US4578465A
Expired / Lapsed
US
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Phenyliperazine derivatives
Assignee: Chugai Pharmaceutical Co Ltd
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Filing: 1984-04-30
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Granted: 1986-03-25
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Expires: 2004-04-30
Abstract
Abstract Phenylpiperazine derivatives of the formula: ##STR1## wherein R 1 is a hydrogen atom or a straight- or branched-chain saturated or unsaturated alkyl group having 1 to 8 carbon atoms which may be substituted at any position by a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group or an oxo group; and R 2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group, and a process for producing the same are disclosed. The derivatives of the formula have alpha blocking and serotonin antagonizing activities and are useful as a drug.
Inventors
- 👤 Hiroyuki Nagano
- 👤 Mitiro Takagi
- 👤 Noboru Kubodera
- 👤 Isao Matsunaga
- 👤 Hiroyuki Nabata
- 👤 Yasuhiro Ohba
- 👤 Kazushige Sakai
- 👤 Shun-ichi Hata
- 👤 Yasumi Uchida
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 06:26
CPC Classifications
C; C07; C07D; C07D403/00; C07D403/02; C07D403/06; C07D239/00; C07D239/70; C07D239/72; C07D239/95; C07D239/96; A; A61; A61P; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
70 words
A phenylpiperazine derivative of the formula: ##STR4## wherein R 1 is a hydrogen atom or a straight- or branched-chain saturated or unsaturated alkyl group having 1 to 8 carbon atoms which may be substituted at any position by a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group or an oxo group; and R 2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group.
Claim 2
Dependent Claim
70 words
A phenylpiperazine derivative of the formula: ##STR4## wherein R 1 is a hydrogen atom or a straight- or branched-chain saturated or unsaturated alkyl group having 1 to 8 carbon atoms which may be substituted at any position by a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group or an oxo group; and R 2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group.
Claim 3
Dependent Claim
31 words
A compound according to claim 1 which is represented by the formula: ##STR5## (wherein R 2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group).
Claim 4
Dependent Claim
13 words
A compound according to claim 2 which is represented by the formula: ##STR6##
Claim 5
Dependent Claim
51 words
A compound of the formula: ##STR7## (wherein R 2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group; A is a straight- or branched-chain alkylene group having 1 to 7 carbon atoms; Z is a hydroxyl group, a carboxyl group or a lower alkoxycarbonyl group).
Claim 6
Dependent Claim
51 words
A compound of the formula: ##STR7## (wherein R 2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group; A is a straight- or branched-chain alkylene group having 1 to 7 carbon atoms; Z is a hydroxyl group, a carboxyl group or a lower alkoxycarbonyl group).
Claim 7
Dependent Claim
57 words
A compound according to claim 4 which is represented by the formula: ##STR8## (wherein R 2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group; R 3 is a hydrogen atom or a lower alkyl group having 1 to 3 carbon atoms; and n is an integer of 1 to 7).
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-24 | 1989-09-23 | 1990-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-24 | 1993-09-23 | 1994-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-24 | 1997-09-23 | 1998-03-25 | $7700.00 | Window Closed / Lapsed |