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US4585783A
Expired / Lapsed
US
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Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
Assignee: Richardson Vicks Inc
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Filing: 1985-03-14
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Granted: 1986-04-29
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Expires: 2005-03-14
Abstract
Abstract Novel pharmaceutical compositions of matter are provided comprising analgesic/non-steroidal anti-inflammatory drugs and diphenhydramine and methods of using said compositions to elicit an enhanced analgesic and/or anti-inflammatory response in mammalian organisms in need of such treatment.
Inventors
- 👤 Abraham Sunshine
- 👤 Eugene M. Laska
- 👤 Carole E. Siegel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 17:24
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/33; A61K31/395; A61K31/40
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
51 words
A method for eliciting an enhanced analgesic and anti-inflammatory response in a mammalian organism in need of such treatment, comprising administering to such organism (i) an analgesically and anti-inflammatorily effective amount of tolmetin or indomethacin or a pharmaceutically acceptable salt thereof, and (ii) an analgesically and anti-inflammatorily potentiating amount of diphenhydramine.
Claim 2
Independent Claim
51 words
A method for eliciting an enhanced analgesic and anti-inflammatory response in a mammalian organism in need of such treatment, comprising administering to such organism (i) an analgesically and anti-inflammatorily effective amount of tolmetin or indomethacin or a pharmaceutically acceptable salt thereof, and (ii) an analgesically and anti-inflammatorily potentiating amount of diphenhydramine.
Claim 3
Dependent Claim
20 words
A method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of tolmetin.
Claim 4
Dependent Claim
20 words
A method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of indomethacin.
Claim 5
Dependent Claim
16 words
A method as defined by claim 1, comprising from about 25 mg to 200 mg tolmetin.
Claim 6
Dependent Claim
16 words
A method as defined by claim 1, comprising from about 25 mg to 200 mg indomethacin.
Claim 7
Dependent Claim
16 words
A method as defined by claim 1, comprising from about 12.5 mg to 50 mg diphenhydramine.
Claim 8
Dependent Claim
16 words
A method as defined by claim 6, comprising from about 25 mg to 50 mg diphenhydramine.
Claim 9
Dependent Claim
13 words
A method as defined by claim 1, wherein said composition is administered orally.
Claim 10
Dependent Claim
34 words
A method as defined by claim 8, wherein said composition is administered daily in divided doses comprising from about 25 mg to 200 mg tolmetin and from about 25 mg to 50 mg diphenylhydramine.
Claim 11
Dependent Claim
34 words
A method as defined by claim 8, wherein said composition is administered daily in divided doses comprising from about 25 mg to 200 mg indomethacin and from about 25 mg to 50 mg diphenhydramine.
Claim 12
Dependent Claim
24 words
A method as defined by claim 1, wherein said composition is administered orally at bedtime as an analgesically and anti-inflammatorily effective nighttime sleep aid.
Claim 13
Dependent Claim
47 words
A pharmaceutical composition of matter for eliciting an enhanced analgesic and anti-inflammatory response in a mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatorily effective amount of tolmetin or indomethacin or a pharmaceutically acceptable salt thereof; and (ii) an analgesically and anti-inflammatorily potentiating amount of diphenhydramine.
Claim 14
Dependent Claim
47 words
A pharmaceutical composition of matter for eliciting an enhanced analgesic and anti-inflammatory response in a mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatorily effective amount of tolmetin or indomethacin or a pharmaceutically acceptable salt thereof; and (ii) an analgesically and anti-inflammatorily potentiating amount of diphenhydramine.
Claim 15
Dependent Claim
23 words
A pharmaceutical composition of matter as defined by claim 12, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of tolmetin.
Claim 16
Dependent Claim
22 words
The composition of matter as defined in claim 12, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of indomethacin.
Claim 17
Dependent Claim
17 words
The composition of matter as defined by claim 12, further comprising a non-toxic pharmaceutically acceptable inert carrier.
Claim 18
Dependent Claim
18 words
A composition of matter as defined by claim 12, comprising from about 25 mg to 200 mg tolmetin.
Claim 19
Dependent Claim
18 words
A composition of matter as defined by claim 12, comprising from about 25 mg to 200 mg indomethacin.
Claim 20
Dependent Claim
18 words
A composition of matter as defined by claim 12, comprising from about 12.5 mg to 50 mg diphenhydramine.
Claim 21
Dependent Claim
20 words
A composition of matter as defined by claim 12, wherein said diphenylhydramine is present as the pharmaceutically acceptable salt thereof.
Claim 22
Dependent Claim
27 words
A composition of matter as defined by claim 12, comprising from about 25 mg to 200 mg tolmetin and from about 25 mg to 50 mg diphenhydramine.
Claim 23
Dependent Claim
27 words
A composition of matter as defined by claim 12, comprising from about 25 mg to 200 mg indomethacin and from about 25 mg to 50 mg diphenhydramine.
Claim 24
Dependent Claim
16 words
A composition of matter as defined by claim 12, said composition being adapted for oral administration.
Claim 25
Dependent Claim
19 words
A composition of matter as defined by claim 22, said composition being formulated as a tablet, capsule or elixir.
Claim 26
Dependent Claim
20 words
A composition of matter as defined by claim 22, said composition being adapted for oral administration in sustained release form.
Claim 27
Dependent Claim
16 words
A composition of matter as defined by claim 12, said composition being adapted for parenteral administration.
Claim 28
Dependent Claim
16 words
A composition of matter as defined by claim 25, said composition being formulated for intramuscular administration.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-28 | 1989-10-28 | 1990-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-28 | 1993-10-28 | 1994-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-28 | 1997-10-28 | 1998-04-29 | $7700.00 | Window Closed / Lapsed |