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US4585654A
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Process for pasteurizing fibronectin
Assignee: AMOUR PHARMACEUTICAL Co
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Filing: 1984-12-21
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Granted: 1986-04-29
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Expires: 2004-12-21
Abstract
Abstract A process for heating and simultaneously agitating a plasma protein solution in the presence of a polyol, a surface active agent and a chelating agent. Said process inactivates viruses in said solution while preserving the physical and biological properties of said plasma protein.
Inventors
- 👤 Ricardo H. Landaburu
- 👤 Godfrey W. Amphlett
- 👤 Roy E. Branson
- 👤 Arthur B. Shaw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:15
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61L2/04; A61L2103/00; A61L2103/05
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
117 words
A process for pasteurizing an aqueous solution consisting essentially of fibronectin to inactivate hepatitis viruses therein while preserving its native character consisting essentially of: heating and simultaneously mechanically agitating said aqueous solution containing fibronectin at 60° to 70° C. for 10 to 20 hours to effect pasteurization thereof in the presence of: 25% to 50% w/v of a polyol selected from the group consisting of sucrose, maltose, lactose, glucose, mannose, and galactose; 0.01% to 0.5% w/v of a surface active agent selected from the group consisting of sodium cholate, sodium taurocholate, sodium deoxycholate, and sodium glycocholate; and 0.0005 to 0.2M of a chelating agent selected from the group consisting of ethylenediaminetetraacetic acid, ethylene-bis-(oxyethylene nitrile)tetraacetic acid and orthophenanthrolene.
Claim 2
Dependent Claim
117 words
A process for pasteurizing an aqueous solution consisting essentially of fibronectin to inactivate hepatitis viruses therein while preserving its native character consisting essentially of: heating and simultaneously mechanically agitating said aqueous solution containing fibronectin at 60° to 70° C. for 10 to 20 hours to effect pasteurization thereof in the presence of: 25% to 50% w/v of a polyol selected from the group consisting of sucrose, maltose, lactose, glucose, mannose, and galactose; 0.01% to 0.5% w/v of a surface active agent selected from the group consisting of sodium cholate, sodium taurocholate, sodium deoxycholate, and sodium glycocholate; and 0.0005 to 0.2M of a chelating agent selected from the group consisting of ethylenediaminetetraacetic acid, ethylene-bis-(oxyethylene nitrile)tetraacetic acid and orthophenanthrolene.
Claim 3
Dependent Claim
127 words
A process for pasteurizing an aqueous solution consisting essentially of fibronectin to inactivate hepatitis viruses therein while preserving its native character consisting essentially of: heating and simultaneously mechanically agitating said aqueous solution containing fibronectin at 60° to 70° C. 10 to 20 hours to effect pasteurization thereof in the presence of: 25% to 50% w/v of a polyol selected from the group consisting of sucrose, maltose, lactose, glucose, mannose, and galactose; 0.01% to 0.5% w/v of a surface active agent selected from the group consisting of (oxy-1,2-ethanediyl) 20 monododecanoate sorbitan (oxy-1, 2-ethanediyl) 20 monohexadecanoate sorbitan, (oxy-1, 2-ethanediyl) 20 monooctadecanoate sorbitan and (oxy-1, 2-ethanediyl) 20 mono-9octadecanoate sorbitan; and 0.0005 to 0.2M of a chelating agent selected from the group consisting of ethylenediaminetetraacetic acid, ethylene-bis-(oxyethylene nitrile)tetraacetic acid and orthophenanthrolene.
Claim 4
Dependent Claim
127 words
A process for pasteurizing an aqueous solution consisting essentially of fibronectin to inactivate hepatitis viruses therein while preserving its native character consisting essentially of: heating and simultaneously mechanically agitating said aqueous solution containing fibronectin at 60° to 70° C. 10 to 20 hours to effect pasteurization thereof in the presence of: 25% to 50% w/v of a polyol selected from the group consisting of sucrose, maltose, lactose, glucose, mannose, and galactose; 0.01% to 0.5% w/v of a surface active agent selected from the group consisting of (oxy-1,2-ethanediyl) 20 monododecanoate sorbitan (oxy-1, 2-ethanediyl) 20 monohexadecanoate sorbitan, (oxy-1, 2-ethanediyl) 20 monooctadecanoate sorbitan and (oxy-1, 2-ethanediyl) 20 mono-9octadecanoate sorbitan; and 0.0005 to 0.2M of a chelating agent selected from the group consisting of ethylenediaminetetraacetic acid, ethylene-bis-(oxyethylene nitrile)tetraacetic acid and orthophenanthrolene.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-28 | 1989-10-28 | 1990-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-28 | 1993-10-28 | 1994-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-28 | 1997-10-28 | 1998-04-29 | $7700.00 | Window Closed / Lapsed |