US4571333A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled release naproxen and naproxen sodium tablets
Assignee: Syntex Pharmaceuticals International Ltd
•
Filing: 1983-06-14
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Granted: 1986-02-18
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Expires: 2003-06-14
Abstract
Abstract A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, said tablet being a homogeneous matrix comprising about 4-9 weight percent of hydroxypropylmethylcellulose having a number average molecular weight in the range of from about 80,000 to about 130,000, about 81-96 weight percent naproxen or naproxen sodium, 0.1 to about 2 weight percent of a pharmacetucailly acceptable lubricating agent, and 0 to about 8 weight percent of other pharmaceutically acceptable excipients.
Inventors
- 👤 Charles H. Hsiao
- 👤 John S. Kent
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 11:43
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2054; A61K31/00; A61K31/185; A61K31/19
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
64 words
A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, which tablet comprises a homogenous matrix comprising: about 4-6 weight percent of hydroxypropylmethylcellulose having a number average molecular weight in the range of from about 80,000 to about 130,000, about 81-96 weight percent of naproxen or naproxen sodium in an amount effective for once daily oral administration,
Claim 2
Dependent Claim
64 words
A controlled release tablet for once-daily oral administration of about 500-1200 mg of naproxen or naproxen sodium, which tablet comprises a homogenous matrix comprising: about 4-6 weight percent of hydroxypropylmethylcellulose having a number average molecular weight in the range of from about 80,000 to about 130,000, about 81-96 weight percent of naproxen or naproxen sodium in an amount effective for once daily oral administration,
Claim 3
Dependent Claim
24 words
1 to about 2 weight percent of a pharamaceutically acceptable lubricating agent, and 0 to about 8 weight percent of other pharmaceutically acceptable excipients.
Claim 4
Dependent Claim
24 words
1 to about 2 weight percent of a pharamaceutically acceptable lubricating agent, and 0 to about 8 weight percent of other pharmaceutically acceptable excipients.
Claim 5
Dependent Claim
10 words
The controlled release tablet of claim 1 which contains naproxen.
Claim 6
Dependent Claim
19 words
The controlled release tablet of claim 2 wherein the hydroxypropylmethylcellulose has a number average molecular weight of about 120,000-130,000.
Claim 7
Dependent Claim
41 words
The controlled release tablet of claim 3 which comprises: about 5 weight percent of the hydroxypropylmethylcellulose, about 92-95 weight percent naproxen, 0.1 to about 2 weight percent magnesium stearate, and 0 to about 1 weight percent of a pharmaceutically acceptable colorant.
Claim 8
Dependent Claim
15 words
The controlled release tablet of claim 4 wherein the amount of naproxen is 500 mg.
Claim 9
Dependent Claim
16 words
The controlled release tablet of claim 5 which contains about 0.01-0.05 weight percent FD&C Yellow #6.
Claim 10
Dependent Claim
15 words
The controlled release tablet of claim 4 wherein the amount of naproxen is 750 mg.
Claim 11
Dependent Claim
14 words
The controlled release tablet of claim 7 which contains 0.01-0.05 mg FD&C Yellow #6.
Claim 12
Dependent Claim
15 words
The controlled release tablet of claim 4 wherein the amount of naproxen is 1000 mg.
Claim 13
Dependent Claim
15 words
The controlled release tablet of claim 9 which contains about 0.01-0.05 mg. FD&C Yellow #6.
Claim 14
Dependent Claim
19 words
The controlled release tablet of claim 1 wherein the hydroxypropylmethylcellulose has a number average molecular weight of about 120,000-130,000.
Claim 15
Dependent Claim
43 words
The controlled release tablet of claim 11 which comprises: about 5 weight percent of the hydroxypropylmethylcellulose, about 85-95 weight percent naproxen or naproxen sodium, 0.1 to about 2 weight percent lubricating agent, and 0 to about 8 weight percent other pharmaceutically acceptable excipients.
Claim 16
Dependent Claim
19 words
The controlled release tablet of claim 12 wherein the amount of naproxen or naproxen sodium is about 500-550 mg.
Claim 17
Dependent Claim
19 words
The controlled release tablet of claim 12 wherein the amount of naproxen or naproxen sodium is about 750-800 mg.
Claim 18
Dependent Claim
18 words
The controlled release tablet of claim 12 wherein the amount of naproxen or naproxen sodium is 1000-1100 mg.
Claim 19
Dependent Claim
19 words
The controlled release tablet of claim 1 wherein the hydroxypropylmethylcellulose has a number average molecular weight of about 85,000-95,000.
Claim 20
Dependent Claim
19 words
The controlled release tablet of claim 16 wherein the amount of naproxen or naproxen sodium is about 500-550 mg.
Claim 21
Dependent Claim
19 words
The controlled release tablet of claim 16 wherein the amount of naproxen or naproxen sodium is about 750-800 mg.
Claim 22
Dependent Claim
19 words
The controlled release tablet of claim 16 wherein the amount of naproxen or naproxen sodium is about 1000-1100 mg.
Claim 23
Dependent Claim
11 words
The controlled release tablet of claim 1 which contains naproxen sodium.
Claim 24
Dependent Claim
61 words
The controlled release tablet of claim 20 which comprises: about 6 weight percent of hydroxypropylmethylcellulose having a number average molecular weight in the range of about 120,000-130,000, about 82-90 weight percent naproxen sodium, 0.1 to about 2 weight percent lubricating agent, about 4-6 weight percent of a pharmaceutically acceptable glident, and 0 to about 2 weight percent other pharmaceutically acceptable excipients.
Claim 25
Dependent Claim
17 words
The controlled release tablet of claim 21 wherein the amount of naproxen sodium is about 550 mg.
Claim 26
Dependent Claim
17 words
The controlled release table of claim 21 wherein the amount of naproxen sodium is about 1100 mg.
Claim 27
Dependent Claim
14 words
The controlled release tablet of claim 1 wherein the lubricating agent in magnesium stearate.
Claim 28
Dependent Claim
16 words
The controlled release tablet of claim 2 wherein the amount of naproxen is about 500 mg.
Claim 29
Dependent Claim
16 words
The controlled release tablet of claim 2 wherein the amount of naproxen is about 750 mg.
Claim 30
Dependent Claim
16 words
The controlled release tablet of claim 2 wherein the amount of naproxen is about 1000 mg.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-02-17 | 1989-08-19 | 1990-02-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-02-17 | 1993-08-19 | 1994-02-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-02-17 | 1997-08-19 | 1998-02-18 | $7700.00 | Window Closed / Lapsed |