Radiopaque polyvinyl-silicone network resin compositions and medical-surgical tubings prepared therefrom

Claim 2

A radiopaque composition comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR8## wherein R 1 is hydrogen or iodo; R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); and, uniformly dispersed therein, (c) a platinum-cured silicone network polymer, the amount of (c) comprising 2 to 30 parts by weight per 100 parts by weight of (a), (b) and (c), wherein said radiopaque composition is essentially free of filler.

Claim 3

A composition according to claim 1 which includes a minor proportion of a radioparent plasticizer and a minor proportion of a heat stabilizer for said vinyl resin.

Claim 4

A composition according to claim 1 wherein, in said radiopacifier (b), each R 1 is iodo and R is (lower)alkyl or (lower)alkoxy(lower)alkyl.

Claim 5

A composition according to claim 1 wherein said radiopacifier (b) is n-butyl 2,3,4,6-tetraiodobenzoate.

Claim 6

A composition according to claim 1 wherein said radiopacifier (b) is 2-ethoxyethyl 2,5-diiodobenzoate.

Claim 7

A composition according to claim 1 wherein said radiopacifier (b) comprises a mixture of n-butyl 2,3,4,6-tetraiodobenzoate and 2-ethoxyethyl 2,5-diiodobenzoate.

Claim 8

A composition as defined in claim 1 which is essentially free of particulate silica.

Claim 9

A composition as defined in claim 1 wherein said platinum-cured silicone network polymer (c) comprises the reaction product of (i) an organic silicon compound having at least two silicon-bonded unsaturated groups per molecule, (ii) a silicon compound containing at least two silicon-bonded hydrogen atoms per molecule, and (iii) a small, catalytically effective amount of a platinum-containing catalyst.

Claim 10

A composition as defined in claim 8 wherein component (i) is of the formula: ##STR9## and component (ii) is of the formula: ##STR10## wherein R is selected from monovalent hydrocarbon radicals free of olefinic unsaturation, halogenated monovalent hydrocarbon radicals free of olefinic unsaturation, cyanoalkyl radicals or a mixture of any of the foregoing; R 1 is selected from vinyl radicals, allyl radicals or a mixture thereof; a has a value of from 1.0 to 2.5; b has a value of from 0.005 to 2.0; and the sum of a plus b is equal to from 1.005 to 3.0.

Claim 11

A composition as defined in claim 9 wherein said platinum-containing catalyst (iii) is selected from chloroplatinic acid, platinum-black, platinum adsorbed on a carrier, a platinum-olefin complex, a platinum-cyclopropane complex or a mixture of any of the foregoing.

Claim 12

A two-part composition adapted for melt blending and thermoforming into radiopaque tubing, Part A comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR11## wherein R 1 is hydrogen or iodo, and R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); and (c)(i) an organic silicon compound having at least two silicon-bonded unsaturated groups per molecule; and Part B comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR12## wherein R 1 is hydrogen or iodo, and R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); (c)(ii) a silicon compound containing at least two silicon-bonded hydrogen atoms per molecule; and (c)(iii) a small, catalytically effective amount of a platinum-containing catalyst, wherein the respective amounts of (c)(i), (ii) and (iii) are selected to provide from about 2 to about 30 parts by weight of a platinum-cured silicone network polymer, after having blended and thermoformed parts A and B, per 100 parts by weight of the total composition, and wherein said two-part composition is essentially free of filler.

Claim 13

A two-part composition adapted for melt blending and thermoforming into radiopaque tubing, Part A comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR11## wherein R 1 is hydrogen or iodo, and R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); and (c)(i) an organic silicon compound having at least two silicon-bonded unsaturated groups per molecule; and Part B comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR12## wherein R 1 is hydrogen or iodo, and R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); (c)(ii) a silicon compound containing at least two silicon-bonded hydrogen atoms per molecule; and (c)(iii) a small, catalytically effective amount of a platinum-containing catalyst, wherein the respective amounts of (c)(i), (ii) and (iii) are selected to provide from about 2 to about 30 parts by weight of a platinum-cured silicone network polymer, after having blended and thermoformed parts A and B, per 100 parts by weight of the total composition, and wherein said two-part composition is essentially free of filler.

Claim 14

A two-part composition as defined in claim 11 wherein in said radiopacifier (b), each R 1 is iodo and R is (lower)alkyl or (lower)alkoxy(lower)alkyl.

Claim 15

A two-part composition as defined in claim 11 wherein said radiopacifier (b) is selected from n-butyl 2,3,4,6-tetraidobenzoate, 2-ethoxyethyl 2,5-diiodobenzoate or a mixture of the foregoing.

Claim 16

A two-part composition as defined in claim 11 which is essentially free of particulate silica.

Claim 17

A two part composition as defined in claim 11 wherein component (c)(i) of Part A is of the formula: ##STR13## and component (c)(ii) of Part B is of the formula: ##STR14## where R is selected from monovalent hydrocarbon radicals free of olefinic unsaturation, halogenated monovalent hydrocarbon radicals free of olefinic unsaturation and cyanoalkyl radicals or a mixture of any of the foregoing; R 1 is selected from vinyl radicals, allyl radicals or a mixture thereof; a has a value of from 1.0 to 2.5; b has a value of from 0.005 to 2.0; and the sum of a plus b is equal to from 1.005 to 3.0.

Claim 18

A two-part composition as defined in claim 15 wherein component (c)(iii) is selected from chloroplatinic acid, platinum black, platinum adsorbed on a carrier, a platinum-olefin complex, a platinum-cyclopropane complex or a mixture of any of the foregoing.

Claim 19

Medical-surgical tubing comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR15## wherein R 1 is hydrogen or iodo, and R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier (b) comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); and, uniformly dispersed therein, (c) a platinum-cured silicone network polymer, the amount of (c) comprising 8 to 30 parts by weight per 100 parts by weight of (a), (b) and (c), wherein said medical-surgical tubing is essentially free of filler.

Claim 20

Medical-surgical tubing comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR15## wherein R 1 is hydrogen or iodo, and R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier (b) comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); and, uniformly dispersed therein, (c) a platinum-cured silicone network polymer, the amount of (c) comprising 8 to 30 parts by weight per 100 parts by weight of (a), (b) and (c), wherein said medical-surgical tubing is essentially free of filler.

Claim 21

Medical-surgical tubing according to claim 17 which includes a minor proportion of a radioparent plasticizer and a minor proportion of a heat stabilizer for said vinyl resin.

Claim 22

Medical-surgical tubing as defined in claim 17 wherein, in said radiopacifier (b), each R 1 is iodo and R is (lower)alkyl or (lower)alkoxy(lower)alkyl.

Claim 23

Medical-surgical tubing as defined in claim 17 wherein said radiopacifier (b) is n-butyl 2,3,4,6-tetraiodobenzoate.

Claim 24

Medical-surgical tubing as defined in claim 17 wherein said radiopacifier (b) is 2-ethoxyethyl 2,5-diiodobenzoate.

Claim 25

Medical-surgical tubing as defined in claim 17 wherein said radiopacifier (b) is a mixture of n-butyl 2,3,4,6-tetraiodobenzoate and 2-ethoxyethyl 2,5-diiodobenzoate.

Claim 26

Medical-surgical tubing as defined in claim 17 which also includes as a partial replacement for said radiopacifier (b) a compound selected from bismuth oxychloride or barium sulfate in an amount sufficient to enhance the radiopacity of said tubing while maintaining its tensile strength.

Claim 27

Medical-surgical tubing as defined in claim 17 which is essentially free of particulate silica.

Claim 28

Medical-surgical tubing as defined in claim 17 wherein said platinum-cured silicone network polymer (c) comprises the reaction product of: (i) an organic silicon compound having at least two silicon-bonded unsaturated groups per molecule, (ii) a silicon compound containing at least two silicon-bonded hydrogen atoms per molecule, and (iii) a small, catalytically effective amount of a platinum-containing catalyst.

Claim 29

Medical-surgical tubing as defined in claim 25 wherein component (i) is of the formula: ##STR16## and component (ii) is of the formula: ##STR17## where R is selected from monovalent hydrocarbon radicals free of olefinic unsaturation, halogenated monovalent hydrocarbon radicals free of olefinic unsaturation and cyanoalkyl radicals or a mixture of any of the foregoing; R 1 is selected from vinyl radicals, allyl radicals or a mixture thereof; a has a value of from 1.0 to 2.5; b has a value of from 0.005 to 2.0; and the sum of a plus b is equal to from 1.005 to 3.0.

Claim 30

Medical-surgical tubing as defined in claim 26 wherein component (iii) is selected from chloroplatinic acid, platinum black, platinum adsorbed on a carrier, a platinum-olefin complex, platinum-cyclopropane complex or a mixture of any of the foregoing.

Claim 31

A medical-surgical catheter formed from the tubing of claim 17.

Claim 32

A medical-surgical tubing comprising: (1) an interior tubular portion comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; and (2) a concentric outer shell comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR18## wherein R 1 is hydrogen or iodo, and R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier (b) comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); and, uniformly dispersed therein, (c) a platinum-cured, silicone network polymer, the amount of (c) comprising 2 to 30 parts by weight per 100 parts by weight of (a), (b) and (c), wherein said medical-surgical tubing is essentially free of filler.

Claim 33

A medical-surgical tubing comprising: (1) an interior tubular portion comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; and (2) a concentric outer shell comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR18## wherein R 1 is hydrogen or iodo, and R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier (b) comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); and, uniformly dispersed therein, (c) a platinum-cured, silicone network polymer, the amount of (c) comprising 2 to 30 parts by weight per 100 parts by weight of (a), (b) and (c), wherein said medical-surgical tubing is essentially free of filler.

Claim 34

A medical-surgical tubing as defined in claim 29 wherein, in said radiopacifier (b), each R 1 is iodo and R is (lower)alkyl or (lower)alkoxy(lower)alkyl.

Claim 35

A medical-surgical tubing as defined in claim 29 wherein said radiopacifier (b) is n-butyl 2,3,4,6-tetraiodobenzoate.

Claim 36

A medical-surgical tubing as defined in claim 29 wherein said radiopacifier (b) is 2-ethoxyethyl 2,5-diiodobenzoate.

Claim 37

A medical-surgical tubing as defined in claim 29 wherein said radiopacifier (b) comprises a mixture of n-butyl 2,3,4,6-tetraiodobenzoate and 2-ethoxyethyl 2,5-diiodobenzoate.

Claim 38

A medical-surgical tubing as defined in claim 29 which is essentially free of particulate silica.

Claim 39

A medical-surgical tubing as defined in claim 29 wherein said platinum-cured silicone network polymer (c) comprises the reaction product of (i) an organic silicon compound having at least two silicon-bonded unsaturated groups per molecule, (ii) a silicon compound containing at least two silicon-bonded hydrogen atoms per molecule, and (iii) a small, catalytically effective amount of a platinum-containing catalyst.

Claim 40

A composition as defined in claim 35 wherein component (i) is of the formula: ##STR19## and component (ii) is of the formula: ##STR20## where R is selected from monovalent hydrocarbon radicals free of olefinic unsaturation, halogenated monovalent hydrocarbon radicals free of olefinic unsaturation, cyanoalkyl radicals or a mixture of any of the foregoing; R 1 is selected from vinyl radicals, allyl radicals or a mixture thereof; a has a value of from 1.0 to 2.5; b has a value of from 0.005 to 2.0; and the sum of a plus b is equal to from 1.005 to 3.0.

Claim 41

A medical-surgical tubing as defined in claim 36 wherein said platinum-containing catalyst (iii) is selected from chloroplatinic acid, platinum black, platinum adsorbed on a carrier, a platinum-olefin complex, a platinum-cyclopropane complex or a mixture of any of the foregoing.

Claim 42

A medical-surgical tubing comprising: (1) a relatively thick interior tubular portion which is visually transparent and transparent to x-ray radiation comprising: (a) a thermoplastic material; and (2) a thin concentric outer shell which is visually transparent and strongly radiopaque comprising: (a) a thermoplastic material; (b) a radiopacifier which is an organic iodine compound; and (c) a platinum-cured silicone network polymer, the amount of (c) comprising 2 to 30 parts by weight per 100 parts by weight of (a), (b) and (c), said outer shell being co-extruded with and bonded to said interior portion, said outer shell having an external surface essentially free of exposed filler and rendered smooth and hard by extrusion.

Claim 43

A medical-surgical tubing comprising: (1) a relatively thick interior tubular portion which is visually transparent and transparent to x-ray radiation comprising: (a) a thermoplastic material; and (2) a thin concentric outer shell which is visually transparent and strongly radiopaque comprising: (a) a thermoplastic material; (b) a radiopacifier which is an organic iodine compound; and (c) a platinum-cured silicone network polymer, the amount of (c) comprising 2 to 30 parts by weight per 100 parts by weight of (a), (b) and (c), said outer shell being co-extruded with and bonded to said interior portion, said outer shell having an external surface essentially free of exposed filler and rendered smooth and hard by extrusion.

Claim 44

A medical-surgical tubing as defined in claim 38 wherein component (a) of said inner and outer portions is a polyvinyl thermoplastic.

Claim 45

A medical-surgical tubing as defined in claim 38 wherein the tubing has a diameter of at least three-eights inch, and the outer shell has a wall thickness of 0.020 inch.

Claim 46

A medical-surgical tubing as defined in claim 38 wherein the inner tubular portion has relatively high flexibility and softness, said shell having greater hardness and torque resistance than said inner portion.

Claim 47

A medical-surgical tubing as defined in claim 38 wherein said radiopacifier (b) is of the formula: ##STR21## wherein R 1 is hydrogen or iodo, and R is alkyl or alkoxyalkyl or a mixture of said compounds.

Claim 48

A medical-surgical tubing as defined in claim 42 wherein, in said radiopacifier (b), each R 1 is iodo and R is (lower)alkyl or (lower)alkoxy(lower)alkyl.

Claim 49

A medical-surgical tubing as defined in claim 38 wherein said radiopacifier (b) is n-butyl 2,3,4,6-tetraiodobenzoate.

Claim 50

A medical-surgical tubing as defined in claim 38 wherein said radiopacifier (b) is 2-ethoxyethyl 2,5-diiodobenzoate.

Claim 51

A medical-surgical tubing as defined in claim 38 wherein said radiopacifier (b) comprises a mixture of n-butyl 2,3,4,6-tetraiodobenzoate and 2-ethoxyethyl 2,5-diiodobenzoate.

Claim 52

A medical-surgical tubing as defined in claim 38 which is essentially free of particulate silica.

Claim 53

A medical-surgical tubing as defined in claim 38 wherein said platinum-cured silicone network polymer (c) comprises the reaction product of (i) an organic silicon compound having at least two silicon-bonded unsaturated groups per molecule, (ii) a silicon compound containing at leat two silicon-bonded hydrogen atoms per molecule, and (iii) a small, catalytically effective amount of a platinum-containing catalyst.

Claim 54

A medical-surgical tubing as defined in claim 48 wherein component (i) is of the formula: ##STR22## and component (ii) is of the formula: ##STR23## where R is selected from monovalent hydrocarbon radicals free of olefinic unsaturation, halogenated monovalent hydrocarbon radicals free of olefinic unsaturation, cyanoalkyl radicals or a mixture of any of the foregoing, R 1 is selected from vinyl radicals, allyl radicals or a mixture thereof; a has a value of from 1.0 to 2.5; b has a value of from 0.005 to 2.0; and the sum of a plus b is equal to from 1.005 to 3.0.

Claim 55

A medical-surgical tubing as defined in claim 49 wherein said platinum-containing catalyst (iii) is selected from chloroplatinic acid, platinum black, platinum adsorbed on a carrier, a platinum-olefin complex, a platinum-cyclopropane complex or a mixture of any of the foregoing.

Claim 56

A medical-surgical tubing comprising: (1) an interior tubular portion comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR24## wherein R 1 is hydrogen or iodo; R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); and, uniformly dispersed therein, (c) a platinum-cured, silicone network polymer, the amount of (c) comprising 2 to 30 parts by weight per 100 parts by weight of (a), (b) and (c); and (2) a concentric outer shell comprising: (a) a thermoplastic polyurethane resin, wherein said medical-surgical tubing provides a surface essentially free of exposed filler.

Claim 57

A medical-surgical tubing comprising: (1) an interior tubular portion comprising: (a) a vinyl resin which is a polymer or copolymer of a halogenated vinyl monomer; (b) a radiopacifier therefor consisting of a diiodobenzoate or a tetraiodobenzoate compound of the formula: ##STR24## wherein R 1 is hydrogen or iodo; R is alkyl or alkoxyalkyl or a mixture of said compounds, said radiopacifier comprising 20 to 50 parts by weight per 100 parts by weight of (a) and (b); and, uniformly dispersed therein, (c) a platinum-cured, silicone network polymer, the amount of (c) comprising 2 to 30 parts by weight per 100 parts by weight of (a), (b) and (c); and (2) a concentric outer shell comprising: (a) a thermoplastic polyurethane resin, wherein said medical-surgical tubing provides a surface essentially free of exposed filler.