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US4568694A
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Growth-enhancing cystamine derivatives
Assignee: May and Baker Ltd
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Filing: 1983-06-15
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Granted: 1986-02-04
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Expires: 2003-06-15
Abstract
Abstract Cystamine derivatives of the formula: <IMAGE> [wherein n represents 2 or 3, R1 and R2 each represents a hydrogen atom, or an alkyl group optionally substituted by a hydroxy, amino, alkylamino or dialkylamino group, or represents a cycloalkyl or aryl group, and X1 represents a group selected from the formulae =N-CN, =N-NO2, =N-COR3, =N-COOR3, =N-NH-CONH2, =N-SO2R3, =CH-NO2, =CH-SO2R3, =C(CN)2, =C(CN)COOR3 and =C(CN)CONH2 (wherein R3 represents an alkyl or aryl group), or R1 represents a hydrogen atom, R2 represents an alkyl group optionally substituted by a hydroxy, amino, alkylamino or dialkylamino group, or represents a cycloalkyl or aryl group and X1 represents an oxygen or sulphur atom] have been found to be useful in the promotion of the growth of non-human animals including birds. Prcesses for the preparation of the cystamine derivatives and compositions containing them for administration to non-human animals are described.
Inventors
- 👤 Richard M. Griffin
- 👤 Malcolm N. Palfreyman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 01:40
CPC Classifications
C; C07; C07C; C07C323/00; C07C323/23; C07C323/39; C07C323/43; C07C323/44
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
67 words
Cystamine derivatives of the formula: ##STR9## wherein n represents 2 or 3, R 1 and R 2 each represents a hydrogen atom, or an alkyl group optionally substituted by a hydroxy, amino, alkylamino or dialkylamino group, or represents a cycloalkyl or aryl group, and X 1 represents a group ═N--SO 2 R 3 , wherein R 3 represents an alkyl or aryl group, and their non-toxic salts.
Claim 2
Dependent Claim
67 words
Cystamine derivatives of the formula: ##STR9## wherein n represents 2 or 3, R 1 and R 2 each represents a hydrogen atom, or an alkyl group optionally substituted by a hydroxy, amino, alkylamino or dialkylamino group, or represents a cycloalkyl or aryl group, and X 1 represents a group ═N--SO 2 R 3 , wherein R 3 represents an alkyl or aryl group, and their non-toxic salts.
Claim 3
Dependent Claim
11 words
Cystamine derivatives according to claim 1 wherein R 3 represents methyl.
Claim 4
Dependent Claim
13 words
Cystamine derivatives according to claim 1 wherein R 1 represents a hydrogen atom.
Claim 5
Dependent Claim
13 words
Cystamine derivatives according to claim 1 wherein R 2 represents a dialkylaminoalkyl group.
Claim 6
Dependent Claim
13 words
Cystamine derivatives according to claim 4 wherein R 2 represents a dimethylaminoethyl group.
Claim 7
Dependent Claim
13 words
Cystamine derivatives according to claim 1 wherein R 2 represents an alkyl group.
Claim 8
Dependent Claim
11 words
Cystamine derivatives according to claim 6 wherein R 2 represents methyl.
Claim 9
Dependent Claim
20 words
Cystamine derivatives according to claim 1 wherein the symbol n in the general formula depicted in claim 1 represents 2.
Claim 10
Dependent Claim
33 words
Cystamine derivatives according to claim 1 wherein the two halves --S(CH 2 ) n NHC(═X 1 )NR 1 R 2 of the compound of the general formula depicted in claim 1 are identical.
Claim 11
Dependent Claim
65 words
Cystamine derivatives according to claim 1 in which alkyl groups or moieties within the definitions of R 1 , R 2 and R 3 contain from 1 to 6 carbon atoms, cycloalkyl groups within the definitions of R 1 and R 2 contain from 3 to 8 carbon atoms, and an aryl group represented by R 1 , R 2 or R 3 is phenyl.
Claim 12
Dependent Claim
14 words
A cystamine derivative according to claim 1 which is N,N'-bis(N"-methyl-N"'-methylsulphonylamidino)cystamine, and non-toxic salts thereof.
Claim 13
Dependent Claim
57 words
A method of improving the growth rate and/or the feed conversion ratio of non-human animals which comprises administering to such an animal at least one cystamine derivative of the general formula specified in claim 1, or a non-toxic salt thereof, in an amount sufficient to improve the growth rate and/or the feed conversion ratio of the animal.
Claim 14
Dependent Claim
17 words
A method according to claim 12 wherein the cystamine compound is administered to pigs, cattle or poultry.
Claim 15
Dependent Claim
18 words
A method according to claim 13 in which the cystamine compound is administered to calves, chickens or turkeys.
Claim 16
Dependent Claim
55 words
Compositions suitable for administration to non-human animals to improve the growth rate and/or the feed conversion ratio, which comprise an effective growth rate and/or feed conversion ratio improving amount of at least one cystamine derivative of the general formula specified in claim 1, or a non-toxic salt thereof, in association with a physiologically innocuous carrier.
Claim 17
Dependent Claim
73 words
Compositions suitable for addition to animal feedstuffs, to incorporate therein an effective growth rate and/or feed conversion ratio improving amount of a cystamine derivative of the general formula specified in claim 1, or a non-toxic salt thereof, which compositions comprise a cystamine derivative of the general formula specified in claim 1, or a non-toxic salt thereof, in association with a wetting, suspending, dispersing or emulsifying agent, with or without a physiologically innocuous carrier.
Claim 18
Dependent Claim
84 words
Concentrates for addition to drinking water for non-human animals to incorporate therein an effective growth rate and/or feed conversion ratio improving amount of a cystamine derivative of the general formula specified in claim 1, or a non-toxic salt thereof, which compositions comprise a cystamine derivative of the general formula specified in claim 1, or a non-toxic salt thereof, in association with a wetting, suspending, dispersing or emulsifying agent, with or without a physiologically innocuous carrier, or in association with a water-soluble physiologically innocuous carrier.
Claim 19
Dependent Claim
22 words
Compositions according to claim 15 which are solid or semi-solid and the carrier is provided at least in part by a feedstuff.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-02-03 | 1989-08-05 | 1990-02-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-02-03 | 1993-08-05 | 1994-02-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-02-03 | 1997-08-05 | 1998-02-04 | $7700.00 | Window Closed / Lapsed |