Patent US4569801A successfully refreshed from Google Patents.
US4569801A
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Alkylsulfonamidophenylalkylamines
Assignee: Eli Lilly and Co
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Filing: 1984-10-15
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Granted: 1986-02-11
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Expires: 2004-10-15
Abstract
Abstract The present invention relates to a new class of alkylsulfonamidophenylalkylamines which are potent antiarrhythmic agents having good oral bioavailability properties.
Inventors
- 👤 Bryan B. Molloy
- 👤 Mitchell I. Steinberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:28
CPC Classifications
C; C07; C07C; C07C303/00; C07C303/36; C07C303/38; A; A61; A61K; A61K31/00; A61K31/16; A61K31/18; A61P; A61P9/00; A61P9/06; C07C311/00; C07C311/01; C07C311/02; C07C311/08
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
64 words
A compound of the formula ##STR3## wherein: R is C 1 -C 6 alkyl; R 1 is hydrogen, methyl or ethyl; R 2 is hydrogen or C 1 -C 3 alkyl; R 3 is hydrogen or C 1 -C 8 alkyl; R 4 is C 1 -C 10 alkyl; n is 2, 3, 4 or 5; and the pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
64 words
A compound of the formula ##STR3## wherein: R is C 1 -C 6 alkyl; R 1 is hydrogen, methyl or ethyl; R 2 is hydrogen or C 1 -C 3 alkyl; R 3 is hydrogen or C 1 -C 8 alkyl; R 4 is C 1 -C 10 alkyl; n is 2, 3, 4 or 5; and the pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
9 words
A compound of claim 1 wherein R is methyl.
Claim 4
Dependent Claim
14 words
A compound of claim 2 wherein R 3 is C 2 -C 4 alkyl.
Claim 5
Dependent Claim
14 words
A compound of claim 3 wherein R 4 is C 2 -C 10 alkyl.
Claim 6
Dependent Claim
14 words
A compound of claim 4 wherein both R 1 and R 2 are hydrogen.
Claim 7
Dependent Claim
15 words
The compound of claim 5 which is N-[4-[4-(ethylheptylamino)butyl]phenyl]methanesulfonamide, and its pharmaceutically acceptable acid addition salts.
Claim 8
Dependent Claim
9 words
The compound of claim 6 which is N-[4-[4-(ethylheptylamino)butyl]phenyl]methanesulfonamide ethanedioate.
Claim 9
Dependent Claim
9 words
The compound of claim 6 which is N-[4-[4-(ethylheptylamino)butyl]phenyl]methanesulfonamide monohydrobromide.
Claim 10
Dependent Claim
9 words
The compound of claim 6 which is N-[4-[4-(ethylheptylamino)butyl]phenyl]methanesulfonamide benzenesulfonate.
Claim 11
Dependent Claim
9 words
The compound of claim 6 which is N-[4-[4-(ethylheptylamino)butyl]phenyl]methanesulfonamide monohydrochloride.
Claim 12
Dependent Claim
15 words
The compound of claim 5 which is N-[4-[4-(butylheptylamino)butyl]phenyl]methanesulfonamide and it pharaceutically acceptable acid addition salts.
Claim 13
Dependent Claim
9 words
The compound of claim 11 which is N-[4-[4-(butylheptylamino)butyl]phenyl]methanesulfonamide ethanedioate.
Claim 14
Dependent Claim
20 words
A compound of claim 4 wherein one of R 1 and R 2 is hydrogen and the other is methyl.
Claim 15
Dependent Claim
15 words
The compound of claim 13 which is N-[4-[4-(ethylheptylamino)pentyl]phenyl]methanesulfonamide and its pharmaceutically acceptable acid addition salts.
Claim 16
Dependent Claim
9 words
The compound of claim 14 which is N-[4-[4-(ethylheptylamino)pentyl]phenyl]methanesulfonamide 2-hydroxy-1,2,3-propanetricarboxylate.
Claim 17
Dependent Claim
15 words
The compound of claim 13 which is N-[4-[4-(butylheptylamino)pentyl]phenyl]methanesulfonamide, and its pharmaceutically acceptable acid addition salts.
Claim 18
Dependent Claim
9 words
The compound of claim 16 which is N-[4-[4-(butylheptylamino)pentyl]phenyl]methanesulfonamide monohydrobromide.
Claim 19
Dependent Claim
23 words
A pharmaceutical formulation comprising an effective antiarrythmic amount of a compound of claim 1 and a pharmaceutically acceptable carrier, diluent or excipient therefor.
Claim 20
Dependent Claim
17 words
The formulation of claim 18 wherein the compound is N-[4-[4-(ethylheptylamino)butyl]phenyl]methanesulfonamide, and its pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-02-10 | 1989-08-12 | 1990-02-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-02-10 | 1993-08-12 | 1994-02-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-02-10 | 1997-08-12 | 1998-02-11 | $7700.00 | Window Closed / Lapsed |