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US4585785A
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Cis and trans-3-aryloxy-4-hydroxypyrrolidines used as anti-arrhythmics
Assignee: Wyeth LLC
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Filing: 1980-03-10
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Granted: 1986-04-29
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Expires: 2000-03-10
Abstract
Abstract Cis and trans-3-aryloxy-4-hydroxypyrrolidines and derivatives thereof having the formula: ##STR1## are disclosed wherein R 1 is hydrogen, loweralkyl, benzyloxycarbonyl and N-loweralkylcarbamoyl; R 2 is hydrogen, lower alkyl, cycloalkyl, phenylalkyl, benzyloxycarbonyl, carbamoyl, N-loweralkylcarbamoyl, N-diloweralkylcarbamoyl and parafluorobenzoyl-lower-alkyl; Ar is phenyl, substituted phenyl, 1-naphthyl, 2-naphthyl, 1-indenyl and 2-indenyl and pharmaceutically acceptable acid addition and quaternary salts thereof. The compounds have antidepressant, antihypertensive and antiarrythmic activity in animals.
Inventors
- 👤 David A. Walsh
- 👤 William J. Welstead, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 06:34
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/04; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/12; C07D207/18; C07D207/20
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
55 words
A method of treating arrhythmias in animals which comprises administering to said animal an effective amount of a compound selected from 3-aryloxy-4-hydroxypyrrolidines having the formula: ##STR10## wherein R 2 is hydrogen or lower alkyl, Ar is selected from the group consisting of 1-naphthyl, 2-naphthyl, 4-indanyl, and 5-indanyl and the pharmaceutically acceptable acid addition salts thereof.
Claim 2
Independent Claim
55 words
A method of treating arrhythmias in animals which comprises administering to said animal an effective amount of a compound selected from 3-aryloxy-4-hydroxypyrrolidines having the formula: ##STR10## wherein R 2 is hydrogen or lower alkyl, Ar is selected from the group consisting of 1-naphthyl, 2-naphthyl, 4-indanyl, and 5-indanyl and the pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
10 words
The method of claim 1 wherein the compound is trans-1-ethyl-4-(1-naphthaleneyloxy)-3-pyrrolidinol.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein said 3-aryloxy-4-hydroxypyrrolidines and derivatives thereof are the trans isomers.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-28 | 1989-10-28 | 1990-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-28 | 1993-10-28 | 1994-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-28 | 1997-10-28 | 1998-04-29 | $7700.00 | Window Closed / Lapsed |