Patent US4582821A successfully refreshed from Google Patents.
US4582821A
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Inhibition of cyclic nucleotide independent protein kinases
Assignee: Cornell Research Foundation Inc
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Filing: 1983-11-16
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Granted: 1986-04-15
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Expires: 2003-11-16
Abstract
Abstract Peptide and amino acid halomethyl ketones are employed in processes for inhibiting cyclic nucleotide independent protein kinase activity and tumor cell growth.
Inventors
- 👤 Charles A. Kettner
- 👤 Efraim Racker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 14:12
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1016; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/144
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
104 words
A process for inhibiting the growth of tumor cells in a medium, comprising contacting the cells with an effective amount of a compound of the formula ##STR3## or a physiologically acceptable salt thereof, wherein R 1 is hydrogen or an N-terminal protecting group; R 2 is methyl, isopropyl, isobutyl, or 4-hydroxybenzyl; A 1 is an amino acid residue selected from the group consisting of Phe, Ser, Leu, Lys and Ala; A 2 and A 3 are independently selected from the group consisting of Phe, Gly, Ala, Pro, Leu, Lys, or Ser; X is Cl or Br; and N, o and p are each 1.
Claim 2
Dependent Claim
104 words
A process for inhibiting the growth of tumor cells in a medium, comprising contacting the cells with an effective amount of a compound of the formula ##STR3## or a physiologically acceptable salt thereof, wherein R 1 is hydrogen or an N-terminal protecting group; R 2 is methyl, isopropyl, isobutyl, or 4-hydroxybenzyl; A 1 is an amino acid residue selected from the group consisting of Phe, Ser, Leu, Lys and Ala; A 2 and A 3 are independently selected from the group consisting of Phe, Gly, Ala, Pro, Leu, Lys, or Ser; X is Cl or Br; and N, o and p are each 1.
Claim 3
Dependent Claim
21 words
A process according to claim 1, wherein R 1 is an arylcarbonyl, alkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl, arylsulfonyl, or arylsulfenyl protecting group.
Claim 4
Dependent Claim
13 words
A process according to claim 2, wherein R 2 is isobutyl or 4-hydroxybenzyl.
Claim 5
Dependent Claim
35 words
A process according to claim 3, wherein R 1 is Z; R 2 is isobutyl or 4-hydroxybenzyl; A 1 is Lys or Ala; A 2 is Gly; A 3 is Phe; and X is Cl.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-14 | 1989-10-14 | 1990-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-14 | 1993-10-14 | 1994-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-14 | 1997-10-14 | 1998-04-15 | $7700.00 | Window Closed / Lapsed |