Clot activator for serum separation tubes

Claim 2

A process for producing and utilizing a blood clot activator material, characterized by the steps of (a) forming a mixture by admixing ethylsilicate and ethyl alcohol; (b) initiating hydrolysis of the mixture formed from said forming step by adding a reactant selected from the group consisting of ammonia, acetic acid, sulphuric acid, and hydrochloric acid; (c) partially hydrolyzing said mixture from said adding step, by introducing therein less than a stoichiometric quantity of water; (d) maintaining in a first maintaining step said mixture from said partial hydrolysis step at room temperature while stirring for a period of time sufficient to polymerize said ethylsilicate into a solidified form of glass; (e) maintaining in a second maintaining step said solidified glass obtained from said first maintaining step at room temperature for a period of time sufficient to dry said solidified glass; (f) maintaining in a third maintaining step said solidified glass from said second maintaining step at an elevated temperature within the range of between about 110° C. and 120° C. to break down said solidified glass into small pieces; and (g) introducing a quantity of said small pieces from said third maintaining step into each of a plurality of blood collection containers; (h) whereby blood samples subsequently introduced into said plurality of blood collection containers are caused to clot.

Claim 3

The process of claim 1, further characterized by (a) said forming step being carried out with a mixture of ethylsilicate and ethyl alcohol in the ratio of 1:1 by volume.

Claim 4

The process of claim 1, further characterized by (a) said second maintaining step being carried out for within the range of between about 2 and 3 hours.

Claim 5

The process of claim 1, further characterized by (a) said small pieces from said third maintaining step being of a size within the range of between about 2 millimeters by 2 millimeters and 2 millimeters by 10 millimeters.

Claim 6

In a blood sample collection device having means for activating blood clotting properties comprising (a) a container having an opening; (b) a closure for said opening; (c) a quantity of an amorphous rigid porous glass in said container; wherein the improvement comprises said glass being amorphous porous imperfect glass material obtained by the process of (d) forming a mixture by admixing ethylsilicate and ethyl alcohol; (e) initiating hydrolysis of the mixture formed from said forming step by adding a reactant selected from the group consisting of ammonia, acetic acid, sulphuric acid and hydrochloric acid; (f) partially hydrolyzing said mixture from said adding step, by introducing therein less than a stoichiometric quantity of water; (g) maintaining in a first maintaining step said mixture from said partial hydrolysis step at room temperature while stirring for a period of time sufficient to polymerize said ethylsilicate into a solidified form of glass; (h) maintaining in a second maintaining step said solidified glass obtained from said first maintaining step at room temperature for a period of time sufficient to dry said solidified glass; (i) maintaining in a third maintaining step said solidified glass from said second maintaining step at an elevated temperature within the range of between about 110° C. and 120° C. to break down said solidified glass into small pieces; and (j) introducing a quantity of said small pieces from said third maintaining step into said container opening; (k) whereby a blood sample subsequently introduced into said container is caused to clot.

Claim 7

In a blood sample collection device having means for activating blood clotting properties comprising (a) a container having an opening; (b) a closure for said opening; (c) a quantity of an amorphous rigid porous glass in said container; wherein the improvement comprises said glass being amorphous porous imperfect glass material obtained by the process of (d) forming a mixture by admixing ethylsilicate and ethyl alcohol; (e) initiating hydrolysis of the mixture formed from said forming step by adding a reactant selected from the group consisting of ammonia, acetic acid, sulphuric acid and hydrochloric acid; (f) partially hydrolyzing said mixture from said adding step, by introducing therein less than a stoichiometric quantity of water; (g) maintaining in a first maintaining step said mixture from said partial hydrolysis step at room temperature while stirring for a period of time sufficient to polymerize said ethylsilicate into a solidified form of glass; (h) maintaining in a second maintaining step said solidified glass obtained from said first maintaining step at room temperature for a period of time sufficient to dry said solidified glass; (i) maintaining in a third maintaining step said solidified glass from said second maintaining step at an elevated temperature within the range of between about 110° C. and 120° C. to break down said solidified glass into small pieces; and (j) introducing a quantity of said small pieces from said third maintaining step into said container opening; (k) whereby a blood sample subsequently introduced into said container is caused to clot.

Claim 8

The device of claim 5, further characterized by (a) said container is an evacuated container.

Claim 9

The device of claim 5, further characterized by (a) said forming step being carried out with a mixture of ethylsilicate and ethyl alcohol in the ratio of 1:1 by volume.

Claim 10

The device of claim 5, further characterized by (a) said second maintaining step being carried out for within the range of between about 2 and 3 hours.

Claim 11

The device of claim 5, further characterized by (a) said small pieces from said third maintaining step being of a size within the range of between about 2 millimeters by 2 millimeters and 2 millimeters by 10 millimeters.

Claim 12

The device of claim 5, further characterized by (a) said container is an evacuated serum separation tube having an open end and a closed end; and (b) a thixotropic gel positioned in the closed end of said tube prior to said introducing step.

Claim 13

An amorphous porous imperfect glass material in the form of pieces for introduction into blood sample collection devices for enhancing clot activation of blood samples subsequently introduced into such devices, said glass pieces obtained by the process of (a) forming a mixture by admixing ethylsilicate and ethyl alcohol; (b) initiating hydrolysis of the mixture formed from said forming step by adding a reactant selected from the group consisting of ammonia, acetic acid, sulphuric acid and hydrochloric acid; (c) partially hydrolyzing said mixture from said adding step, by introducing therein less than a stoichiometric quantity of water; (d) maintaining in a first maintaining step said mixture from said partial hydrolysis step at room temperature while stirring for a period of time sufficient to polymerize said ethylsilicate into a solidified form of glass; (e) maintaining in a second maintaining step said solidified glass obtained from said first maintaining step at room temperature for a period of time sufficient to dry said solidified glass; (f) maintaining in a third maintaining step said solidified glass from said second maintaining step at an elevated temperature within the range of between about 110° C. and 120° C. to break down said solidified glass into small pieces.

Claim 14

An amorphous porous imperfect glass material in the form of pieces for introduction into blood sample collection devices for enhancing clot activation of blood samples subsequently introduced into such devices, said glass pieces obtained by the process of (a) forming a mixture by admixing ethylsilicate and ethyl alcohol; (b) initiating hydrolysis of the mixture formed from said forming step by adding a reactant selected from the group consisting of ammonia, acetic acid, sulphuric acid and hydrochloric acid; (c) partially hydrolyzing said mixture from said adding step, by introducing therein less than a stoichiometric quantity of water; (d) maintaining in a first maintaining step said mixture from said partial hydrolysis step at room temperature while stirring for a period of time sufficient to polymerize said ethylsilicate into a solidified form of glass; (e) maintaining in a second maintaining step said solidified glass obtained from said first maintaining step at room temperature for a period of time sufficient to dry said solidified glass; (f) maintaining in a third maintaining step said solidified glass from said second maintaining step at an elevated temperature within the range of between about 110° C. and 120° C. to break down said solidified glass into small pieces.

Claim 15

The blood clot activator material of claim 11, further characterized by (a) said forming step being carried out with a mixture of ethylsilicate and ethyl alcohol in the ratio of 1:1 by volume.

Claim 16

The blood clot activator material of claim 11, further characterized by (a) said second maintaining step being carried out for within the range of between about 2 and 3 hours.

Claim 17

The blood clot activator material of claim 11, further characterized by (a) said small pieces from said third maintaining step being of a size within the range of between about 2 millimeters by 2 millimeters and 2 millimeters by 10 millimeters.