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US4578191A
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Bio-artificial ultrafiltration pancreas
Assignee: Centre National de la Recherche Scientifique
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Filing: 1983-08-01
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Granted: 1986-03-25
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Expires: 2003-08-01
Abstract
Abstract The bio-artifical pancreas comprises islands of Langerhans contained in a volume defined by two approximately parallel ultrafiltration membranes, able to be formed by two successive portions of the same flat membrane or the same hollow fiber. The surfaces of the membrane opposite the volume occupied by the islands are successively swept by the same blood stream over a length greater by at least one order of size than the distance separating the membranes.
Inventors
- 👤 Michel Jaffrin
- 👤 Gerard Reach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:52
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/022; A61M; A61M1/00; A61M1/36; A61M1/3687; A61M1/3689; A61M1/80
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
121 words
A bio-artificial pancreas comprising: two ultrafiltration membranes having approximately parallel substantially planar confronting surfaces spaced apart a distance such that the space there between defines a volume of small thickness; islets of Langerhans contained in said compartment; means defining a blood path whereby blood flowing along said blood path successively sweeps said surfaces of said two membranes opposite said volume occupied by said islets of Langerhans over a length greater by at least one order of magnitude than the distance which separates said membranes; said membranes being constructed and arranged such that said volume fulfills the condition; V.sub.i ≦(S)(P.sub.M)(τ)(ΔP/8) in which V i =said volume, S=total membrane area, P M =hydraulic permeability of membrane, τ=acceptable time constant, and ΔP=available drive pressure.
Claim 2
Dependent Claim
121 words
A bio-artificial pancreas comprising: two ultrafiltration membranes having approximately parallel substantially planar confronting surfaces spaced apart a distance such that the space there between defines a volume of small thickness; islets of Langerhans contained in said compartment; means defining a blood path whereby blood flowing along said blood path successively sweeps said surfaces of said two membranes opposite said volume occupied by said islets of Langerhans over a length greater by at least one order of magnitude than the distance which separates said membranes; said membranes being constructed and arranged such that said volume fulfills the condition; V.sub.i ≦(S)(P.sub.M)(τ)(ΔP/8) in which V i =said volume, S=total membrane area, P M =hydraulic permeability of membrane, τ=acceptable time constant, and ΔP=available drive pressure.
Claim 3
Dependent Claim
23 words
The bio-artificial pancreas according to claim 1, wherein said membranes are two successive portions of the same flat membrane folded in a U.
Claim 4
Dependent Claim
29 words
The bio-artificial pancreas according to claim 2 further comprising a lattice defining the thickness of said volume and reducing said volume, said lattice being located between said confronting surfaces.
Claim 5
Dependent Claim
20 words
The bio-artificial pancreas according to claim 3, wherein the islets of Langerhans are disposed in the openings of said lattice.
Claim 6
Dependent Claim
26 words
The bio-artificial pancreas according to claim 2, wherein said volume only contains islets of Langerhans in the part distant from the curved end of the U.
Claim 7
Dependent Claim
29 words
The bio-artificial pancreas according to claim 2, wherein the path of the blood stream presents a constriction for creating a pressure drop proximate the curved end of the U.
Claim 8
Dependent Claim
23 words
The bio-artificial pancreas according to claim 1, wherein said two ultrafiltration membranes comprise approximately parallel confronting walls of a U-shaped hollow ultrafiltrating fiber.
Claim 9
Dependent Claim
22 words
A bio-artificial pancreas according to claim 1 wherein said islets of Langerhans are located in a cloth bag accommodated in said volume.
Claim 10
Dependent Claim
31 words
A bio-artificial pancreas according to claim 1 further comprising a member for supporting said membranes and wherein said blood path comprises one or more grooves formed in said membrane supporting member.
Claim 11
Dependent Claim
39 words
A bio-artificial pancreas according to claim 1 wherein said ultrafiltration membranes comprise a hollow ultrafiltration fiber formed into two mutually parallel substantially planar sheets forming said confronting planar surfaces, said blood path defining means comprising said hollow ultrafiltration fiber.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-24 | 1989-09-23 | 1990-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-24 | 1993-09-23 | 1994-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-24 | 1997-09-23 | 1998-03-25 | $7700.00 | Window Closed / Lapsed |