Patent US4569844A successfully refreshed from Google Patents.
US4569844A
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Microencapsulation process, microcapsules and use thereof
Assignee: Mars Inc
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Filing: 1984-01-16
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Granted: 1986-02-11
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Expires: 2004-01-16
Abstract
Abstract What is disclosed is a process for the production of microcapsules by forming an emulsion of an aqueous solution of a compound having free amino groups in a liquid which is substantially non-polar or which has a polarity less than that of a 4:1 w/w mixture of cyclohexane and chloroform as the continuous phase, and adding a solution of a compound capable of polymerizing with the compound in the aqueous solution so that an interfacial polymerization reaction occurs.
Inventors
- 👤 David A. Jones
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 04:58
CPC Classifications
B; B01; B01J; B01J13/00; B01J13/02; B01J13/06; B01J13/14; B01J13/16; Y; Y10; Y10S; Y10S426/00; Y10S426/805; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
175 words
A method for making microcapsules containing an aqueous solution of a hydrophilic protein having a plurality of free amine groups, which method comprises forming an emulsion of said aqueous solution as the disperse phase in a liquid hydrocarbon which is a non-solvent for the protein and which is substantially non-polar or which has a polarity less than that of a 4:1 w/w mixture of cyclohexane and chloroform as the continuous phase, and adding to the resulting emulsion a solution of a compound selected from the group consisting of di- and poly-basic carboxylic acids, and anhydrides and chlorides of such acids, capable of reacting with amine groups to form a polymer, whereby an interfacial condensation polymerization reaction occurs between the protein and said compound to form microcapsules with a wall consisting substantially completely of cross-linked protein, the ratio of the continuous phase to said disperse phase being less than 12:1 to as little as 6:1 and said interfacial polymerization reaction occurring in at most 15 minutes at a temperature from room temperature up to 40° C.
Claim 2
Independent Claim
175 words
A method for making microcapsules containing an aqueous solution of a hydrophilic protein having a plurality of free amine groups, which method comprises forming an emulsion of said aqueous solution as the disperse phase in a liquid hydrocarbon which is a non-solvent for the protein and which is substantially non-polar or which has a polarity less than that of a 4:1 w/w mixture of cyclohexane and chloroform as the continuous phase, and adding to the resulting emulsion a solution of a compound selected from the group consisting of di- and poly-basic carboxylic acids, and anhydrides and chlorides of such acids, capable of reacting with amine groups to form a polymer, whereby an interfacial condensation polymerization reaction occurs between the protein and said compound to form microcapsules with a wall consisting substantially completely of cross-linked protein, the ratio of the continuous phase to said disperse phase being less than 12:1 to as little as 6:1 and said interfacial polymerization reaction occurring in at most 15 minutes at a temperature from room temperature up to 40° C.
Claim 3
Dependent Claim
17 words
A method as in claim 1 wherein the protein is a protein having a substantially linear structure.
Claim 4
Dependent Claim
27 words
A method as in claim 1 wherein the protein is a globular protein and has been modified to break-down, at least partially, the tertiary amine structure thereof.
Claim 5
Dependent Claim
14 words
A method as in claim 1 wherein the protein is a naturally occurring protein.
Claim 6
Dependent Claim
35 words
A method as claimed in claim 1 wherein the protein contains a relatively high proportion of amino acids containing two amine groups or contains at least some amino acids in the form of their amides.
Claim 7
Dependent Claim
25 words
A method as in claim 1 wherein the protein is present in the form of a component of a complex naturally occurring mixture of materials.
Claim 8
Dependent Claim
20 words
A method as in claim 6 wherein the mixture is whole egg, egg yolk, hemoglobin, or full cream condensed milk.
Claim 9
Dependent Claim
18 words
A method as in claim 1 wherein the aqueous solution contains another, different, polyamine admixed with said protein.
Claim 10
Dependent Claim
20 words
A method as in claim 1 wherein the aqueous protein solution has a concentration of at least 20% by weight.
Claim 11
Dependent Claim
21 words
A method as in claim 1 wherein said compound is sebacoyl chloride, adipoyl chloride, succinoyl chloride, terephthaloyl chloride, or succinic anhydride.
Claim 12
Dependent Claim
20 words
A method as in claim 1 wherein the liquid of the continuous phase is cyclohexane, n-decane, or 40/60 petroleum ether.
Claim 13
Dependent Claim
24 words
A method as in claim 1 wherein, after termination of the reaction, the capsules are separated from the continuous phase and dispersed in water.
Claim 14
Dependent Claim
20 words
A method as in claim 12 wherein a nondetergent surface active agent is present to assist the dispersion in water.
Claim 15
Dependent Claim
15 words
A method as in claim 13 wherein said surface active agent is a protective colloid.
Claim 16
Dependent Claim
15 words
A method as in claim 14 wherein said protective colloid is polyvinyl alcohol or gelatin.
Claim 17
Dependent Claim
19 words
A method as in claim 13 wherein said surface active agent is lecithin or an ester of a glyceride.
Claim 18
Dependent Claim
27 words
A method as in claim 12 wherein a solute is present in said water in sufficient amount to balance the osmotic pressure inside and outside the capsules.
Claim 19
Dependent Claim
10 words
Biodegradable edible microcapsules prepared by the method of claim 1.
Claim 20
Dependent Claim
21 words
A method for cultivating marine animal life which comprises feeding to said animal life biodegradable edible microcapsules as in claim 18.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1989-02-10 | 1989-08-12 | 1990-02-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-02-10 | 1993-08-12 | 1994-02-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-02-10 | 1997-08-12 | 1998-02-11 | $7700.00 | Window Closed / Lapsed |