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US4594247A
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Synergistic antibacterial compositions and method of treatment of infections caused by multiple antibiotic-resistant organisms
Assignee: Eli Lilly and Co
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Filing: 1984-01-27
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Granted: 1986-06-10
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Expires: 2004-01-27
Abstract
Abstract Antibiotic compositions comprising a 1-oxa β-lactam antibiotic compound of the formula ##STR1## or pharmaceutically acceptable salts thereof and either tobramycin, amikacin or piperacillin exhibit synergistic activity against multiple-antibiotic-resistant organisms. The 1-oxa compound can be used in conjunction with tobramycin, amikacin or piperacillin in a method of treating infections caused by resistant organisms.
Inventors
- 👤 Gordon L. Brier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 15:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/535
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
37 words
A synergistic antibacterial composition comprising 1 part by weight, as the diacid, of a compound of the formula ##STR3## or a pharmaceutically acceptable salt thereof, and from about 0.1 to about 16 parts by weight of piperacillin.
Claim 2
Dependent Claim
37 words
A synergistic antibacterial composition comprising 1 part by weight, as the diacid, of a compound of the formula ##STR3## or a pharmaceutically acceptable salt thereof, and from about 0.1 to about 16 parts by weight of piperacillin.
Claim 3
Dependent Claim
30 words
A method of treating infections caused by multiple-antibiotic-resistant gram-negative organisms in a warm-blooded animal which comprises administering to said animal an antibacterially effective amount of the composition of claim 1.
References Cited (Backward Citations)
US4087424A
Cited
US4138486A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-09 | 1989-12-09 | 1990-06-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-09 | 1993-12-09 | 1994-06-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-09 | 1997-12-09 | 1998-06-10 | $7700.00 | Window Closed / Lapsed |