US4575498A
Expired / Lapsed
US
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Method for restoring depleted purine nucleotide pools
Assignee: Duke University
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Filing: 1983-07-21
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Granted: 1986-03-11
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Expires: 2003-07-21
Abstract
Abstract A method of increasing the rate of repletion of purine nucleotide pools in tissue deficient in the nucleotides, which comprises administering to a human or animal a therapeutically effect amount of 5-amino-4-imidazolecarboxamide riboside, 5-amino-4-imidazolecarboxamide, or a pharmaceutically acceptable salt thereof sufficient to increase the rate of the repletion is disclosed along with pharmaceutical compositions useful for carrying out the method of the invention.
Inventors
- 👤 Edward W. Holmes
- 👤 Judith L. Swain
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 05:06
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/052
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
49 words
A method of increasing the rate of repletion of adenosine triphosphate and guanosine triphosphate nucleotides in a tissue deficient in said nucleotides, which comprises: administering to said tissue a therapeutically effect amount of 5-amino-4-imidazolecarboxamide riboside or a pharmaceutically acceptable salt thereof sufficient to increase the rate of said repletion.
Claim 2
Independent Claim
49 words
A method of increasing the rate of repletion of adenosine triphosphate and guanosine triphosphate nucleotides in a tissue deficient in said nucleotides, which comprises: administering to said tissue a therapeutically effect amount of 5-amino-4-imidazolecarboxamide riboside or a pharmaceutically acceptable salt thereof sufficient to increase the rate of said repletion.
Claim 3
Dependent Claim
15 words
The method of claim 1, wherein said amount is from 0.1 to 2.0 μmole/m in/kg.
Claim 4
Dependent Claim
14 words
The method of claim 1, wherein said amount is from 0.2 to 1.0 μmole/min/kg.
Claim 5
Dependent Claim
11 words
The method of claim 1, wherein said compound is 5-amino-4-imdazolecarboxyamide riboside.
Claim 6
Dependent Claim
17 words
The method of claim 4, wherein the amount of said compound is from 0.2 to 1.0 μmole/min/kg.
Claim 7
Dependent Claim
15 words
The method of claim 1, wherein said administering is to a tissue in a human.
Claim 8
Dependent Claim
11 words
The method of claim 6, wherein said tissue is myocardial tissue.
Claim 9
Dependent Claim
19 words
The method of claim 7, wherein said compound is administered in an amount of from 0.2 to 1.0 μmole/min/kg.
Claim 10
Dependent Claim
19 words
The method of claim 1, wherein said administering is to a tissue maintained outside a human or animal body.
Claim 11
Dependent Claim
14 words
The method of claim 9, wherein said amount is from 0.1 to 2.0 μmole/min/kg.
Claim 12
Dependent Claim
14 words
The method of claim 9, wherein said amount is from 0.2 to 1.0 μmole/min/kg.
Claim 13
Dependent Claim
11 words
The method of claim 9, wherein said compound is 5-amino-4-imidazolecarboxamide riboside.
Claim 14
Dependent Claim
17 words
The method of claim 12, wherein the amount of said compound is from 0.2 to 1.0 μmole/min/kg.
Claim 15
Dependent Claim
14 words
The method of claim 9, wherein said tissue comprises part of a human organ.
Claim 16
Dependent Claim
15 words
The method of claim 14, wherein said organ is a kidney, heart, liver, or pancreas.
Claim 17
Dependent Claim
16 words
The method of claim 1, wherein said administering is to a human afflicted with Lesch-Nyhan Syndrome.
References Cited (Backward Citations)
US3332935A
Cited
US3803126A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-10 | 1989-09-09 | 1990-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-10 | 1993-09-09 | 1994-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-10 | 1997-09-09 | 1998-03-11 | $7700.00 | Window Closed / Lapsed |