##STR2## where W is a cyano group, an amidocarbonyl group or a lower alkoxycarbonyl group, and X is as defined above, in an aqueous mineral acid solution under vigorous stirring.
Inventors
- 👤 Kiyotaka Oyama
- 👤 Tuneo Harada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 16:41
CPC Classifications
C; C07; C07C; C07C51/00; C07C51/08; C07C51/06; C07C51/09
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
82 words
In a process for producing an α-halogeno-β-phenyl-propionic acid represented by the formula (I): ##STR5## where X is a halogen atom, which comprises hydrolyzing under heating a halogen-containing ethylbenzene derivative represented by the formula (II): ##STR6## where W is a cyano group, an amidocarbonyl group or a lower alkoxycarbonyl group, and X is as defined above, and an aqueous mineral acid solution under vigorous stirring, the improvement which comprises conducting said reaction in a two-phase system in the absence of an organic acid.
Claim 2
Dependent Claim
82 words
In a process for producing an α-halogeno-β-phenyl-propionic acid represented by the formula (I): ##STR5## where X is a halogen atom, which comprises hydrolyzing under heating a halogen-containing ethylbenzene derivative represented by the formula (II): ##STR6## where W is a cyano group, an amidocarbonyl group or a lower alkoxycarbonyl group, and X is as defined above, and an aqueous mineral acid solution under vigorous stirring, the improvement which comprises conducting said reaction in a two-phase system in the absence of an organic acid.
Claim 3
Dependent Claim
32 words
The process according to claim 1, wherein the stirring is sufficiently vigorous to form and maintain an emulsion of the halogen-containing ethylbenzene derivative and the aqueous mineral acid solution during the hydrolysis.
Claim 4
Dependent Claim
24 words
The process according to claim 1, wherein the mineral acid in the aqueous mineral acid solution is hydrochloric acid, hydrobromic acid or sulfuric acid.
Claim 5
Dependent Claim
33 words
The process according to claim 1, wherein the amount of the mineral acid in the aqueous mineral acid solution is at least 3 mols relative to 1 mol of the halogencontaining ethylbenzene derivative.
Claim 6
Dependent Claim
26 words
The process according to claim 1, wherein the amount of the water in the aqueous mineral acid solution is at least two times the stoichiometric amount.
Claim 7
Dependent Claim
26 words
The process according to claim 1, wherein the concentration of the mineral acid in the aqueous mineral acid solution is at least about 15% by weight.
Claim 8
Dependent Claim
20 words
The process according to claim 1, wherein the reaction is conducted at a temperature of at least about 50° C.
References Cited (Backward Citations)
JPS6158732A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-09 | 1989-12-09 | 1990-06-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-09 | 1993-12-09 | 1994-06-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-09 | 1997-12-09 | 1998-06-10 | $7700.00 | Window Closed / Lapsed |