US4582839A
Expired / Lapsed
US
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2,4-thiazolidinediones
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1984-09-21
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Granted: 1986-04-15
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Expires: 2004-09-21
Abstract
Abstract Thiazolidinedione derivatives of the general formula: ##STR1## wherein R 1 and R 2 are the same or different and each represent hydrogen or a lower alkyl group; R 3 is hydrogen or an acyl group; n is 0 or 1 and salts thereof are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, and are of value as a therapeutic agent for diabetes and therapeutic agent for hyperlipemia.
Inventors
- 👤 Kanji Meguro
- 👤 Takeshi Fujita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 16:38
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/28; C07D213/30; C07D213/89; C07D417/00; C07D417/02; C07D417/12
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
60 words
A thiazolidinedione derivative of the formula: ##STR8## wherein R 1 and R 2 are the same or different and each represent hydrogen or a lower alkyl group; R 3 is hydrogen or formyl, alkylcarbonyl having 2 to 6 carbon atoms, phenylacetyl,phenylpropionyl, benzoyl or p-toluoyl; n is 0 or 1 or a pharmaceutical acid addition salt or a base salt thereof.
Claim 2
Dependent Claim
60 words
A thiazolidinedione derivative of the formula: ##STR8## wherein R 1 and R 2 are the same or different and each represent hydrogen or a lower alkyl group; R 3 is hydrogen or formyl, alkylcarbonyl having 2 to 6 carbon atoms, phenylacetyl,phenylpropionyl, benzoyl or p-toluoyl; n is 0 or 1 or a pharmaceutical acid addition salt or a base salt thereof.
Claim 3
Dependent Claim
73 words
A blood sugar-and lipid-lowering composition which contains an effective amount of a thiazolidinedione derivative of the formula: ##STR9## wherein R 1 and R 2 are the same or different and each represent hydrogen or a lower alkyl group; R 3 is hydrogen or formyl, alkylcarbonyl having 2 to 6 carbon atoms, phenylacetyl, phenylpropionyl, benzoyl or p-toluoyl; n is 0 or 1 or a pharmaceutical acid addition salt or a pharmaceutical base salt thereof.
Claim 4
Dependent Claim
73 words
A blood sugar-and lipid-lowering composition which contains an effective amount of a thiazolidinedione derivative of the formula: ##STR9## wherein R 1 and R 2 are the same or different and each represent hydrogen or a lower alkyl group; R 3 is hydrogen or formyl, alkylcarbonyl having 2 to 6 carbon atoms, phenylacetyl, phenylpropionyl, benzoyl or p-toluoyl; n is 0 or 1 or a pharmaceutical acid addition salt or a pharmaceutical base salt thereof.
Claim 5
Dependent Claim
11 words
The compound as claimed in claim 1, wherein n is zero.
Claim 6
Dependent Claim
12 words
The compound as claimed in claim 1, wherein R 3 is hydrogen.
Claim 7
Dependent Claim
12 words
The compound as claimed in claim 1, wherein the compound is 5-{4-[2-(5-ethyl-2-pyridyl)-2-hydroxyethoxy]benzyl}-2,4-thiaxolidinedione.
Claim 8
Dependent Claim
12 words
The compound as claimed in claim 1, wherein the compound is 5-{4-[2-hydroxy-2-(2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione.
Claim 9
Dependent Claim
12 words
The compound as claimed in claim 1, wherein the compound is 5-{4-[2-hydroxy-2-(6-methyl-2-pyridyl)ethoxyl]benzyl}-2,4-thiazolidinedione.
Claim 10
Dependent Claim
12 words
The compound as claimed in claim 1, wherein the compound is 5-{4-[2-hydroxy-2-(3-methyl-2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-14 | 1989-10-14 | 1990-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-14 | 1993-10-14 | 1994-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-14 | 1997-10-14 | 1998-04-15 | $7700.00 | Window Closed / Lapsed |