3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
Abstract
Abstract 3 - (1 - PIPERAZINYLALKYL)-2,4-QUINAZOLINEDIONES FURTHER SUBSTITUTED AT THE 4-PISTON OF THE PIPERAZINE RING BY OETHYLTHIOPHENYL, O-PROPYLTHIOOPHENYL, OR O-ISOPROPYLTHIOPHENYL; N-METHYL DERIVATIVES; AND ACID-ADDITION SALTS. THE COMPOUNDS ARE PHARMACOLOGICAL AGENTS, ESPECIALLY CENTRAL NERVOUS SYSTEM DEPRESSANTS OF THE TYPE KNOWN AS MAJOR TRANQUILIZNG AGENTS. THEY EXHIBIT CEREBRAL DERESSANT ACTIVITY AND SUPPRESS CONDITIONED AVOIDANCE BEHAVIOR. THE N-METHYLATED DERIVATIVES CAN BE PRODUCED BY METHYLATION OF THE CORRESPONDING UNMETHYLATED COMPOUNDS WITH AN N,N-DI(LOWER ALKYL) FORMAMIDE DIMETHYL ACETAL. THE UNMETHYLATED COMPOUNDS CAN BE PRODUCED BY A RING CLOSURE REACTION OF AN O-AMINOBENZAMIDE COMPOUND WITH PHOSGENE. STARTING MATERIALS CAN BE PRODUCED FROM VARIOUS PIPERAZINE DERIVATIVES.
Inventors
- 👤 R Parcell
Bibliographic Details
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