US4588746A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Propylamine derivatives
Assignee: Novartis Corp
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Filing: 1984-01-04
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Granted: 1986-05-13
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Expires: 2004-01-04
Abstract
Abstract Disclosed are e.g. certain novel 2-benzyl-3-(substituted)-phenoxypropylamines, their methods of synthesis and pharmaceutical compositions. Said compounds are useful as potent and centrally active serotonin uptake inhibitors for the treatment of psychotropic disorders, particularly depression.
Inventors
- 👤 Jeffrey W. H. Watthey
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 11:46
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/092; C07C; C07C227/00; C07C227/04; C07C227/06; C07C227/08; C07C227/14; C07C227/16
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
31 words
A compound having the formula ##STR19## wherein R 1 represents hydrogen or methyl; R 2 represents methyl; R 3 represents hydrogen; and Ar represents 4-trifluoromethylphenyl; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
31 words
A compound having the formula ##STR19## wherein R 1 represents hydrogen or methyl; R 2 represents methyl; R 3 represents hydrogen; and Ar represents 4-trifluoromethylphenyl; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
15 words
A compound of claim 1 being N,N-dimethyl-2-benzyl-3-(4-trifluoromethylphenoxy)propylamine or a pharmaceutically acceptable acid addition salt thereof.
Claim 4
Dependent Claim
13 words
A compound of claim 1 being N-methyl-2-benzyl-3-(4-trifluoromethylphenoxy)propylamine or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
25 words
An antidepressant pharmaceutical composition comprising an effective amount of a serotonin uptake inhibiting compound of claim 1 in combination with one or more pharmaceutical carriers.
Claim 6
Dependent Claim
18 words
A pharmaceutical composition according to claim 4 wherein the compound is N-methyl-2-benzyl-3-(4-trifluoromethylphenoxy)propylamine or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
37 words
A method of treating mammals suffering from depression which comprises administering to said mammal in need thereof an effective amount of a serotonin uptake inhibiting compound of claim 1 in combination with one or more pharmaceutical carriers.
Claim 8
Dependent Claim
17 words
A method according to claim 6 wherein the compound is N-methyl-2-benzyl-3-(4-trifluoromethylphenoxy)-propylamine or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-12 | 1989-11-11 | 1990-05-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-12 | 1993-11-11 | 1994-05-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-12 | 1997-11-11 | 1998-05-13 | $7700.00 | Window Closed / Lapsed |